Erste Enantiomerentrennung eines freien P‐chiralen Fluorphosphans

Abstract

In optisch reiner Form ([α] D20=‐210) kann (Sp)‐ (‐)‐1 aus einem konfigurationsisomerenreinen Palladium(II)‐Komplex freigesetzt werden, der das Phosphan und ortho‐metalliertes (R)‐(‐)‐[1‐(Dimethylamino)ethyl]naphthalin enthält. Bei 20°C racemisiert das Phosphan in 6 h ohne nennenswerte Disproportionierung.

Enantioselective Synthesis of Phosphine Boranes via Crystallization‐Induced Dynamic Resolution of Lithiated Intermediate by Understanding the Underlying Epimerization Process

“…[5] In the special case of the preferred crystallization of one intermediate, one can consider this process as crystallization-induced dynamic resolution (CIDR). [6,7] Even though the above mentioned approaches result in highly enriched products and good yields, the purification of stereoisomers can be challenging. [8] Also, for chelating diastereomeric phosphorus ligands (e.g.…”