Ertapenem compared to combination drug therapy for the treatment of postpartum endometritis after cesarean delivery

Abstract

Although time and number of administered doses were less in group A, given the high wound complication rate in patients treated with ertapenem, this drug may not be appropriate for all patients with endometritis after CD.

Post partum infections: A review for the non-OBGYN

“…19 A more recent comparison of combination therapy with clindamycin and gentamicin (plus or minus ampicillin) against ertapenum showed similar treatment outcomes and length of stay but higher cost and higher rate of wound dehiscence for the ertapenem group. 23…”

“…23 Parenteral therapy should be continued until patient becomes afebrile (temperature 537. 5 C for 24 h), pain improves, and the leukocyte count normalizes.…”

Principles of Anti-infective Dosing in Pregnancy

“…However, evidence of the efficacy of ertapenem is conflicting and further studies are needed. 44,45 As bacterial resistance to antibiotics continues to evolve and newer antibiotics become available, there will be a need for additional trials to determine antibiotic regimens appropriate for the obstetric patient.…”

Immunomodulatory drugs in the treatment of postpartum endometritis

“…При тяжелой форме эндометрита для монотерапии назначают цефалоспорины III поколения (цефоперазон, цефтазидим, цефоперазон/сульбактам), фторхинолоны (моксифлоксацин) и карбапенемы (имипенем/циластатин или меропенем) [10,18].…”