Eruptive Syringoma of the Penis. A Report of 2 Cases and a Review of the Literature

Abstract

Syringoma exclusively located to the penis is an extraordinary rare dermatological condition, and only 6 patients with syringoma exclusively located to the penis have been published previously. Light microscopical examination of routine hematoxylin and eosin-stained sections from punch biopsies with adequate depth from 2 patients was performed. Classical syringoma was diagnosed. The lesions occurred in an eruptive fashion in both patients on the dorsal and lateral aspects of the penis shaft. There was a variation in clinical appearances ranging from yellow-white papules, a few millimeter in size to, in one of the patients, formation of several slightly elevated plaques, 10 mm in size, with a brownish-red color. We describe clinicopathological features of 2 patients with syringoma exclusively located to the penis. These are compared with all the previously published cases. Clinical and histopathological differential diagnoses are discussed, and a literature review is presented.

Eruptive syringomas in the groin

“…On histologic examination, syringomas are easily recognizable by the presence of comma-or tadpole tail-shaped sweat ducts in the dermis. 2 Even though syringoma lesions are benign, they may be cosmetically distressing for patients. Treatment options, mostly based on small case series and case reports, include surgical excision, electrodessication and curettage, chemical peels, cryosurgery and laser therapy.…”

“…1 Rarely, syringomas can occur in extraocular sites, including the neck, axilla, breasts, lower abdomen, thighs and groin. 2 The risk factors for syringomas are unknown. Some investigators have suggested that syringomas may be caused by hormonal factors 3 or may be a reactive response to friction.…”

“…1,2 Given the benign nature of this condition, our patient declined cosmetic treatment and is being followed in our solid-organ transplant clinic for signs of any other skin malignancies or infection.…”

Eruptive Penile Syringomas Spreading to the Pubic Area and Lower Abdomen

“…An exact pathogenesis of syringoma is still unknown, but the neoplastic process, reactive hyperplasia, an association with hormonal factors is considered to be an etiologic factor2,3. Eruptive syringomas consist of the successive development of multiple papules in a limited area were thought to be a reactive process4.…”

“…The differential diagnosis of penile syringomas includes genital warts, lichen planus, bowenoid papulosis, angiokeratoma, angiofibroma, granuloma annulare, lichen nitidus, sarcoidosis, pearly penile papules, calcinosis cutis, and so on3.…”