Error-related neural activity and alcohol use disorder: Differences from risk to remission

Gorka, Stephanie M.; Lieberman, Lynne; Kreutzer, Kayla A.; Carrillo, Vivian; Weinberg, Anna; Shankman, Stewart A.

doi:10.1016/j.pnpbp.2019.01.011

Cited by 18 publications

(12 citation statements)

References 55 publications

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“…The ERN has also been found to predict relapse in cocaine users (99). ERN findings in alcohol dependence are more mixed, with some studies reporting enhanced ERN potentially due to comorbid anxiety (100,101), and others an attenuated ERN in line with other types of addictions (102).…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Midfrontal Theta Activity in Psychiatric Illness: An Index of Cognitive Vulnerabilities Across Disorders

McLoughlin

Gyurkovics

Palmer

et al. 2022

Biological Psychiatry

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Midfrontal Theta Activity in Psychiatric Illness: An Index of Cognitive Vulnerabilities Across Disorders

McLoughlin

Gyurkovics

Palmer

et al. 2022

Biological Psychiatry

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“…In a longitudinal study using a Flanker task, adolescents, who consumed tobacco later in early adulthood, displayed reduced amplitudes at ages 14 and 16 and slower developmental ERN changes suggesting that an impaired error monitoring could predict development of addictive behaviour (Anokhin and Golosheykin 2015). These findings are further supported by studies with individuals having a family history of SUD and are therefore at risk also to develop an addiction: offspring of cannabis consumers (Euser et al 2013) and alcoholics have been shown to display reduced ERN similar to already addicted individuals, supporting the ERN as an indicator of disease status (Gorka et al 2019). Also in cocainedependent patients vs. controls reduced ERN amplitudes in a Flanker task have been shown to reliably predict relapse within 3-month (Marhe et al 2013).…”

Section: Ernmentioning

confidence: 57%

Biomarkers and neuromodulation techniques in substance use disorders

et al. 2020

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Addictive disorders are a severe health concern. Conventional therapies have just moderate success and the probability of relapse after treatment remains high. Brain stimulation techniques, such as transcranial Direct Current Stimulation (tDCS) and Deep Brain Stimulation (DBS), have been shown to be effective in reducing subjectively rated substance craving. However, there are few objective and measurable parameters that reflect neural mechanisms of addictive disorders and relapse. Key electrophysiological features that characterize substance related changes in neural processing are Event-Related Potentials (ERP). These high temporal resolution measurements of brain activity are able to identify neurocognitive correlates of addictive behaviours. Moreover, ERP have shown utility as biomarkers to predict treatment outcome and relapse probability. A future direction for the treatment of addiction might include neural interfaces able to detect addiction-related neurophysiological parameters and deploy neuromodulation adapted to the identified pathological features in a closed-loop fashion. Such systems may go beyond electrical recording and stimulation to employ sensing and neuromodulation in the pharmacological domain as well as advanced signal analysis and machine learning algorithms. In this review, we describe the state-of-the-art in the treatment of addictive disorders with electrical brain stimulation and its effect on addiction-related neurophysiological markers. We discuss advanced signal processing approaches and multi-modal neural interfaces as building blocks in future bioelectronics systems for treatment of addictive disorders.

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“…For example, adolescent anxiety and externalizing comorbidity is associated with increased risk for alcohol and substance abuse problems (e.g., Egerton et al, 2020), although some research has found protective effects of anxiety (e.g., Colder et al, 2017). With respect to the neuropsychological literature, some studies have indicated that adults with substance use disorders (SUD) demonstrate a decreased ERN (Franken, Ivan Strien, Franzek, & van de Wetering, 2007; Luijten et al, 2014), a relationship that has been extended to cocaine abuse (Franken et al, 2007; Morie, De Sanctis, Garavan, & Foxe, 2014; Sokhadze, Stewart, Hollifield, & Tasman 2008), smoking (Luijten, van Meel, & Franken, 2011), and current alcohol use and abuse (Bartholow, Henry, Lust, Saults, & Wood, 2012; Gorka et al, 2019; Smith & Mattick, 2013). The extent to which ERN and alcohol and substance abuse patterns are predicted by anxiety and externalizing comorbidities with childhood onset is unknown.…”

Section: Discussionmentioning

confidence: 99%

The moderating role of externalizing problems on the association between anxiety and the error‐related negativity in youth

Suor

Granros

Kujawa

et al. 2020

Developmental Psychobiology

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The error‐related negativity (ERN) is an event‐related potential that reflects error monitoring. Enhanced ERN indicates sensitivity to performance errors and is a correlate of anxiety disorders. In contrast, youth with externalizing problems exhibit a reduced ERN, suggesting decreased error monitoring. Anxiety and externalizing problems commonly co‐occur in youth, but no studies have tested how comorbidity might modulate the ERN. In a sample of youth (N = 46, ages 7–19) with and without anxiety disorders, this preliminary study examined the interactive effect of anxiety and externalizing problems on ERN. Results suggest that externalizing problems moderate the relation between anxiety symptoms and ERN in youth. Anxious youth with less externalizing problems exhibited enhanced ERN response to errors. Conversely, anxious youth with greater externalizing problems demonstrated diminished ERN in response to errors. The regions of significance and proportion affected tests indicated that the moderating the effect of externalizing problems was only significant for youth with anxiety disorders. Findings suggest that enhanced neural error sensitivity could be a specific neurophysiological marker for anxiety disorders, whereas anxious individuals with comorbid externalizing problems demonstrate reduced error monitoring, similar to those with primary externalizing pathology. Results underscore the utility of examining neural correlates of pediatric anxiety comorbidity subtypes.

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Error-related neural activity and alcohol use disorder: Differences from risk to remission

Cited by 18 publications

References 55 publications

Midfrontal Theta Activity in Psychiatric Illness: An Index of Cognitive Vulnerabilities Across Disorders

Midfrontal Theta Activity in Psychiatric Illness: An Index of Cognitive Vulnerabilities Across Disorders

Biomarkers and neuromodulation techniques in substance use disorders

The moderating role of externalizing problems on the association between anxiety and the error‐related negativity in youth

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