Eruptive vascular tumors associated with chronic graft-versus-host disease

Lichen sclerosus and eosinophilic fasciitis as manifestations of chronic graft-versus-host disease: Expanding the sclerodermoid spectrum

“…Our patients demonstrated several additional cutaneous findings that have been previously observed in association with chronic GVHD, including ulcers, scarring alopecia, poikiloderma, nodular fibromas, angiomas, and photosensitive eruptions mimicking subacute cutaneous lupus erythematosus. 3,4,10,11,15,[40][41][42][43] Although xerosis and ichthyosiform changes are often seen in recipients of hematopoietic stem cell transplants, 40,44 the distinctive pattern of eczema craquelé involving the posterior axillary folds exhibited by 4 of our patients has not been previously described. This finding may be related to the sweat gland destruction that is often noted in biopsy specimens from patients with chronic GVHD.…”

Sclerodermatous Graft-vs-Host Disease

“…5 Since then, it has been infrequently described, 2 although results of ultrastructural studies showed dilated dermal capillaries. 30 Vascular tumors have been described in patients with ScGVHD, 34 but anetoderma has not been reported as a late complication of ScGVHD.…”

Graft-versus-host disease

“…Benign vascular tumors can develop on severely sclerotic skin [41][42][43] (Fig 4) and may require a biopsy specimen to rule out malignancy. Epidermodysplasia verucciformis (EV)elike lesions associated with human papillomavirus types 8 and 20 have been reported in the setting of GVHD and are linked to other EV-related haplotypes.…”