Error-related negativity abnormalities in generalized anxiety disorder and obsessive–compulsive disorder

Xiao, Zeping; Wang, Jijun; Zhang, Ming; Li, Hui; Tang, Yingying; Wang, Yuan; Fan, Qing; Fromson, John A.

doi:10.1016/j.pnpbp.2010.11.022

Cited by 116 publications

(107 citation statements)

References 46 publications

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“…Our findings extend a relatively consistent literature reporting increased internal error signals in OCD patients (Gehring et al 2000;Johannes et al 2001;Endrass et al 2008;Gründler et al 2009;Cavanagh et al 2010;Riesel et al 2011;Xiao et al 2011;Endrass & Ullsperger 2014;Riesel et al 2015). This is This might be due to the unclear relation between RPEs and the FRN (Talmi et al 2013;Hauser et al 2014b;Sambrook & Goslin 2014) and the limited spatial specificity of the latter.…”

Section: Discussionsupporting

confidence: 89%

“…Electrophysiological studies further suggest that internal error signals, such as the errorrelated negativity (ERN;Falkenstein et al 1990) are increased in OCD patients (Gehring et al 2000;Johannes et al 2001;Endrass et al 2008;Gründler et al 2009;Cavanagh et al 2010;Riesel et al 2011;Xiao et al 2011;Endrass & Ullsperger 2014;Riesel et al 2015). Although these internal error signals have been related to RPE processing in the ACC (Holroyd & Coles 2002), no study has yet directly investigated RPE signals in OCD patients.…”

Section: Introductionmentioning

confidence: 99%

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Increased fronto-striatal reward prediction errors moderate decision making in obsessive–compulsive disorder

et al. 2017

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Increased fronto-striatal reward prediction errors moderate decision making in obsessive–compulsive disorder

et al. 2017

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“…The presence of PTSD altered neither the electrophysiological nor the behavioral indices of error monitoring, which contrasts with findings in participants with OCD and GAD (Gehring et al, 2000;Endrass and Ullsperger, 2014;Xiao et al, 2011). Specifically, PTSD patients and controls showed no differences in the ERN and Pe components recorded during a flanker interference task, replicating previous results (Rabinak et al, 2013).…”

Section: Discussionsupporting

confidence: 68%

“…Individuals with schizophrenia show reductions in the ERN (Alain et al, 2002;Mathalon et al, 2002), whereas those with generalized anxiety disorder (GAD) and OCD show increases (Gehring et al, 2000;Endrass and Ullsperger, 2014;Xiao et al, 2011). The findings in major depressive disorder are mixed, with some studies showing increases in ERN amplitude (Chiu and Deldin, 2007;Holmes and Pizzagalli, 2008;Aarts et al, 2013) and others decreases (Ruchsow et al, 2006) or no difference (Compton et al, 2008;Schrijvers et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Intact error monitoring in combat Veterans with post-traumatic stress disorder

Swick

Honzel

Turken

2015

Psychiatry Research: Neuroimaging

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The error-related negativity (ERN) is a neuroelectric signature of performance monitoring during speeded response time tasks. Previous studies indicate that individuals with anxiety disorders show ERN enhancements that correlate with the degree of clinical symptomology. Less is known about the error monitoring system in post-traumatic stress disorder (PTSD). PTSD is characterized by impairments in the regulation of fear and other emotional responses, as well as deficits in maintaining cognitive control. Here, combat Veterans with PTSD were compared to control Veterans in two different versions of the flanker task (n=13 or 14 per group). Replicating and extending previous findings, PTSD patients showed an intact ERN in both experiments. In addition, task performance and error compensation behavior were intact. Finally, ERN amplitude showed no relationship with self-reported PTSD, depression, or post-concussive symptoms. These results suggest that error monitoring represents a relative strength in PTSD that can dissociate from cognitive control functions that are impaired, such as response inhibition and sustained attention. A healthy awareness of errors in external actions could be leveraged to improve interoceptive awareness of emotional state. The results could have positive implications for PTSD treatments that rely on self-monitoring abilities, such as neurofeedback and mindfulness training.

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“…Previous work suggests that the CRN magnitude is not associated with anxiety (Moser et al, 2013), and when studies have found a relationship, they have typically found an increased CRN among anxious individuals (Riesel et al, 2011;Xiao et al, 2011). In this context, our finding that anxiety was associated with a smaller (more positive) CRN resid across the sample, as well as the significant interaction between CRN and ERN in predicting GAD status (i.e., among individuals with a small ERN, a small CRN was associated with GAD status) were surprising.…”

Section: Discussionmentioning

confidence: 99%

Considering ERP difference scores as individual difference measures: Issues with subtraction and alternative approaches

et al. 2016

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There is growing interest in psychophysiological and neural correlates of psychopathology, personality, and other individual differences. Many studies correlate a criterion individual difference variable (e.g., anxiety) with a psychophysiological measurement derived by subtracting scores taken from two within-subject conditions. These subtraction-based difference scores are intended to increase specificity by isolating variability of interest. Using data on the error-related negativity (ERN) and correct response negativity (CRN) in relation to generalized anxiety disorder (GAD), we highlight several conceptual and practical issues with subtraction-based difference scores and propose alternative approaches based on regression. We show that ERN and CRN are highly correlated, and that the DERN (i.e., ERN 2 CRN) is correlated in opposite directions both with ERN and CRN. Bivariate analyses indicate that GAD is related to DERN and ERN, but not CRN. We first show that, by using residualized scores, GAD relates both to a larger ERN and smaller CRN. Moreover, by probing the interaction of ERN and CRN, we show that the relationship between GAD and ERN varies by CRN. These latter findings are not evident when using traditional subtraction-based difference scores. We then completed follow-up analyses that suggested that an increased P300 in anxious individuals gave rise to the apparent anxiety/CRN relationship observed. These findings have important conceptual implications for facilitating the interpretability of results from individual difference studies of psychophysiology.

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Error-related negativity abnormalities in generalized anxiety disorder and obsessive–compulsive disorder

Cited by 116 publications

References 46 publications

Increased fronto-striatal reward prediction errors moderate decision making in obsessive–compulsive disorder

Increased fronto-striatal reward prediction errors moderate decision making in obsessive–compulsive disorder

Intact error monitoring in combat Veterans with post-traumatic stress disorder

Considering ERP difference scores as individual difference measures: Issues with subtraction and alternative approaches

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