Erythema and bullae on the face and hands of a farm worker

Chen, O; Partarrieu-Mejías, Felipe; Alarcón-Cabrera, Rosario

doi:10.1111/ced.13639

Cited by 2 publications

(4 citation statements)

References 6 publications

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“…Bullous SS is an uncommon variant of SS that can present as flaccid or tense blisters on the acral surfaces, face, extremities, and trunk. On microscopic examination, separation of the dermal-epidermal junction can be appreciated [34][35][36]. The exact incidence of bullous SS is unknown, although up to 30% of patients with SS may present with bullae [7].…”

Section: Bullous Sweet Syndromementioning

confidence: 99%

“…Like classical SS, bullous SS can occur in patients with non-contributory past medical history, or it can also present in patients with chronic disease. Recently, a case of bullous SS without any underlying disease has been presented [34]; bullous SS has also been reported in the setting of acute myeloid leukemia (AML) and active [35] and inactive [36] ulcerative colitis. A case of bullous SS in a 10-year-old girl with a previous upper respiratory tract infection has also been described [37].…”

Section: Bullous Sweet Syndromementioning

confidence: 99%

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New Practical Aspects of Sweet Syndrome

et al. 2022

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Sweet syndrome (SS), or acute febrile neutrophilic dermatosis, is an inflammatory, non-infectious skin reaction characterized clinically by tender, erythematous papules/plaques/pustules/nodules commonly appearing on the upper limbs, trunk, and head and neck; histologically, SS is characterized by dense neutrophilic infiltrate in the dermis. SS is accompanied by fever; an elevation of inflammatory markers (e.g., erythrocyte sedimentation rate, C reactive protein) in serum may also be observed. Although most cases of SS are idiopathic, SS also occurs in the setting of malignancy or following administration of an associated drug. SS has also been reported in association with pregnancy and a burgeoning list of infectious (most commonly upper respiratory tract infections) and inflammatory diseases; likewise, the litany of possible iatrogenic triggers has also grown. Over the past several years, a wider spectrum of SS presentation has been realized, with several reports highlighting novel clinical and histological variants. Corticosteroids continue to be efficacious first-line therapy for the majority of patients with SS, although novel steroid-sparing agents have been recently added to the therapeutic armamentarium against refractory SS. New mechanisms of SS induction have also been recognized, although the precise etiology of SS still remains elusive. Here, we catalogue the various clinical and histological presentations of SS, summarize recently reported disease associations and iatrogenic triggers, and review treatment options. We also attempt to frame the findings of this review in the context of established and emerging paradigms of SS pathogenesis.

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Section: Bullous Sweet Syndromementioning

confidence: 99%

Section: Bullous Sweet Syndromementioning

confidence: 99%

New Practical Aspects of Sweet Syndrome

et al. 2022

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“…The lesions at the time of initial evaluation for this study were erythematous or violaceous plaques (51%), papules (42%), or nodules (32%). Other less common lesions reported were vesicles and pustules [ 12 ], and these should be differentiated from drug-induced reactions caused by drugs used for the treatment [ 43 ]. The lesions were tender in 43% of patients and the swelling of the affected area was only reported in 16% of cases [ 12 ].…”

Section: Resultsmentioning

confidence: 99%

“…Other clinical variants include bullous Sweet syndrome—a rare subtype of SS that can present with blisters, flaccid or tense, on the face, acral surfaces, extremities, and torso. Upon microscopic examination, a dermal–epidermal disjunction can be observed [ 18 , 43 , 44 , 45 , 46 ].…”

Section: Resultsmentioning

confidence: 99%

Sweet Syndrome Associated with Myelodysplastic Syndrome—A Review of a Multidisciplinary Approach

Ferea

Mihai

Bălan

et al. 2023

Life

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Sweet syndrome (SS) is a rare disease described as a febrile neutrophilic dermatosis with acute onset, the pathogenesis of which has not yet been elucidated. The syndrome is characterized by the sudden onset of erythematous infiltrated papules or plaques located on the upper body and is associated with fever, leukocytosis and neutrophilia. The lesions show a dense dermal infiltration with mature neutrophils. The condition is responsive to systemic steroids. The central nervous system, bones, muscles, eyes, ears, mouth, heart, lung, liver, kidneys, intestines, and spleen may be affected by SS as extracutaneous manifestations. More and more cases have been found to be associated with malignancies, particularly myelodysplastic syndrome, and, less frequently, other hematologic malignancies or solid tumors. Approximately 21% of patients with SS have an associated malignancy and up to 80% of MASS cases are associated with hematological diseases, predominantly myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). Myelodysplastic syndrome is a clonal disease of the bone marrow characterized by inefficient hematopoiesis, dysplasia of the bone marrow and peripheral cytopenias. Affected patients have a high risk of leukemic transformation. After analyzing later studies and current practical aspects regarding MDS-related SS, we suggest an algorithm for evaluating these patients.

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Erythema and bullae on the face and hands of a farm worker

Abstract: Click https://www.wileyhealthlearning.com/ced.aspx for the corresponding questions to this CME article.

Cited by 2 publications

References 6 publications

New Practical Aspects of Sweet Syndrome

New Practical Aspects of Sweet Syndrome

Sweet Syndrome Associated with Myelodysplastic Syndrome—A Review of a Multidisciplinary Approach

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