Error processing-associated event-related potentials in schizophrenia and unaffected siblings

Simmonite, Molly; Bates, Alan; Groom, Madeleine J.; Jackson, Georgina M.; Hollis, Chris; Liddle, Peter F.

doi:10.1016/j.ijpsycho.2012.01.012

Cited by 42 publications

(43 citation statements)

References 44 publications

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“…If, as we and others have proposed, deficient error processing mediates the pathway between genetic predisposition and illness by interfering with adaptive responses to outcomes (e.g., Olvet and Hajcak, 2008), early intervention and prevention may be possible, for example, in individuals at high risk for schizophrenia who show a blunted ERN (e.g., Laurens et al, 2010;Perez et al, 2012;Simmonite et al, 2012). It may also be possible to intervene to prevent relapse.…”

Section: Establishing the Clinical Relevance Of Error Processing Defimentioning

confidence: 88%

“…Even in the context of an abnormal ERN, however, the Pe is intact in patients in many (Alain et al, 2002;Mathalon et al, 2002;Morris et al, 2006;Simmonite et al, 2012) but not all studies (Foti et al, 2012;Perez et al, 2012). Immediate errorrelated performance adjustments such as post-error slowing and error self-correction are also often intact Rist, 1994, 1999;Levy et al, 1998;Mathalon et al, 2002;Laurens et al, 2003;Polli et al, 2006Polli et al, , 2008, although impaired performance adjustments have also been reported (Malenka et al, 1982(Malenka et al, , 1986Carter et al, 2001;Turken et al, 2003).…”

Section: Schizophreniamentioning

confidence: 99%

“…Functional and structural ACC abnormalities, which predict the onset of psychosis (Fornito et al, 2008), are seen in never-medicated high-risk youth (Whalley et al, 2006), and in never-medicated children experiencing psychotic symptoms (Jacobson et al, 2010). In addition, a blunted ERN, similar to that observed in schizophrenia, is seen in syndromally-unaffected siblings (Simmonite et al, 2012), in never-medicated children with putative antecedents to schizophrenia (Laurens et al, 2010) and in antipsychotic naïve patients at high clinical risk for psychosis . These studies suggest that antipsychotic drugs do not fully account for blunted error processing or functional and structural ACC abnormalities in schizophrenia.…”

Section: Schizophreniamentioning

confidence: 99%

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Neural Markers of Errors as Endophenotypes in Neuropsychiatric Disorders

Manoach¹,

Agam²

2016

Innovations in Cognitive Neuroscience

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Learning from errors is fundamental to adaptive human behavior. It requires detecting errors, evaluating what went wrong, and adjusting behavior accordingly. These dynamic adjustments are at the heart of behavioral flexibility and accumulating evidence suggests that deficient error processing contributes to maladaptively rigid and repetitive behavior in a range of neuropsychiatric disorders. Neuroimaging and electrophysiological studies reveal highly reliable neural markers of error processing. In this review, we evaluate the evidence that abnormalities in these neural markers can serve as sensitive endophenotypes of neuropsychiatric disorders. We describe the behavioral and neural hallmarks of error processing, their mediation by common genetic polymorphisms, and impairments in schizophrenia, obsessive-compulsive disorder, and autism spectrum disorders. We conclude that neural markers of errors meet several important criteria as endophenotypes including heritability, established neuroanatomical and neurochemical substrates, association with neuropsychiatric disorders, presence in syndromallyunaffected family members, and evidence of genetic mediation. Understanding the mechanisms of error processing deficits in neuropsychiatric disorders may provide novel neural and behavioral targets for treatment and sensitive surrogate markers of treatment response. Treating error processing deficits may improve functional outcome since error signals provide crucial information for flexible adaptation to changing environments. Given the dearth of effective interventions for cognitive deficits in neuropsychiatric disorders, this represents a potentially promising approach.

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Section: Establishing the Clinical Relevance Of Error Processing Defimentioning

confidence: 88%

Section: Schizophreniamentioning

confidence: 99%

Section: Schizophreniamentioning

confidence: 99%

See 1 more Smart Citation

Neural Markers of Errors as Endophenotypes in Neuropsychiatric Disorders

Manoach¹,

Agam²

2016

Innovations in Cognitive Neuroscience

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“…The ERN is a deflection in the event-related potential that appears when a person commits an error in a choice task. The ERN is reduced in schizophrenic patients but is partially normalized by medication (Bates et al, 2004;Simmonite et al, 2012). It is likely generated in the anterior cingulate cortex by processes triggered by decreased firing of dopaminergic cells in the ventral tegmental area (Holroyd and Coles, 2002;Jocham and Ullsperger, 2009).…”

Section: Parallels To Other Conditions Involving Cortical Dysfunctionmentioning

confidence: 99%

Mechanisms underlying cortical resonant states: implications for levodopa-induced dyskinesia

Richter

Halje

Petersson

2013

Reviews in the Neurosciences

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A common observation in recordings of neuronal activity from the cerebral cortex is that populations of neurons show patterns of synchronized oscillatory activity. However, it has been suggested that neuronal synchronization can, in certain pathological conditions, become excessive and possibly have a pathogenic role. In particular, aberrant oscillatory activation patterns have been implicated in conditions involving cortical dysfunction. We here review the mechanisms thought to be involved in the generation of cortical oscillations and discuss their relevance in relation to a recent finding indicating that high-frequency oscillations in the cerebral cortex have an important role in the generation of levodopa-induced dyskinesia. On the basis of these insights, it is suggested that the identification of physiological changes associated with symptoms of disease is a particularly important first step toward a more rapid development of novel treatment strategies.

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“…Whereas some studies have found Pe and Pc amplitudes to be normal in schizophrenia (e.g., Alain et al, 2002;Mathalon et al, 2002;Morris et al, 2006), others have found blunted Pe and Pc amplitudes (Perez et al, 2011;Foti et al, 2012). Reduced ERN amplitude has also been reported in individuals with high clinical (Laurens et al, 2010;Perez et al, 2011) and genetic (Simmonite et al, 2012) risk for schizophrenia, indicating a possible trait marker for vulnerability to psychosis. Post-error reaction time slowing has been found in some studies (Alain et al, 2002;Kerns et al, 2005), but not all (Bates et al, 2002;Mathalon et al, 2002;Morris et al, 2006).…”

Section: Introductionmentioning

confidence: 98%