Error signals in the subthalamic nucleus are related to post-error slowing in patients with Parkinson's disease

Siegert, Sandy; Ruiz, María Herrojo; Brücke, Christof; Huebl, Julius; Schneider, Gerd‐Helge; Ullsperger, Markus; Kühn, Andrea A.

doi:10.1016/j.cortex.2013.12.008

Cited by 43 publications

(44 citation statements)

References 119 publications

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“…Regarding the putative target of these frontal nodes, two other studies of PES recorded the STN-LFP in DBS patients (Cavanagh et al, 2014; Siegert et al, 2014). Both studies showed that STN activity was increased following errors, and related to PES on the next trial (the studies differ slightly in the time window at which they identify STN activity that predicts PES; Siegert et al showed that the phase-locked LFP at around 300ms following the erroneous response correlated with PES, while Cavanagh et al showed that the event-related spectral perturbations in the theta frequency immediately before the next response related to PES).…”

Section: Role Of Global Stopping Network In Slowing After Unexpected mentioning

confidence: 99%

On the Globality of Motor Suppression: Unexpected Events and Their Influence on Behavior and Cognition

Wessel

Aron

2017

Neuron

385

382

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SUMMARY Unexpected events are part of everyday experience. They come in several varieties – action errors, unexpected action outcomes, and unexpected perceptual events – and they lead to motor slowing and cognitive distraction. While different varieties of unexpected events have been studied largely independently, and many different mechanisms are thought to explain their effects on action and cognition, we suggest a unifying theory. We propose that unexpected events recruit a fronto-basal-ganglia network for stopping. This network includes specific prefrontal cortical nodes and is posited to project to the subthalamic nucleus, with a putative global suppressive effect on basal-ganglia output. We argue that unexpected events interrupt action and impact cognition, partly at least, by recruiting this global suppressive network. This provides a common mechanistic basis for different types of unexpected events, links the literatures on motor inhibition, performance-monitoring, attention, and working memory, and is relevant for understanding clinical symptoms of distractibility and mental inflexibility.

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Section: Role Of Global Stopping Network In Slowing After Unexpected mentioning

confidence: 99%

On the Globality of Motor Suppression: Unexpected Events and Their Influence on Behavior and Cognition

Wessel

Aron

2017

Neuron

385

382

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“…The studies which compared drug-naive PD patients with chronically medicated PD patients did not report Ne/ERN amplitude differences between these groups, neither when the latter patients were on medication (Stemmer et al, 2007) nor when they were off medication (Beste et al, 2009b) during testing. In a more recent study, Siegert et al (2014) found differential effects of dopaminergic therapy on task performance in a flanker task depending on the patients' age and disease onset, supporting a dopamine overdose effect in younger patients with early onset of PD; these behavioral changes corresponded to the modulation of Ne/ERN amplitudes.…”

Section: Ne/ern and Dopaminergic Medication In Pdmentioning

confidence: 99%

“…Such studies may help to reveal the role of the stimulated basal ganglia nuclei for specific cognitive processes and their ERP correlates. In addition, DBS allows for electrophysiological recordings directly from the stimulated site (i.e., the recording of local field potentials; e.g., Siegert et al, 2014) and thus provides the possibility to examine electrophysiological correlates of cognitive processes at the level of neuronal populations (Münte et al, 2008). …”

Section: General Conclusion Open Questions and Directions For Futumentioning

confidence: 99%

Event-related potentials and cognition in Parkinson’s disease: An integrative review

Seer

Lange

Georgiev

et al. 2016

Neuroscience & Biobehavioral Reviews

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“…Our results suggest that rIFG implements memoryreliant inhibitory processes after negative feedback in particular as indicated by our fMRI results and thus plays a role in generating the post-error slowing. Unlike tasks that require immediate error correction, such as the classical Eriksen Flanker task (Siegert et al, 2014) or a Simon task (e.g., Danielmeier, Eichele, Forstmann, Tittgemeyer, & Ullsperger, 2011;King, Korb, von Cramon, & Ullsperger, 2010), feedback has little conceptual meaning for the immediate subsequent pair-unspecific trial in the current reinforcement learning task. Previously, no speed adjustments have been found on the direct next trial (Cavanagh et al, 2010;Frank et al, 2007), and we even find post-error speeding on the direct next trial.…”

Section: Pair-specific Post-error Slowingmentioning

confidence: 99%

Memory-reliant Post-error Slowing Is Associated with Successful Learning and Fronto-occipital Activity

Schiffler

Almeida

Granqvist

et al. 2016

Journal of Cognitive Neuroscience

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Abstract■ Negative feedback after an action in a cognitive task can lead to devaluing that action on future trials as well as to more cautious responding when encountering that same choice again. These phenomena have been explored in the past by reinforcement learning theories and cognitive control accounts, respectively. Yet, how cognitive control interacts with value updating to give rise to adequate adaptations under uncertainty is less clear. In this fMRI study, we investigated cognitive control-based behavioral adjustments during a probabilistic reinforcement learning task and studied their influence on performance in a later test phase in which the learned value of items is tested. We provide support for the idea that functionally relevant and memory-reliant behavioral adjustments in the form of post-error slowing during reinforcement learning are associated with test performance. Adjusting response speed after negative feedback was correlated with BOLD activity in right inferior frontal gyrus and bilateral middle occipital cortex during the event of receiving the feedback. Bilateral middle occipital cortex activity overlapped partly with activity reflecting feedback deviance from expectations as measured by unsigned prediction error. These results suggest that cognitive control and feature processing cortical regions interact to implement feedback-congruent adaptations beneficial to learning. ■

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Error signals in the subthalamic nucleus are related to post-error slowing in patients with Parkinson's disease

Cited by 43 publications

References 119 publications

On the Globality of Motor Suppression: Unexpected Events and Their Influence on Behavior and Cognition

On the Globality of Motor Suppression: Unexpected Events and Their Influence on Behavior and Cognition

Event-related potentials and cognition in Parkinson’s disease: An integrative review

Memory-reliant Post-error Slowing Is Associated with Successful Learning and Fronto-occipital Activity

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