Erratum to “Simultaneous type 1 diabetes onset in mother and son coincident with an enteroviral infection” [J. Clin. Virol. 33 (2) (2005) 158–167]

Hindersson, Maria; Elshebani, Asma; A, Orn; Tuvemo, Torsten; Frisk, Gun

doi:10.1016/j.jcv.2005.06.003

Cited by 8 publications

(11 citation statements)

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“…The nondenatured epitopes confer a narrow EV detection range to QPIA, which can be a drawback for EV diagnosis, and requires a mixture of 12 antigens to cover IgM from as many EV infections as possible. It is therefore reassuring that T1D-EV-QPIA with a binary EV mixture containing EV isolates from family infections [Hindersson et al, 2005;Elshebani et al, 2006], where several family members got diabetes, clearly differentiated controls from T1D patients. The IgM values correlated with the presence of EV RNA as detected by EV PCR.…”

Section: Methodological Aspectsmentioning

confidence: 92%

“…The virus isolated from the T1D boy Adrian, was used as one of the two antigens in the T1D-EV-QPIA. The other isolate is described in Hindersson et al [2005]. Samples from patients and controls were handled equally, and were stored together.…”

Section: Subjectsmentioning

confidence: 99%

“…Both isolates were obtained at T1D onset. They were serotyped and/or genotyped to CVB5 and Echovirus 21, respectively, as described earlier [Hindersson et al, 2005;Elshebani et al, 2006]. Both isolates were passaged in GMK cells three times.…”

Section: Viral Antigen For T1d-ev-qpiamentioning

confidence: 99%

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Recent enterovirus infection in type 1 diabetes: Evidence with a novel IgM method

Elfaitouri¹,

Berg

Frisk

et al. 2007

Journal of Medical Virology

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Enterovirus (EV) infection has been associated with Type 1 (T1D) diabetes and on a few occasions virus could be isolated at onset of the disease. Using two such isolates as antigens in a quantitative PCR enhanced immunoassay (T1D-EV-QPIA) we have measured IgM antibodies against such potentially diabetogenic viruses in serum from 33 newly diagnosed T1D children, 24 siblings, and 27 healthy children. Sera were also analysed with regard to autoantibodies against GAD65, the cytokine TNF-alpha and the chemokine IP-10. EV-RNA detection was performed on peripheral blood mononuclear cells (PBMC). IgM antibodies against this "new" EV antigen were more frequent in serum from T1D children than in serum from siblings and/or controls (P < 0.001). EV-RNA was detected more frequently in PBMC from T1D children than in healthy control children (P < 0.001) and also compared to the siblings (P < 0.003). The cytokine TNF-alpha was less frequently detected in serum from the T1D children compared with serum from siblings and/controls (P < 0.001). A positive correlation was found between the results obtained with the T1D-EV-QPIA and the EV-PCR (P < 0.001). These findings are in line with earlier findings of an increased frequency of enteroviral infections in newly diagnosed T1D patients. In addition, we found that T1D children at onset of the disease had lower frequencies of the chemokine TNF-alpha in their serum than age- and sex-matched controls had, suggesting an impaired immune response.

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Section: Methodological Aspectsmentioning

confidence: 92%

Section: Subjectsmentioning

confidence: 99%

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Recent enterovirus infection in type 1 diabetes: Evidence with a novel IgM method

Elfaitouri¹,

Berg

Frisk

et al. 2007

Journal of Medical Virology

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“…On the other hand, the immunization conferred by the usual childhood vaccinations does not seem to be associated with autoimmune stigmata favouring T1D [12]. The role of several viruses such as rotaviruses, adenoviruses, retroviruses, reoviruses, cytomegalovirus, Epstein-Barr virus, mumps virus, or rubella virus, was invoked [13][14][15]. Enteroviruses seem, however, to be among the viruses most able to trigger pancreatic damages leading to diabetes.…”

Section: Introductionmentioning

confidence: 99%

“…Prospective studies also showed that enterovirus infections were significantly more frequent in children who become positive for autoantibodies (pre-diabetic children) than in controls, and that these infections were clustered in the period immediately preceding the appearance of these autoantibodies [23][24][25][26][27]. If other studies carried out on different populations obtained clashing results [12,28], the existence of cases of simultaneous onset of T1D in members of the same family, following an enterovirus infection, is another argument in favour of the role of these viruses, namely CV-B, in the pathogenesis of this autoimmune disease [14]. This epidemiological association is supported by clinical observations, namely the isolation of CV-B4 from the pancreas of diabetic subjects [29,30].…”

