Erratum to: NT-020 treatment reduces inflammation and augments Nrf-2 and Wnt signaling in aged rats

Flowers, Antwoine; Lee, Jea-Young; Grimmig, Bethany; Acosta, Sandra; Small, Brent J.; Sanberg, Cyndy D.; Bickford, Paula C.

doi:10.1186/s12974-016-0669-5

Cited by 3 publications

(5 citation statements)

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“…Decreased expression of nuclear factor erythroid 2-related factor 2 (Nrf2) has also been observed with aging. Nrf2 is a transcription factor that regulates the expression of antioxidant proteins and, if it is downregulated with age, this is consistent with the known age-related increase in oxidative stress (Huang et al 2019;Fulop et al 2018;Flowers et al 2016).…”

Section: Introductionsupporting

confidence: 73%

“…In spite of some of the methodological challenges involved with working with serum, these findings contribute to the existing body of knowledge on how nutraceuticals impact the aging milieu and exert therapeutic effects. In particular, we have found that NT-020 reverses the negative effects of age on stem cell proliferation, enhances neurogenesis, and leads to improved performance on cognitive behavioral paradigms (Acosta et al 2010;Bachstetter et al 2010;Bickford et al 2015;Flowers et al 2015;Flowers et al 2016;Kaneko et al 2012;Shytle et al 2010;Small et al 2014;Yasuhara et al 2008). These data provide insight into the mechanisms of action underpinning NT-020-mediated therapeutic effects.…”

Section: Discussionmentioning

confidence: 74%

“…While there is an increase in proinflammatory and other pro-aging factors and a decrease in anti-inflammatory factors with age, a complete profile of the aging milieu has yet to be identified, although parabiosis studies have contributed significantly to this effort (Villeda et al 2011;Villeda et al 2014;Smith et al 2015). The current study sought to identify factors that were significantly changed with age and could be ameliorated by treatment with the polyphenol-rich dietary supplement NT-020, as NT-020 has been demonstrated to have beneficial effects in vitro and in vivo (Yasuhara et al 2008;Shytle et al 2010;Bachstetter et al 2010;Kaneko et al 2012;Small et al 2014;Bickford et al 2015;Flowers et al 2016).Eleven proteins were found to change significantly when comparing old control rats with young controls. Of these, ceruloplasmin, insulin-like growth factor binding protein acid labile subunit (IGFALS), and maltase-glucoamylase (Mgam) were the most noteworthy.…”

Section: Discussionmentioning

confidence: 98%

“…As the population ages, there is increased susceptibility to the onset of disease and age-related degenerative conditions, making aging a central area of interest in medical sciences research (Wagster et al 2012;Flowers et al 2016). Aging is a complex and multifactorial physiological process associated with decreased stem cell proliferation in stem cell niches throughout the body, leading to reduced tissue rejuvenation and loss of organ function (Murshid et al 2013;Bickford et al 2015).…”

Section: Introductionmentioning

confidence: 99%

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Effects of nutraceutical intervention on serum proteins in aged rats

et al. 2020

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Aging is associated with many pathophysiological changes that could lead to the onset of degenerative disease. Some of the physiological changes that occur with aging include increased inflammation and decreased stem cell proliferation, leading to decreased capacity for tissue regeneration and loss of function. In previous studies, we and others have found nutraceutical intervention to ameliorate some of the deleterious effects associated with aging. In particular, we have previously shown that NT-020, a supplement composed of a proprietary blend of blueberries, green tea, vitamin D3, and carnosine, is able to rescue age-related cognitive deficits, impaired neurogenesis, and inflammation in rats. We have also previously demonstrated that stem cells cultured with old serum showed decreased proliferation; however, when stem cells were cultured in serum from old rats given a diet supplemented with NT-020, proliferation did not differ from that of cells cultured with serum from young rats. While it is clear that NT-020 is exerting a therapeutic, anti-aging effect, the mechanisms of action were yet to be fully elucidated.To that end, in the present study, we conducted a bioinformatics experiment to examine the rat proteome of serum from young and old control rats and young and old rats given a diet supplemented with NT-020. Serum from old rats showed an increase in some inflammatory and pro-aging factors while serum from old rats given a diet supplemented with NT-020 showed an increase in some anti-aging factors, most notably proteins associated with the complement system and autophagy. A number of immune functions that increase with age were shown to be downregulated with NT-020 treatment.

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Section: Introductionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Effects of nutraceutical intervention on serum proteins in aged rats

et al. 2020

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“…Research conducted by Popa-Wagner et al ( 2007b ) demonstrated that augmented early inflammatory response may interfere with recovery mechanisms. Stroke models demonstrated more severe neuroinflammation in aged rats (Buga et al, 2013 ), while oxidative stress induced higher levels of proinflammatory cytokines and chemokines in aged compared with young adult rats (Flowers et al, 2016 ). Consistently, lipopolysaccharide (LPS) was demonstrated to induce prolonged neuroinflammation and elevated levels of proinflammatory cytokines in aged compared with young adult rats (Fu et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Differentially Severe Cognitive Effects of Compromised Cerebral Blood Flow in Aged Mice: Association with Myelin Degradation and Microglia Activation

Wolf

Lotan

Lifschytz

et al. 2017

Front. Aging Neurosci.

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Bilateral common carotid artery stenosis (BCAS) models the effects of compromised cerebral blood flow on brain structure and function in mice. We compared the effects of BCAS in aged (21 month) and young adult (3 month) female mice, anticipating a differentially more severe effect in the older mice. Four weeks after surgery there was a significant age by time by treatment interaction on the radial-arm water maze (RAWM; p = 0.014): on the first day of the test, latencies of old mice were longer compared to the latencies of young adult mice, independent of BCAS. However, on the second day of the test, latencies of old BCAS mice were significantly longer than old control mice (p = 0.049), while latencies of old controls were similar to those of the young adult mice, indicating more severe impairment of hippocampal dependent learning and working memory by BCAS in the older mice. Fluorescence staining of myelin basic protein (MBP) showed that old age and BCAS both induced a significant decrease in fluorescence intensity. Evaluation of the number oligodendrocyte precursor cells demonstrated augmented myelin replacement in old BCAS mice (p < 0.05) compared with young adult BCAS and old control mice. While microglia morphology was assessed as normal in young adult control and young adult BCAS mice, microglia of old BCAS mice exhibited striking activation in the area of degraded myelin compared to young adult BCAS (p < 0.01) and old control mice (p < 0.05). These findings show a differentially more severe effect of cerebral hypoperfusion on cognitive function, myelin integrity and inflammatory processes in aged mice. Hypoperfusion may exacerbate degradation initiated by aging, which may induce more severe neuronal and cognitive phenotypes.

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