Eruptive Keratoacanthoma With an Internal Malignant Neoplasm

Snider, B. Leonard

doi:10.1001/archderm.1981.01650120034017

Cited by 30 publications

(5 citation statements)

References 24 publications

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“…Several associated conditions have been reported consisting of autoimmune diseases (Sjögren's syndrome, systemic lupus erythematosus) and internal malignancies (asymptomatic ovarian carcinoma, metastasizing carcinoma of the fallopian tube, stem cell leukemia, metastatic colon cancer) . So far, the present case is the first report in the published work about GEKA with vitiligo, which reveals that immunity may play an important role in GEKA.…”

Section: Discussionsupporting

confidence: 51%

Generalized eruptive keratoacanthoma with vitiligo followed by the development of prurigo nodularis: A case report and published work review

Zhang

et al. 2017

The Journal of Dermatology

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Herein, we report a unique case of generalized eruptive keratoacanthoma (GEKA) in a 47-year-old Chinese man presenting with extensive pruritic papules and nodules accompanied by oral lesions. He also had a 2-year history of vitiligo and long-term experience of working outdoors. Biopsies were consistent with keratoacanthoma . Interestingly, prurigo nodularis (PN) was found in histopathology at 1-year follow up. To our knowledge, this is the first report describing a case of GEKA with oral lesions complicated with vitiligo and developed with PN.

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Section: Discussionsupporting

confidence: 51%

Generalized eruptive keratoacanthoma with vitiligo followed by the development of prurigo nodularis: A case report and published work review

Zhang

et al. 2017

The Journal of Dermatology

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“…An association of KA with HPVs was however not convincingly shown and never reported for generalized KA of Grzybowski. Nor has a linkage of eruptive KA with systemic disease been documented, although single patients had associated internal malignancies [23, 24, 25]. …”

Section: Discussionmentioning

confidence: 99%

Generalized Eruptive Keratoacanthoma of Grzybowski: Follow-Up of the Original Description and 50-Year Retrospect

Schwartz

Błaszczyk²,

Jabłońska³

2002

Dermatology

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We report a follow-up of the original case of eruptive multiple keratoacanthoma (KA) described by Grzybowski in 1950 which did not show malignant transformation within 16 years after the onset of the disease in spite of a very widespread cutaneous involvement. There was no associated internal malignancy or any systemic disease either, and the patient died of a myocardial infarction unrelated to his cutaneous disorder. This case followed up for such a long time provides further confirmation that this variety of KA does not show invasive growth and usually does not progress into squamous cell carcinoma

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“…Lastly , GEKA has been reported in association with internal malignancy such as ovarian and fallopian tube carcinoma . It has also been demonstrated in association with latent syphilis, haemolytic anaemia and systemic lupus erythematosus.…”

Section: Pathogenesismentioning

confidence: 94%

“…Generalized eruptive keratoacanthoma (GEKA) is an extremely rare variant of multiple KA affecting the skin and mucous membranes. It was first described by Grzybowski in 1950; since then about 37 cases have been added to the literature …”

Section: Introductionmentioning

confidence: 99%

Generalized eruptive keratoacanthoma: proposed diagnostic criteria and therapeutic evaluation

Nofal

Assaf

Nofal

et al. 2013

Acad Dermatol Venereol

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Generalized eruptive keratoacanthoma (GEKA) of Grzybowski is a sporadically occurring, extremely rare variant of keratoacanthoma characterized clinically by severely pruritic, generalized eruption of numerous small follicular papules, often with a central keratotic plug, and histologically by typical features of solitary keratoacanthoma. Despite the continuous addition of new case reports, no definite diagnostic criteria have been established, and an optimum treatment is not yet determined. Herein, we review the different aspects of this rare entity, including pathogenesis, clinical and histopathological features, differential diagnosis, course and prognosis. Different therapeutic approaches and their impact on the course and prognosis of the disease are also evaluated and presented. We propose two sets of diagnostic criteria to define the disease more precisely and to avoid overlapping and confusion with other types of multiple keratoacanthoma. The first set comprises constant clinical and histopathological features that almost always present in every case and the second set includes variable features that were reported in some patients, and to which any emerging finding could be added to avoid missing cases. Although different therapeutic options have been used, either as single agents or in combinations, there is no standard therapy for GEKA and the disease still represents a therapeutic challenge.

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Eruptive Keratoacanthoma With an Internal Malignant Neoplasm

Cited by 30 publications

References 24 publications

Generalized eruptive keratoacanthoma with vitiligo followed by the development of prurigo nodularis: A case report and published work review

Generalized eruptive keratoacanthoma with vitiligo followed by the development of prurigo nodularis: A case report and published work review

Generalized Eruptive Keratoacanthoma of Grzybowski: Follow-Up of the Original Description and 50-Year Retrospect

Generalized eruptive keratoacanthoma: proposed diagnostic criteria and therapeutic evaluation

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