Erysipelas of the right arm due to Bordetella trematum: a case report

Lacasse, Marion; Inyambo, K.; Lemaignen, Adrien; Mennecart, M.; Gensburger, Samuel; Valentin, Anne-Sophie; Bernard, Louis; Fougère, Bertrand

doi:10.1186/s13256-021-02896-1

Cited by 5 publications

(4 citation statements)

References 15 publications

(25 reference statements)

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“…The virulence string and clonal lineage of the other HLGR-GBS serotypes identified in this study are in line with findings from previous studies, confirming the already observed specific association between serotype, pili, alpha-like proteins, and clonal complexes [41][42][43][44][45][46][47].…”

Section: Discussionsupporting

confidence: 92%

Emergence of High-Level Gentamicin Resistance in Streptococcus agalactiae Hypervirulent Serotype IV ST1010 (CC452) Strains by Acquisition of a Novel Integrative and Conjugative Element

Creti,

Imperi,

Khan

et al. 2024

Antibiotics

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Streptococcus agalactiae (group B streptococci, GBS) is responsible for severe infections in both neonates and adults. Currently, empiric antimicrobial therapy for sepsis and meningitis is the combined use of penicillin and gentamicin due to the enhanced bactericidal activity. However, high-level gentamicin resistance (HLGR) abrogates the synergism. The rate of HLGR was investigated within a dataset of 433 GBS strains collected from cases of invasive disease in both adults and neonates as well as from pregnant carriers. GBS isolates (n = 20, 4.6%) presented with HLGR (gentamicin MIC breakpoint >1024 mg/L) that was differently diffused between strains from adults or neonates (5.2% vs. 2.8%). Notably, 70% of HLGR GBS strains (14 isolates) were serotype IV. Serotype IV HLGR-GBS isolates were susceptible to all antibiotics tested, exhibited the alpha-C/HvgA/PI-2b virulence string, and belonged to sequence type 1010 (clonal complex (CC) 452). The mobile element that harbored the HLGR aac(6′)-aph(2)″ gene is a novel integrative and conjugative element (ICE) about 45 kb long, derived from GBS 515 ICE tRNALys. The clonal expansion of this HLGR hypervirulent serotype IV GBS CC452 sublineage may pose a threat to the management of infections caused by this strain type.

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Section: Discussionsupporting

confidence: 92%

Emergence of High-Level Gentamicin Resistance in Streptococcus agalactiae Hypervirulent Serotype IV ST1010 (CC452) Strains by Acquisition of a Novel Integrative and Conjugative Element

Creti,

Imperi,

Khan

et al. 2024

Antibiotics

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“…Two cases of bacteraemia reported by Majewski et al [12] and Lacasse et al [13] had originated from infected skin and soft tissue sites, but resulted in very different clinical outcomes. Majewski et al described a fatal case from a rapidly progressive deep tissue Since 2015, there has been a cumulative number of B. trematum bacteraemia cases reported (Table 2).…”

Section: Discussionmentioning

confidence: 99%

“…[12] and Lacasse et al . [13] had originated from infected skin and soft tissue sites, but resulted in very different clinical outcomes. Majewski et al .…”

Section: Discussionmentioning

confidence: 99%

Bordetella trematum bacteraemia secondary to an empyema in an immunocompromised host: A case report and review of the literature

