Eruptive disseminated Spitz nevi in a 26‐year‐old African‐American woman

Mazzurco, Jason D.; Menssen, Kate; Schapiro, Brian; Ramirez, James; Heidelberg, Karen

doi:10.1111/j.1365-4632.2010.04695.x

Cited by 10 publications

(12 citation statements)

References 8 publications

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“…The scalp, mucous membranes, palms and soles are usually spared. In the EDSN is possible to observe the development of more than 100 Spitz nevi, over a period of several months or years [ 6 , 7 ]. To best of our knowledge only 15 cases of EDSN have been described in literature [ 7 – 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…In the EDSN is possible to observe the development of more than 100 Spitz nevi, over a period of several months or years [ 6 , 7 ]. To best of our knowledge only 15 cases of EDSN have been described in literature [ 7 – 9 ]. Generally, on dermoscopy the Spitz nevi shows three dermoscopic patterns: starburst, globular and multicomponent [ 3 , 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…The typical aspects of Spitz nevi at RCM were previously described [ 4 ]. The cause of EDSN is still unknown, although a number of possible precipitating factors have been described in the literature, including pregnancy, intravenous drug abuse, perioperative stress, Addison disease, ultraviolet light exposure and fever following tonsillectomy [ 7 , 12 ]. After chemotherapy a conspicuous eruption of multiple nevi has been reported in literature [ 13 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…Surgical removal of individual melanocytic lesions is possible but, due to the large number and poor cosmetic results, is not considered a good option for EDSN. Other treatment options adopted in the past are the liquid nitrogen, electrocoagulation and imiquimod [ 7 , 15 ]. However, there is no satisfactory treatment for EDSN.…”

Section: Discussionmentioning

confidence: 99%

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Congenital Glioblastoma multiforme and eruptive disseminated Spitz nevi

et al. 2016

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BackgroundGlioblastoma multiforme (GBM) is the deadliest malignant primary brain tumor in adults. GBM develops primarily in the cerebral hemispheres but can develop in other parts of the central nervous system. Its congenital variant is a very rare disease with few cases described in literature.Case presentationWe describe the case of a patient with congenital GBM who developed eruptive disseminated Spitz nevi (EDSN) after chemotherapy. Few cases of EDSN have been described in literature and this rare clinical variant, which occurs predominantly in adults, is characterized by multiple Spitz nevi in the trunk, buttocks, elbows and knees. There is no satisfactory treatment for EDSN and the best therapeutic choice is considered the clinical observation of melanocytic lesions.ConclusionWe recommend a close follow-up of these patients with clinical observation, dermoscopy and reflectance confocal microscopy (RCM). However, we suggest a surgical excision of the lesions suspected of being malignant.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Congenital Glioblastoma multiforme and eruptive disseminated Spitz nevi

et al. 2016

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“…1,2 Very rare cases have been reported in African Americans and Asians. [1][2][3][4] Only one case of erupted disseminated Spitz nevi in an African American has been reported. 4 Because of the rarity and variable presentation of Spitz nevi in African Americans, we aimed to compile and study the cases seen at our institution.…”

Section: Introductionmentioning

confidence: 99%

Spitz nevi in African Americans: A retrospective chart review of 11 patients

Honda

2020

J Cutan Pathol

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Background: Spitz nevi are benign melanocytic neoplasms that typically present as rapidly growing solitary lesions on the head, neck, or lower extremities. Very rare reports have been described in African Americans. Methods: A single-institution 29-year retrospective review of African American patients diagnosed with Spitz nevi was thoroughly analyzed in order to characterize these rare clinical and histopathologic presentations. Results: Eleven African Americans with spitzoid lesions were identified. Seven (64%) cases were in pediatric patients and nine (82%) were in females. Most lesions were hyperpigmented (73%) and elevated (82%). Six (55%) were compound Spitz nevi, three (27%) were dermal Spitz nevi, and two (18%) were junctional Spitz nevi. Two lesions had more than one atypical feature. Histopathologically, common features were symmetry, sharp circumscription, pagetoid spread (55%) with most being centrally, predominance of epithelioid cells (64%), Kamino bodies (45%), slight pigmentation (46%), maturation of dermal component with depth, and lack of subcutaneous fat involvement or ulceration. Excision was performed on all patients and there were no recurrences although follow-up was limited. Conclusion: Awareness of the possibility and various presentations of Spitz nevi in African Americans will help prevent misdiagnosis.

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