Erratum to: “In vitro biological activity comparison of some hydroxyapatite-based composite materials using simulated body fluid”

Czikó, Melinda; Bogya, Erzsébet-Sára; Barabáş, Réka; Bizo, Liliana; Ştefan, R.

doi:10.2478/s11532-013-0316-2

Cited by 1 publication

(1 citation statement)

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“…Chitosan (CHI) is a natural polymer. It has been widely used for hemostatic applications due to its excellent biocompatibility and biodegradable properties, along with its antimicrobial and hemostatic activities . However, pure CHI is typically modified for applications because pure CHI has poor water solubility.…”

Section: Introductionmentioning

confidence: 99%

Hemostasis mechanism and applications of N-alkylated chitosan sponge

Huang

Feng

Zhang

et al. 2017

Polym. Adv. Technol.

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Chitosan (CHI) is a versatile biological material that is well known for its hemostatic properties. This preliminary study evaluated several self-assembling hydrophobically modified chitosan (HM-CHI) sponges to determine their efficacy on hemostasis. Fourier transform infrared (FT-IR) spectroscopy was used to determine the successful graft of dodecyl groups onto the nitrogen atoms of CHI molecules. A platelet aggregation assay revealed that HM-CHI accelerated the platelet aggregation rate. Fluorescence spectroscopy showed that the HM-CHI changed the structure of fibrinogen in blood. Activated partial thromboplastin time, prothrombin time, fibrinogen time, and thromboelastographic assays were used to explore the effect of HM-CHI on the autologous blood coagulation pathway. Finally, a hemostatic sponge was made with HM-CHI and freeze-dried zeolite composite film and was applied to the rat femoral artery hemostasis model. A hemostasis time of 86 AE 5 sec was achieved, which was significantly better than the one composed with pure CHI. The experimental results of the HM-CHI hemostatic materials are inspiring and will encourage the research and development of such materials. HM-CHI may be a strong candidate as a safe and effective hemostatic material.

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Section: Introductionmentioning

confidence: 99%