Eruption abnormalities in permanent molars: differential diagnosis and radiographic exploration

Cohen-Lévy, Julia; Cohen, N.

doi:10.1051/odfen/2014054

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…The data were collected at 4 time points to observe the progression of the condition: (a) half root formation at postnatal day (P) 14, (b) completion of molar root formation and tooth eruption at P25, (c) fully grown mice at P91, and (d) middle‐aged mice at P182. Similar to human PFE conditions, PPR cKO molars exhibited delayed tooth eruption, tooth root anomalies, and defective interradicular bones (Cohen‐Lévy & Cohen, ; Deffrennes & Cohen‐Lévy, ; Pilz et al, ; Figure ). The statistical analysis revealed that the eruption height of cKO first and second molars (Figure i,j red line) was significantly lower than that of Control and cHet molars (Figure i,j black and blue line, respectively), starting from P25 to P182.…”

Section: Resultsmentioning

confidence: 89%

“…In addition, coronal superimposition images show that cKO molars unanimously have truncated and dilacerated roots. These morphological root anomalies of mouse PFE molars are reminiscent of those observed in human PFE molars, which are associated with tooth root abnormality and normal crown morphology (Cohen‐Lévy & Cohen, ; Deffrennes & Cohen‐Lévy, ; Pilz et al, ). Furthermore, there is a significant reduction of the interradicular bone height in cKO first and second molars at P182, indicating defective bone formation in this specific area.…”

Section: Discussionmentioning

confidence: 88%

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A three‐dimensional analysis of primary failure of eruption in humans and mice

et al. 2019

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Objectives Primary failure of eruption (PFE) is a genetic disorder exhibiting the cessation of tooth eruption. Loss‐of‐function mutations in parathyroid hormone (PTH)/parathyroid hormone‐related peptide (PTHrP) receptor (PTH/PTHrP receptor, PPR) were reported as the underlying cause of this disorder in humans. We showed in a PFE mouse model that PTHrP‐PPR signaling is responsible for normal dental follicle cell differentiation and tooth eruption. However, the mechanism underlying the eruption defect in PFE remains undefined. In this descriptive study, we aim to chronologically observe tooth eruption and root formation of mouse PFE molars through 3D microCT analyses. Setting and Sample Population Two individuals with PFE were recruited at Showa University. A mouse PFE model was generated by deleting PPR specifically in PTHrP‐expressing dental follicle and divided into three groups, PPRfl/fl;R26RtdTomato/+(Control), PTHrP‐creER;PPRfl/+;R26RtdTomato/+(cHet), and PTHrP‐creER;PRRfl/fl;R26RtdTomato/+(cKO). Materials and Methods Images from human PFE subjects were acquired by CBCT. All groups of mouse samples were studied at postnatal days 14, 25, 91, and 182 after a tamoxifen pulse at P3, and superimposition of 3D microCT images among three groups was rendered. Results Mouse and human PFE molars exhibited a similar presentation in the 3D CT analyses. The quantitative analysis in mice demonstrated a statistically significant decrease in the eruption height of cKO first and second molars compared to other groups after postnatal day 25. Additionally, cKO molars demonstrated significantly shortened roots with dilacerations associated with the reduced interradicular bone height. Conclusions Mouse PFE molars erupt at a much slower rate compared to normal molars, associated with shortened and dilacerated roots and defective interradicular bones.

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Section: Resultsmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 88%

A three‐dimensional analysis of primary failure of eruption in humans and mice

et al. 2019

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“…[2] This local process is regulated by genes expressing in the dental follicle, at critical periods following a precise chronology, bilaterally coordinated with facial growth. [ 3] Unlike the third molars, in first and second permanent molars eruption abnormalities are relatively rare, estimated at 0.06% by Prece and Grover reported similar prevalence, at 0.08% for second maxillary molars and 0.01% for first mandibular molars. [ 3] More recently, considerably higher prevalence rates were reported in retrospective studies based on orthodontic consultation records: 2.3% for second molar eruption abnormalities as a whole, comprising 1.5% ectopic eruption, 0.2% impaction and 0.6% primary failure of eruption (PFE), and up to 1.36% permanent second molar iimpaction according to Cassetta et al [4] Second molar retention is generally discovered serendipitously, being asymptomatic in 68.5% of cases.…”

Section: Introductionmentioning

confidence: 99%

The The eruption phase of second permanent molar in children aged 11-15 years in coastal area of pugerIndonesia

Probosari,

Berlian Prihatiningrum,

Mulyani

et al. 2024

IJDR

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Background : The first permanent teeth that erupt in the oral cavity is the first permanent molar, which has a high risk of extraction due to caries. Functionally, permanent second molars can replace the function of permanent first molars. Permanent second molars erupt at the age of 11-15 years. The eruption of teeth can be influenced by environmental factors. One of the environmental factors is the geographical conditions. Geographical conditions, such as in coastal areas, will affect the economic conditions and consumption patterns of people living in the area, so it is possible that this can affect tooth eruption. Aims and Objectives : This study aimed to examine the eruption phase of the second permanent molar in children aged 11-15 in the coastal Puger district, Jember. Study Design : This study is a descriptive observational study with a cross-sectional approach. Materials and Methods: The sample was 100 pairs of study models of children aged 11-15 years who lived on the coastal area of Puger. Results : Observed eruption phase of permanent second molars in maxillary and mandibular study models and classified into four phases: 0.00 = tooth not erupted, 0.25 = cusp erupted until quarter of the height of the tooth is erupted, 0.50 = half of the height of the tooth is erupted, 1.00 = tooth has more than half until the whole clinical crown erupted. Conclusion : The results showed that the children on the Puger coast had a faster eruption time, in addition, the mandibular teeth erupted earlier than the maxillary teeth and needed 3 years to reach full eruption.

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The tooth eruption and its abnormalities - A narrative review

Charan

Sangeetha

Santana

et al. 2022

SRM Journal of Research in Dental Sciences

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Background: The process of tooth eruption is influenced by local, systemic, and genetic factors. Any disturbances in these factors might lead to abnormalities in the eruption of the tooth. Aim: The aim of this narrative review is to classify and discuss the eruption and its abnormality in detail. Methods: This narrative review was performed through an electronic search of data for the articles dealing with eruption, theories of eruption, and eruption abnormalities from the following databases such as PubMed, Scopus, Medknow, WebMD, and IndMed. Results: Based on our search, we were able to retrieve the information from 15 articles. Conclusion: A mastered eye in evaluating the radiographs, the practitioner's acquaintance with associated abnormalities, and the patient's clear history including familial and traumatic history might pave the way in arriving at an approximate diagnosis.

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Eruption abnormalities in permanent molars: differential diagnosis and radiographic exploration

Cited by 3 publications

References 24 publications

A three‐dimensional analysis of primary failure of eruption in humans and mice

A three‐dimensional analysis of primary failure of eruption in humans and mice

The The eruption phase of second permanent molar in children aged 11-15 years in coastal area of pugerIndonesia

The tooth eruption and its abnormalities - A narrative review

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