Eruptive keratoacanthomas associated with immunosuppressive therapy in a patient with systemic lupus erythematosus

Skin Cancers of the Hand and Upper Extremity

“…14 They can present as solitary lesions, multiple lesions (generalized eruptive keratoacanthomas of Gryzbowski), 15 familial syndromes (familial keratoacanthomas of the Ferguson-Smith), 10 within the context of genetic disorders (Muir-Torre syndrome), 16 or associated with immunosuppressive therapy. 17,18 They have also been noted as a postoperative complication around surgical sites for skin cancer excision. 19 Squamous cell carcinoma has an associated risk of metastatic risk, which reinforces the importance of early identification and treatment.…”

Multiple Sebaceous Adenomas and Extraocular Sebaceous Carcinoma in a Patient with Multiple Sclerosis: Case Report and Review of Literature

“…38,39 Keratoacanthomas have been reported in a patient with impaired cellular immunity and autoimmune hemolytic anemia 40 and in a patient with systemic lupus erythematosis who was on immunosuppressive medications. 41 One MTS patient with alpha 1 antitrypsin de®ciency and necrotizing vasculitis developed multiple sebaceous adenomas and keratoacanthomas during immunosuppressive therapy for necrotizing vasculitis. 42 Many patients with MTS had underlying hematological malignancies and impaired immunity: 6 non-Hodgkin's lymphoma, 4 chronic lymphocytic leukemia, and 4 Hodgkin's disease (our unpublished data).…”

The genetics of cutaneous squamous cell carcinogenesis

“…Other risk factors include immunosuppression, skin trauma (e.g. surgical procedures, chemical peeling, dermabrasion, cryotherapy, photodynamic therapy or irritation after application of tar and imiquimod), and treatment with BRAF inhibitors and Hedgehog pathway inhibitors [13,14]. Clinically, it may present as a solitary lesion or as multiple lesions (Ferguson-Smith type) [14,15].…”