Erysenegalenseins H and I: Two New Isoflavones fromErythrina senegalensis¹

Abstract

In addition to the known Compounds senegalensin, lupinifolin, erythrisenegalone, and auriculatin, two new isoflavones named erysenegalensein H and erysenegalensein I were isolated from the dichloromethane extract of the stem bark of ERYTHRINA SENEGALENSIS DC. On the basis of spectroscopic methods their structures were elucidated as 5,2',4'-trihydroxy-8-(gamma,gamma-dimethylallyl)-2''-hydroxyisopropyldihydrofurano[4'',5'':6,7]-isoflavone and 5,2',4'-trihydroxy-8-(gamma,gamma-dimethylallyl)-3''-hydroxy-2'',2''-dimethyldihydropyrano [5'',6'':6,7]-isoflavone, respectively.

Prenylated flavanone derivatives isolated from Erythrina addisoniae are potent inducers of apoptotic cell death

“…In comparison to the regular isoprenyl side chain the methylene protons were no longer represented by one signal (δ 3.04 and 2.75) indicating a stereochemical effect, which was reported to be characteristic for a 3,3-dimethyloxiranylmethyl side chain. [14][15][16][17] Therefore, compound 1 could be identified as 3'-(2'',3''-epoxy-3''-methylbut-3''-enyl)licoflavanone by 1D and 2D NMR spectra. The structure was additionally confirmed by its mass spectra.…”

Systematic Review of Potential Anticancerous Activities of Erythrina senegalensis DC (Fabaceae)

“…Further studies on the other erysenegalenseins, as well as mechanistic studies, are thus needed to better identify the specific potential of these secondary metabolites to combat cancers. The fact that for now they have been isolated solely in E. senegalensis and the relatively low yield of the current extraction methods (from 0.12 mg/Kg of dried plant material to 67 mg/Kg [ 10 , 11 , 16 , 17 , 18 , 22 ]) may impede their evaluation as potential anticancer agents.…”

The chemistry and biological activities of natural products from Northern African plant families: from Ebenaceae to Solanaceae

“…The bark of Erythrina abyssinica (Leguminosae) has been used to cure cough, skin diseases, ulcers, abdominal pain, liver inammation, colic, trachoma and elephantiasis; the owers have been used for the treatment of dysentery and as an abortifacient; the leaves are used for the treatment of peptic ulcers, arthralgia and diarrhea; the roots are being used in preparing remedies for epilepsy, malaria and syphilis, while the fruit is used to cure asthma. 45 The bioassay-guided fractionation of the alkaloidal fraction of the seeds of E. abyssinica yielded erythraline (39), erysodine (40), erysotrine (41), 8-oxoerythraline (42), and 11-methoxyerysodine (43) on purication, Fig. 3.…”

“…30 Meanwhile, compounds 32 and 38 were isolated from the Cameroonian species. [42][43][44] Compounds 35 and 36 were evaluated for anticancer activity. The IC 50 values for compound 35 were less 50 mM against 43 cell lines with maximum cytotoxicity against colon cancer cell line HCC2998 (IC 50 ¼ 20 mM), while the IC 50 values were higher than 50 mM in all the ve tested leukemia lines.…”