Eruptive acral lentiginosis following chemotherapy for acute lymphoblastic leukemia: A case series

Abstract

Lentigines are brown macules which develop due to increased proliferation of melanocytes at the dermo‐epidermal junction. We report three cases of acral lentiginosis in children following chemotherapy for acute lymphoblastic leukaemia (ALL) which have persisted following cessation of chemotherapy, despite avid photoprotection. Generalised eruptive naevi with subsequent development of dysplastic naevi and melanoma in situ have been reported following chemotherapy, highlighting the importance of continued clinical observation.

Eruptive Acral Nevi Secondary to Treatment With Chemotherapy

“…3 Eruptive nevi in these cases were documented to persist following cessation of treatment with chemotherapy and years into remission. 3 The specific distribution of eruptive nevi at acral regions has been shown to be associated with current and past states of immune suppresion. 4 Treatment of eruptive nevi is not necessary, as they are primarily benign lesions.…”

“…Acral eruptive nevi have been documented in similar cases of pediatric acute lymphoblastic leukemia in which patients were prescribed immunosuppressive medications as maintenance therapy . Eruptive nevi in these cases were documented to persist following cessation of treatment with chemotherapy and years into remission . The specific distribution of eruptive nevi at acral regions has been shown to be associated with current and past states of immune suppresion …”