Eruptive Pseudoangiomatosis and Parvovirus: Exclusive Findings in Clinical Manifestation from a Report of Four Cases

Abstract

Introduction: Eruptive pseudoangiomatosis (EP) is a rare type of cutaneous exanthema characterized by red angioma-like papules. An association of EP with viral infection has been reported. We herein describe four pediatric patients who showed a new variant of EP-associated rash with atypical clinical features and positivity for parvovirus B19 infection. Case Report: Pediatric patients showed a new variant of EP-associated rash with atypical clinical features and positivity for parvovirus B19 infection by dermoscopy and reflectance confocal microscopy. The papules were localized to the face and characteristic perilesional halo was absent. In all patients, serology revealed evidence of active infection by parvovirus B19. Discussion: Few cases of a facial pseudoangiomatous rash that is related to parvovirus B19 infection and lacks the typical anemic halo have been reported in the literature. Conclusion: These cases provide new data on the clinical spectrum of EP and its association with parvovirus.