Error-related brain activity and internalizing disorder symptom dimensions in depression and anxiety

Gorka, Stephanie M.; Burkhouse, Katie L.; Afshar, Kaveh; Phan, K. Luan

doi:10.1002/da.22648

Cited by 23 publications

(18 citation statements)

References 78 publications

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“…To capture more specific symptoms, participants also completed the Inventory for Depression and Anxiety Symptoms-II (IDAS-II; Watson et al, 2012), which includes distinct, factor analytically derived symptom scales that map onto DSM-IV anxiety disorders. Within the current sample, we have previously demonstrated that baseline ERN amplitude is specifically associated with fear-based anxiety symptoms, and not broad anxiety/general distress (Gorka et al, 2017). In our prior paper, fear-based anxiety symptoms were captured using the IDAS-II by Z-scoring and averaging the panic, social anxiety, claustrophobia, traumatic intrusions and avoidance subscales.…”

Section: Assessment Of Psychopathologymentioning

confidence: 79%

“…Beyond discrete diagnostic categories, individuals with high trait anxiety (Olvet and Hajcak, 2009), high negative affect (Hajcak et al, 2004), and increased behavioral inhibition (Boksem et al, 2006) are also characterized by an increased ERN. Contributing to this literature, we recently found that greater ERN amplitude was associated with greater levels of fear-based anxiety symptoms (eg, panic, social anxiety), but was unrelated to distress/ misery symptoms (eg, depression), in a heterogeneous comorbid patient population (Gorka et al, 2017) and concluded that the ERN may be an objective, psychophysiological marker that tracks the severity of anxiety psychopathology. Of note, however, is that the functional significance of the ERN is still a topic of debate and there are several existing theories that shed light on the mechanisms that may contribute to an enhanced ERN in anxious populations.…”

Section: Introductionmentioning

confidence: 91%

“…These scales were chosen, in particular, as they reflect the symptoms of the 'fear disorders' (ie, PD, SAD, phobia, and PTSD), identified in numerous large-scale, factor analytic studies (Slade and Watson, 2006). Given the findings from Gorka et al (2017), and the potentially unique relation between the ERN and fear-based anxiety, we calculated an identical IDAS-II fear dimension in the current study (T1 α for IDAS fear dimension = 0.90).…”

Section: Assessment Of Psychopathologymentioning

confidence: 99%

“…Detailed descriptions of our EEG recording and processing procedures have been published elsewhere (eg, Gorka et al, 2017;Gorka et al, 2016). In brief, EEG was recorded during the task using the ActiveTwo BioSemi system (BioSemi, Amsterdam, the Netherlands).…”

Section: Electroencephalogram Data Collection and Processingmentioning

confidence: 99%

“…Data were re-referenced to the average of the two mastoids and high-pass (0.1 Hz) and low-pass (30 Hz) filtered. Data were segmented beginning 500 ms before each response onset and continuing for 1500 ms. Standard artifact rejection procedures were used (see Gorka et al, 2017;Gorka et al, 2016). Baseline correction for each trial was performed using the 500 to 300 ms prior to response onset.…”

Section: Electroencephalogram Data Collection and Processingmentioning

confidence: 99%

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Error-related Brain Activity as a Treatment Moderator and Index of Symptom Change during Cognitive-Behavioral Therapy or Selective Serotonin Reuptake Inhibitors

Gorka

Burkhouse

Klumpp

et al. 2017

Neuropsychopharmacol.

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Increased neural error monitoring, as measured by the error-related negativity (ERN), is a transdiagnostic neurobiological marker of anxiety. To date, little is known about whether the ERN can inform the choice between first-line anxiety disorder treatments and whether the ERN changes following treatment completion. The aim of the study was to therefore assess whether the ERN is a treatment moderator and index of symptom change during cognitive-behavioral therapy (CBT) or selective serotonin reuptake inhibitors (SSRIs). Participants included adult volunteers (M age=25.8±8.5; 67% female) with principal anxiety disorders (n=60) or no lifetime history of Axis I psychopathology (ie, healthy controls; n=26). A flanker task was used to elicit the ERN at baseline and 12 weeks later, following either CBT or SSRIs in the patient sample. Results indicated that baseline ERN was a significant treatment moderator such that a more enhanced baseline ERN was associated with greater reduction in anxiety symptoms within individuals who received CBT but not SSRIs. Results also revealed that the ERN increased pre- to post-treatment among patients randomized to SSRIs, but remained stable among patients randomized to CBT and healthy controls. Together, these novel findings highlight that ERN may help guide treatment decisions regarding engagement in CBT or SSRIs, especially among individuals with an enhanced ERN. The findings also suggest that SSRIs have the capacity to alter individual differences in the ERN, providing evidence that the ERN is not entirely static in patients with anxiety disorders.

