Eruptive Xanthomas

Koh, Xuan Qi; Chandran, Nisha Suyien

doi:10.1016/j.jpeds.2018.04.053

Cited by 3 publications

(2 citation statements)

References 3 publications

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“…xantoma plantar. El xantelasma es el subtipo más común, mientras que las otras variantes son raras 5 .…”

Section: Sus Variantes Clínicas Cutáneas Incluyen Xantomas Eruptivos Xantomas Tuberosos Xantomas Tendinosos Verruciformes Y Xantomas Planunclassified

Xantomas eruptivos como manifestación de dislipidemia

Lucas¹,

Masson-Pinto²,

Talledo-Mera³

et al. 2021

MCUT

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Los xantomas eruptivos son lesiones benignas raras que se presentan en la edad adulta, por lo general como una manifestación de un trastorno sistémico y en menor frecuencia como manifestación aislada. Se presenta el caso clínico de una paciente femenina de 31 años con antecedente de dislipidemia mixta que es derivada al servicio de dermatología por erupción súbita de pápulas amarillentas de 2 a 4 mm en superficies extensoras de miembros superiores, espalda baja, glúteos y palmas. Los hallazgos clínicos e histopatológicos confirmaron el diagnóstico de xantomas eruptivos.

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“…xantoma plantar. El xantelasma es el subtipo más común, mientras que las otras variantes son raras 5 .…”

Section: Sus Variantes Clínicas Cutáneas Incluyen Xantomas Eruptivos Xantomas Tuberosos Xantomas Tendinosos Verruciformes Y Xantomas Planunclassified

Xantomas eruptivos como manifestación de dislipidemia

Lucas¹,

Masson-Pinto²,

Talledo-Mera³

et al. 2021

MCUT

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“…14 If uncontrolled, childhood dyslipi-demia correlates with a higher risk of atherosclerosis and cardiovascular problems in adulthood. 15 Determining xanthoma etiology is imperative, as longterm sequelae can result from inadequate management of underlying disease. Appropriate diagnostic workup of eruptive xanthomas can unmask underlying hypertriglyceridemia, which carries an attributable increase of mortality from multiple causes.…”

Section: Case Reportmentioning

confidence: 99%

Eruptive xanthomas: a warning sign of future hyperlipidemia complications

et al. 2020

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<p>Eruptive xanthomas are localized lipid deposits in the skin or subcutaneous tissue that are associated with both primary and secondary hyperlipidemia. Typical presentation manifests as small yellow papules on the buttocks or extensor surfaces. Xanthomas can be diagnosed clinically with an extensive history and physical examination, however, can be confirmed via biopsy and histological findings. It is essential to identify the underlying cause of the skin lesions and take appropriate measures to prevent future hyperlipidemia-induced consequences. Here we report a 42-year-old female with eruptive xanthomas on her trunk and extremities. Previous visits to the primary care provider and emergency department resulted in diagnoses of viral exanthems. The consulted dermatologist ordered laboratory tests remarkable for extreme hypertriglyceridemia, hypercholesterolemia, and hyperglycemia. Lifestyle modification in conjunction with cholesterol and triglyceride lowering medications led to the resolution of abnormal laboratory findings and remission of eruptive xanthoma lesions.</p>

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Analysis of the characteristics of reflectance confocal microscopy images of xanthogranuloma and xanthoma

Sun,

Wang

2024

Int J Dermatology

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BackgroundBoth xanthogranuloma and xanthoma clinically manifest as yellowish skin lesions. Historically, the gold standard for diagnosis was skin histopathological examination. Currently, the advent of reflectance confocal microscopy (RCM) offers additional diagnostic support for these diseases by revealing their microscopic features, thereby enhancing the theoretical foundation for diagnosis.ObjectiveThis study aimed to elucidate the distinctive characteristics of RCM images in xanthogranuloma and xanthoma, assess their diagnostic value, and investigate the relationship between RCM and histopathological features, ultimately boosting diagnostic accuracy.MethodsRCM and histopathological examinations were conducted on 13 patients with xanthogranuloma and 12 with xanthoma, recruited from our Dermatology Clinic between August 2022 and November 2023. The study involved analyzing RCM image features and correlating them with histopathological findings.ResultsThe RCM images of 13 xanthogranuloma and 12 xanthoma cases showed similar features. Xanthogranuloma predominantly exhibited epidermal atrophy and thinning in 6 cases (46.15%). Additionally, in 69.23% of cases, scattered small mononuclear inflammatory cells were infiltrated in the superficial and middle dermis layers. Medium to high refractive cells, predominantly vacuolated and resembling foam, were observed in 61.54% of cases. All cases demonstrated high refractive cells with distinct target‐shaped, disc‐shaped, horseshoe‐like, and flower‐ring structures. Concordance rates with histopathological examinations were 69.23, 92.31, 92.31, and 100%, respectively. Regarding xanthoma, epidermal atrophy and thinning occurred in two cases (16.67%), and mononuclear inflammatory cell infiltration was observed in 25% of cases. High refractive cells with the previously mentioned shapes were present in 100% of cases, though only 16.67% displayed these characteristics exclusively. The concordance rates were 66.67, 91.67, 100, and 91.67%, respectively.ConclusionRCM imaging of xanthogranuloma and xanthoma presents distinctive, highly consistent features with their histopathology, offering valuable insights for clinicians in diagnosing and differentiating these conditions.

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Eruptive Xanthomas

Cited by 3 publications

References 3 publications

Xantomas eruptivos como manifestación de dislipidemia

Xantomas eruptivos como manifestación de dislipidemia

Eruptive xanthomas: a warning sign of future hyperlipidemia complications

Analysis of the characteristics of reflectance confocal microscopy images of xanthogranuloma and xanthoma

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