Wong

Calungsud

2023

Access Microbiology

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Introduction. Bordetella trematum infection remains uncommon. More cases of bacteraemia are reported in recent years with the primary infection largely originating from skin and soft tissue sites. Yet, our understanding of its virulence, antibiotic susceptibility profile and treatment is still limited. Case presentation. We report the first case of B. trematum bacteraemia from a left-sided empyema. An 87-year-old female patient with a past medical history of ischaemic heart disease, diabetes mellitus complicated by nephropathy and locally advanced left breast adenocarcinoma presented with fever, productive cough and shortness of breath. The B. trematum isolates from blood and pleural fluid were identified by MALDI-TOF and 16S rRNA sequencing. Ceftriaxone and azithromycin commenced empirically on admission were switched to piperacillin-tazobactam after 2 days due to lack of clinical improvement. Despite a pleurocentesis and 1 week of piperacillin-tazobactam with microbiological clearance in blood, the patient continued to deteriorate. Decision to withdraw treatment was made in view of the patient’s prognosis, and the patient succumbed on the fourteenth day of admission. The isolate was susceptible to piperacillin-tazobactam, imipenem and meropenem but had reduced susceptibility or was non-susceptible to cefuroxime, cefotaxime, ceftazidime, cefepime, the aminoglycosides and fluoroquinolones. Conclusion. Invasive B. trematum infection is associated with significant mortality. Consensus for antibiotic treatment remains unclear, with limited susceptibility data to support specific antibiotic use. We expect more clinical cases will surface with improved microbial identification systems, as well as enhanced clinical awareness. Standardized and more robust susceptibility work are needed to provide clear recommendations and establish consensus in treating invasive infections.

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“…B. trematum has been previously delineated as a unique bacterial species after a polyphasic investigation of ten isolates, including six isolates recovered from open wounds in patients, most of whom were European in origin [31]. B. trematum was further isolated in thirteen patients presenting with chronic cutaneous ulcers sometimes extending to underlying tissues and bones, and most patients originated from European countries [32][33][34][35][36][37], the United States [38], Brazil [39], Argentina [40] and Japan [41]. However, B. trematum has never been previously reported as a co-pathogen with M. ulcerans.…”

Section: Discussionmentioning

confidence: 99%

Mycobacterium ulcerans-Bordetella trematum chronic tropical cutaneous ulcer: A four-case series, Côte d’Ivoire

Tchan,

Kakou-Ngazoa,

Dizoe

et al. 2023

PLoS Negl Trop Dis

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Background Chronic tropical cutaneous ulcers remain a neglected medical condition in West Africa, particularly Buruli ulcer, which is caused by mycolactone cytotoxin-secreting Mycobacterium ulcerans (M. ulcerans). Medical management of this highly debilitating and necrotising skin infection may be modified by colonisation and co-infection of the ulcer by opportunistic and pathogenic microorganisms, which considerably delays and increases the cost of treatment. Methodology/principal finding We diagnosed chronic tropical cutaneous ulcers in nine patients in Côte d’Ivoire using M. ulcerans-specific PCRs and culturomics. This revealed M. ulcerans in 7/9 ulcer swabs and 5/9 control swabs as well as an additional 122 bacterial species, 32 of which were specific to ulcers, 61 specifics to the controls, and 29 which were shared, adding 40 bacterial species to those previously reported. Whole genome sequencing of four Bordetella trematum (B. trematum) isolates in four Buruli ulcer swabs and no controls indicated cytolethal distending toxins, as confirmed by cytotoxic assay. Conclusions/significance In four cases of Buruli ulcer in Côte d’Ivoire, B. trematum was a co-pathogen which was resistant to rifampicin and clarithromycin, unmatching M. ulcerans antibiotic susceptibility profile and counteracting the current treatment of Buruli ulcer in West Africa and Australia. Thus, we report here chronic mixed M. ulcerans-B. trematum chronic tropical ulcer as a specific form of Buruli ulcer in West Africa.

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Erysipelas of the right arm due to Bordetella trematum: a case report

Cited by 5 publications

References 15 publications

Emergence of High-Level Gentamicin Resistance in Streptococcus agalactiae Hypervirulent Serotype IV ST1010 (CC452) Strains by Acquisition of a Novel Integrative and Conjugative Element

Emergence of High-Level Gentamicin Resistance in Streptococcus agalactiae Hypervirulent Serotype IV ST1010 (CC452) Strains by Acquisition of a Novel Integrative and Conjugative Element

Bordetella trematum bacteraemia secondary to an empyema in an immunocompromised host: A case report and review of the literature

Mycobacterium ulcerans-Bordetella trematum chronic tropical cutaneous ulcer: A four-case series, Côte d’Ivoire

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