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Section: Assessment Of Psychopathologymentioning

confidence: 79%

Section: Introductionmentioning

confidence: 91%

Section: Assessment Of Psychopathologymentioning

confidence: 99%

Section: Electroencephalogram Data Collection and Processingmentioning

confidence: 99%

Section: Electroencephalogram Data Collection and Processingmentioning

confidence: 99%

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Error-related Brain Activity as a Treatment Moderator and Index of Symptom Change during Cognitive-Behavioral Therapy or Selective Serotonin Reuptake Inhibitors

Gorka

Burkhouse

Klumpp

et al. 2017

Neuropsychopharmacol.

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Neural reactivity to affective stimuli and internalizing symptom dimensions in a transdiagnostic patient sample

Granros

MacNamara

Klumpp

et al. 2022

Depression and Anxiety

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Background: Internalizing psychopathologies (IPs) are highly comorbid and exhibit substantial overlap, such as aberrant affective reactivity. Neural reactivity to emotional images, measured via the late positive potential (LPP) event-related potential (ERP) component, has been utilized to index affective reactivity in IPs. The LPP is often examined in isolation with a specific disorder, ignoring overlap between IPs. The current study examined how transdiagnostic IP symptom dimensions relate to neural affective reactivity in a highly comorbid patient sample. Methods: Participants (N = 99) completed a battery of IP symptom assessments as well as a target categorization task while viewing pleasant, unpleasant, and neutral images during electroencephalography recording. ERPs to each image valence were averaged from 400 to 1000 ms following picture onset at pooled centroparietal and occipital electrodes to calculate the LPP. A principal components analysis performed on the IP symptom measures resulted in two factors: affective distress/ misery and fear-based anxiety.Results: Fear-based anxiety was associated with enhanced LPP reactivity to unpleasant, but not pleasant, images. Distress/misery was related to attenuated average LPP reactivity across images.Conclusions: Results revealed a dissociable effect of IP symptom factors in a transdiagnostic sample such that enhanced reactivity to negative images was specific to enhanced fear-based anxiety symptoms while distress/misery symptoms predicted blunted affective reactivity. Neural affective reactivity may serve as an objective biological marker to elucidate the nature of psychological concerns in individuals with comorbid IPs.

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The moderating role of externalizing problems on the association between anxiety and the error‐related negativity in youth

Suor

Granros

Kujawa

et al. 2020

Developmental Psychobiology

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The error‐related negativity (ERN) is an event‐related potential that reflects error monitoring. Enhanced ERN indicates sensitivity to performance errors and is a correlate of anxiety disorders. In contrast, youth with externalizing problems exhibit a reduced ERN, suggesting decreased error monitoring. Anxiety and externalizing problems commonly co‐occur in youth, but no studies have tested how comorbidity might modulate the ERN. In a sample of youth (N = 46, ages 7–19) with and without anxiety disorders, this preliminary study examined the interactive effect of anxiety and externalizing problems on ERN. Results suggest that externalizing problems moderate the relation between anxiety symptoms and ERN in youth. Anxious youth with less externalizing problems exhibited enhanced ERN response to errors. Conversely, anxious youth with greater externalizing problems demonstrated diminished ERN in response to errors. The regions of significance and proportion affected tests indicated that the moderating the effect of externalizing problems was only significant for youth with anxiety disorders. Findings suggest that enhanced neural error sensitivity could be a specific neurophysiological marker for anxiety disorders, whereas anxious individuals with comorbid externalizing problems demonstrate reduced error monitoring, similar to those with primary externalizing pathology. Results underscore the utility of examining neural correlates of pediatric anxiety comorbidity subtypes.

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Error-related brain activity and internalizing disorder symptom dimensions in depression and anxiety

Cited by 23 publications

References 78 publications

Error-related Brain Activity as a Treatment Moderator and Index of Symptom Change during Cognitive-Behavioral Therapy or Selective Serotonin Reuptake Inhibitors

Error-related Brain Activity as a Treatment Moderator and Index of Symptom Change during Cognitive-Behavioral Therapy or Selective Serotonin Reuptake Inhibitors

Neural reactivity to affective stimuli and internalizing symptom dimensions in a transdiagnostic patient sample

The moderating role of externalizing problems on the association between anxiety and the error‐related negativity in youth

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