Error-Related Negativity and Tic History in Pediatric Obsessive-Compulsive Disorder

Hanna, Gregory L.; Carrasco, Melisa; Harbin, Shannon M.; Nienhuis, Jenna K.; LaRosa, Christina E.; Chen, Po‐Yu; Fitzgerald, Kate D.; Gehring, William J.

doi:10.1016/j.jaac.2012.06.019

Cited by 74 publications

(72 citation statements)

References 53 publications

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“…The localization of greater OCD severity with greater FA in the anterior cingulum bundle links to prior task-based research using functional MRI and event-related potentials to demonstrate hyperactivity of the ACC in response to errors in children and adults with OCD 36, 37 and related theory that ACC-based hypersensitivity to errors could drive repetitive attempts to correct perceived mistakes in patients 38 . Theoretically, increased white matter microstructure might drive or result from greater signaling through FSTC that, on the basis of abnormally increased metabolism and resting state connectivity, has been hypothesized to underlie OCD 1, 9 .…”

Section: Discussionsupporting

confidence: 55%

Atypical Frontal–Striatal–Thalamic Circuit White Matter Development in Pediatric Obsessive-Compulsive Disorder

Fitzgerald¹,

Liu²,

Reamer³

et al. 2014

Journal of the American Academy of Child & Adolescent Psych

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Objective Atypical development of frontal-striatal-thalamic circuitry (FSTC) has been hypothesized to underlie the early course of obsessive-compulsive disorder (OCD); however, the development of FSTC white matter tracts remains to be studied in young patients. Method To address this gap, we scanned 36 patients with pediatric OCD compared to 27 healthy controls, aged 8 to 19 years, with diffusion tensor imaging (DTI) to measure fractional anisotropy (FA), an index of white matter coherence. Tract-based spatial statistics (TBSS) were used to test differential effects of age on FA, across the whole brain, in those with OCD compared to healthy youth, followed by analyses in a priori regions of interest (anterior corpus callosum, anterior cingulum bundle and anterior limb of the internal capsule [ALIC]) to further characterize developmental differences between groups. Results Patients with OCD showed more pronounced age-related increases in FA than controls in regions of interest, as well as several other white matter tracts. In patients, greater FA in anterior cingulum bundle correlated with more severe symptoms after controlling for age. Conclusions Our findings support theories of atypical FSTC maturation in pediatric OCD by providing the first evidence for altered trajectories of white matter development in anterior corpus callosum, anterior cingulum bundle, and ALIC in young patients. Steeper age-related increases of FA in these and other select white matter tracts in OCD, compared to healthy controls, may derive from an early delay in white matter development and/or prolonged white matter growth, but confirmation of these possibilities awaits longitudinal work.

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Section: Discussionsupporting

confidence: 55%

Atypical Frontal–Striatal–Thalamic Circuit White Matter Development in Pediatric Obsessive-Compulsive Disorder

Fitzgerald¹,

Liu²,

Reamer³

et al. 2014

Journal of the American Academy of Child & Adolescent Psych

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“…It is possible that findings would differ in a sample of children presenting with primary tics who have co-occurring OCD, or in those who have another primary co-occurring disorder. It is also possible that characteristics that are unique to tic-related OCD were not measured, and that these factors may have an impact on treatment outcome (e.g., neurobiological functioning 25 ). Finally, youth with tics+OCD were less common at the UPenn site, which is likely attributable to that site's recruiting for a concurrent study on tics.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, a recent study that defined pediatric tic-related OCD more inclusively (co-occurrence with chronic tic disorders plus transient tic disorder and tic disorder not otherwise specified [NOS]) found greater error-related brain activity in non-tic-related than tic-related OCD. 25 …”

Section: Introductionmentioning

confidence: 99%

Tic-Related Obsessive-Compulsive Disorder (OCD): Phenomenology and Treatment Outcome in the Pediatric OCD Treatment Study II

Conelea

Walther

Freeman

et al. 2014

Journal of the American Academy of Child & Adolescent Psych

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Objective Prior research has shown that youth with co-occurring tic disorders and obsessive-compulsive disorder (OCD) may differ from those with non-tic-related OCD in terms of clinical characteristics and treatment responsiveness. A broad definition of “tic-related” was used to examine whether children with tics in the Pediatric OCD Treatment Study II differed from those without tics in terms of demographic and phenomenological characteristics and acute treatment outcome. Method Participants were 124 youth aged 7-17 years with a primary diagnosis of OCD who were partial responders to an adequate serotonin reuptake inhibitor (SRI) trial. Participants were randomized to medication management, medication management plus instructions in cognitive behavioral therapy (CBT), or medication management plus full CBT. Tic status was based on the presence of motor and/or vocal tics on the Yale Global Tic Severity Scale. Results Tics were identified in 53% of the sample. Those with tic-related OCD did not differ from those with non-tic-related OCD in terms of age, family history of tics, OCD severity, OCD-related impairment, or comorbidity. Those with tics were responded equally in all treatment conditions. Conclusion Tic-related OCD was very prevalent using a broad definition of tic status. Results suggest that youth with this broad definition of tic-related OCD do not have increased OCD severity or inference, higher comorbidity rates or severity, or worsened functioning and support the use of CBT in this population. This highlights the importance of not making broad assumptions about OCD symptoms most likely to occur in an individual with comorbid tics. Clinical trial registration information--Treatment of Pediatric OCD for SRI Partial Responders; http://clinicaltrials.gov/show/; NCT00074815.

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“…Neurobiological differences by tic status might account for differential treatment response, as youth with non-tic-related OCD have shown larger error-related negativity than youth with tic-related OCD [62].…”

Section: Cbt and Medicationmentioning

confidence: 99%

Personalizing the Treatment of Pediatric Obsessive-Compulsive Disorder: Evidence for Predictors and Moderators of Treatment Outcomes

Caporino

Storch

2016

Curr Behav Neurosci Rep

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Cognitive behavioral therapy (CBT), delivered alone or with a serotonin reuptake inhibitor (SRI), is efficacious for treating pediatric obsessive-compulsive disorder (OCD), but not all youth respond optimally. Research to understand for whom a given intervention is beneficial can inform efforts to personalize treatment or tailor it to specific youths to enhance outcomes. We review studies that examined potential predictors/moderators of response to CBT, medication, and multimodal treatment for pediatric OCD: demographics, disorder-specific characteristics, general illness characteristics, neuropsychological functioning, biomarkers, family factors, and non-specific therapy factors. Methodological differences across studies make it challenging to synthesize findings and more research with large samples is needed. However, family factors have emerged as relatively consistent and strong predictors of treatment outcomes and there is preliminary support for attention to the presence of tics in treatment selection. There is little evidence for age and other demographic differences in treatment response.

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Error-Related Negativity and Tic History in Pediatric Obsessive-Compulsive Disorder

Cited by 74 publications

References 53 publications

Atypical Frontal–Striatal–Thalamic Circuit White Matter Development in Pediatric Obsessive-Compulsive Disorder

Atypical Frontal–Striatal–Thalamic Circuit White Matter Development in Pediatric Obsessive-Compulsive Disorder

Tic-Related Obsessive-Compulsive Disorder (OCD): Phenomenology and Treatment Outcome in the Pediatric OCD Treatment Study II

Personalizing the Treatment of Pediatric Obsessive-Compulsive Disorder: Evidence for Predictors and Moderators of Treatment Outcomes

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