Erratum to: Prolonged thrombocytopenia after living donor liver transplantation is a strong prognostic predictor irrespective of splenectomy: the significance of ADAMTS13 and graft function

Abstract

production due to hepatocyte dysfunction, irrespective of splenectomy." Errors have subsequently been identified in the original publication, and the following corrections should be noted: 1. The revised Figs. 1 and 5 and Tables 1, 2, 3 and 4 were replaced with this erratum. 2. References [18] and [27] should be replaced as below. 18. Takei Y, Marzi I, Gao WS, Gores GJ, Lemasters JJ, Thurman RG. Leukocyte adhesion and cell death following orthotopic liver transplantation in the rat. Transplantation. 1991;51(5):959-65. 27. Cywes R, Mullen JB, Stratis MA, Greig PD, Levy GA, Harvey PR, Strasberg SM. Prediction of the outcome of transplantation in man by platelet adherence in donor liver allografts. Evidence of the importance of prepreservation injury. Transplantation. 1993;56(2):316-23. Erratum to: Int J Hematol (2014) 99:418-428 The author would like to correct the errors in the publication of the original article. The corrected details are given below for your reading. The original article was published with the incorrect title. The correct title should read: "Prolonged thrombocy-topenia after living donor liver transplantation is a strong prognostic predictor irrespective of splenectomy: the significance of ADAMTS13 and graft function". Secondly, the last two sentences beneath the heading "Abstract" should read as "Irrespective of splenectomy, platelet counts and ADAMTS13 activity in the LP group remained low until POD28, while VWF/ADAMTS13 ratio significantly increased until POD28. These results suggest that prolonged thrombocytopenia after LDLT was associated with not only a decrease in ADAMTS13 due to sinusoidal endothelial cell injury, but also low TPO The online version of the original article can be found under

Platelets Activation and Liver Transplantation

“…Marubashi et al [31] found that seven patients who underwent simultaneous splenectomy showed a remarkable increase in their platelet counts after LDLT on POD14, with the peak in the platelet count seen at POD28. We encountered several LDLT patients who had suffered from prolonged thrombocytopenia even after splenectomy [27]. Our study also showed that the platelet counts after splenectomy in operations other than LDLT significantly increased on POD7 and peaked on POD14.…”

“…Although the patients in our study gradually recovered from early thrombocytopenia after LDLT within 14 days, there were several patients who showed a delayed recovery of their platelet count, exhibiting prolonged thrombocytopenia [27]. Adult LDLT patients were divided into 2 groups based on their platelet counts (100 × 10 3 / μL) on POD14: high-and low-platelet (HP and LP, respectively) groups.…”

“…This suggested that the constant production of TPO in the hepatocytes was preserved in the LP group on POD14, while on POD28 its production was significantly impaired, suggesting graft dysfunction. Although the reasons why the preoperative TPO levels were significantly higher in the LP group than in the HP group remained unclear, the low preoperative platelet counts in the LP group may be associated with the high TPO levels [27].…”

“…Adult LDLT patients were divided into 2 groups based on their platelet counts (100 × 10 3 / μL) on POD14: high-and low-platelet (HP and LP, respectively) groups. The 6-month survival rate in the LP group was significantly lower than that in the HP group (61.1% vs. 93.5%) [27], suggesting that a platelet count of <100 × 10 3 / μl on POD14 is a strong predictor of the patient survival after LDLT ( Figure 1). …”

“…The sGPVI levels were positively correlated with the platelet counts before LDLT and negatively correlated with those on POD3, suggesting that the activation of platelets might be the highest on POD3. The ADAMTS13 levels in the patients with LDLT were the lowest on POD1, but the peaks differed between survivors and nonsurvivors [13,27,55]. The VWFpp levels were markedly elevated on POD7, but the peaks also differed between survivors and nonsurvivors [13,27,55].…”