Section: Introductionmentioning

confidence: 99%

Coxsackievirus B4 and type 1 diabetes pathogenesis: contribution of animal models

Jaïdane

Sané²,

Gharbi

et al. 2009

Diabetes Metabolism Res

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The role of enteroviruses, in particular type B coxsackieviruses (CV-B), in type 1 diabetes (T1D) pathogenesis is supported by epidemiological, clinical and experimental observations.The investigation of T1D pathogenesis benefits from the contribution of animal models called spontaneously diabetic. Among these animals the non-obese diabetic (NOD) mouse and the bio-breeding diabetes-prone (BBDP) rat present a genetic susceptibility manifested by the expression of an autoimmune diabetes similar to the pathology observed in human beings. Other models whose genetic predisposition is less known are of considerable contribution as well. Numerous major observations relative to several aspects of T1D pathogenesis in the context of CV-B infections, such as susceptibility, diabetogenicity, pancreatotropism, mechanisms of beta cells destruction and others, have been deduced thanks to investigations with animal models. Despite their limits, these models are necessary in improving our knowledge of the role of enteroviruses, like CV-B4, in the pathogenesis of T1D, and the recent advances ensuing from their contribution may have important therapeutic and preventive spin-offs.

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Enterovirus markers and serum CXCL10 in children with type 1 diabetes

Berg

Tuvemo

Frisk

2010

Journal of Medical Virology

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Most patients with type 1 diabetes are considered to have a T-cell mediated autoimmune disease. The chemokine CXCL10 promotes the migration of activated T-cells. Virus infections might contribute to the pathogenesis of type 1 diabetes and enterovirus protein and/or genome have been detected in b-cells from a majority of tested newly diagnosed children with type 1 diabetes. The chemokine CXCL10 is induced in human islet cells by enterovirus infections in vivo and in vitro, but is not expressed in islets from normal organ donors. Since CXCL10 is a chemokine known to be induced by virus infections and/or cellular damage, our aim was to study if levels of CXCL10 are elevated in serum from children with type 1 diabetes and whether it correlates to the presence of enterovirus markers. CXCL10, neutralizing antibody titer rises against certain enterovirus, and antibodies against GAD65 were measured in serum, and enterovirus PCR was performed on whole blood from 83 type 1 diabetes patients at onset, 48 siblings and 69 controls. CXCL10 was also measured in serum from 46 patients with proven enterovirus infection and in serum from 46 patients with other proven virus infections. The CXCL10 serum levels were not elevated in children at onset of type 1 diabetes and there was a considerable overlap between the groups with 99 (8-498) pg/ml in serum from children with type 1 diabetes, 120 (17-538) pg/ml in serum from controls, and 117 (7-448) pg/ml in siblings of the children with type 1 diabetes. The CXCL10 serum levels in patients with proven enterovirus infection were slightly increased compared to the levels in the other groups, 172 (0-585) pg/ml but there was no statistically significant difference. In contrast, CXCL10 serum levels in patients with other proven virus infections were clearly elevated 418 (34-611) pg/ml. Despite that elevated CXCL10 levels have been demonstrated in some groups of patients with type 1 diabetes, in this study the mean CXCL10 serum levels were not elevated in patients with type 1 diabetes neither in patients with proven enterovirus infection. In contrast, in patients with other virus infections the CXCL10 levels were elevated, presumably reflecting the severity or the site of infection. This suggests that local production of CXCL10 in the affected organ cannot be measured reproducible in serum and that its potential use in clinical practice is limited.

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Erratum to “Simultaneous type 1 diabetes onset in mother and son coincident with an enteroviral infection” [J. Clin. Virol. 33 (2) (2005) 158–167]

Cited by 8 publications

References 0 publications

Recent enterovirus infection in type 1 diabetes: Evidence with a novel IgM method

Recent enterovirus infection in type 1 diabetes: Evidence with a novel IgM method

Coxsackievirus B4 and type 1 diabetes pathogenesis: contribution of animal models

Enterovirus markers and serum CXCL10 in children with type 1 diabetes

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