2009
DOI: 10.1016/j.jaad.2009.01.037
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Eruptive postoperative squamous cell carcinomas exhibiting a pathergy-like reaction around surgical wound sites

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Cited by 13 publications
(12 citation statements)
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“…2 These areas of normal-appearing epithelium may evolve into carcinoma given the stimulus of trauma and subsequent cytokine and growth factor release, high mitotic activity, and rapid proliferation associated with the epidermal healing process. With respect to the skin, it is postulated that clonal expansion of genotypically altered yet phenotypically and histologically normal keratinocytes will give rise to sheets of mutagenically altered epithelium.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…2 These areas of normal-appearing epithelium may evolve into carcinoma given the stimulus of trauma and subsequent cytokine and growth factor release, high mitotic activity, and rapid proliferation associated with the epidermal healing process. With respect to the skin, it is postulated that clonal expansion of genotypically altered yet phenotypically and histologically normal keratinocytes will give rise to sheets of mutagenically altered epithelium.…”
Section: Discussionmentioning
confidence: 99%
“…Such areas of altered epithelium have been detected at sizes greater than 7 cm in diameter within the mucosa of the head and neck. 2 These areas of normal-appearing epithelium may evolve into carcinoma given the stimulus of trauma and subsequent cytokine and growth factor release, high mitotic activity, and rapid proliferation associated with the epidermal healing process. Conceptually, this may explain why SCCs and KAs arise at sites of trauma.…”
Section: Discussionmentioning
confidence: 99%
“…The dermatopathology findings were not consistent with keratoacanthomas. The aetiology of these eruptive CSCCs was unclear but was probably related to a combination of field cancerization because of her history of extensive phototherapy [narrowband ultraviolet (UV)B and psoralen UVA] and her treatment with etanercept and methotrexate for her psoriasis …”
Section: Reportmentioning
confidence: 99%
“…The aetiology of these eruptive CSCCs was unclear but was probably related to a combination of field cancerization because of her history of extensive phototherapy [narrowband ultraviolet (UV)B and psoralen UVA] and her treatment with etanercept and methotrexate for her psoriasis. 1 The patient's age, her poorly controlled psoriasis and the presence of multiple tumours below the knee and recent cellulitis in the same leg increased the likelihood of healing complications and precluded surgical treatment. The patient had a strong preference against extensive surgical procedures.…”
Section: Reportmentioning
confidence: 99%
“…The amount of percutaneous absorption depends on many factors, for example the molecular structure/potency of the TCS. 1 We examined the effect of potent TCSs on adrenal gland cortisol production in 57 patients (mean age, 39 years; 43.9% men) with severe atopic dermatitis (AD) during and after treatment in hospital. On the first day of admission (day 1), patients were treated with 20 to 30 g of TCSs twice daily (n ¼ 31; class 1, 0.05% clobetasol propionate; and n ¼ 26; class 3, 0.1% betamethasone valerate).…”
Section: Research Lettermentioning
confidence: 99%