Erythema as a Visual Surrogate Marker of Glucagonoma

Ochi, Nobuaki; Kawahara, Tatsuyuki; Yamane, Hiromichi; Takigawa, Nagio

doi:10.2169/internalmedicine.0100-17

Cited by 1 publication

(1 citation statement)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ochi et al (31) described the erythema as a 'visual surrogate marker' for glucagon producing pNET. In addition to the rash but less frequent papules associated with pruritus or follicular pustules are found (32).…”

Section: Glucagonoma-associated Skin Lesionsmentioning

confidence: 99%

Glucagonoma: From skin lesions to the neuroendocrine component (Review)

et al. 2020

View full text Add to dashboard Cite

Glucagonoma is a hormonally active rare pancreatic neuroendocrine tumour causing an excess of glucagon. This is a narrative review based on a multidisciplinary approach of the tumour. Typically associated dermatosis is necrolytic migratory erythema (NME) which is most frequently seen at disease onset. Insulin-dependent diabetes mellitus, depression, diarrhoea, deep vein thrombosis are also identified, as parts of so-called 'D' syndrome. Early diagnosis is life saving due to potential aggressive profile and high risk of liver metastasis. NME as paraneoplastic syndrome may be present for months and even years until adequate recognition and therapy; it is remitted after successful pancreatic surgery. Thus the level of practitioners' awareness is essential. If surgery is not curative, debulking techniques may improve the clinical aspects and even the outcome in association with other procedures such as embolization of hepatic metastasis; ablation of radiofrequency type; medical therapy including chemotherapy, targeted therapy with mTOR inhibitors such as everolimus, PRRT (peptide receptor radiotherapy), and somatostatin analogues (including combinations of medical treatments). Increased awareness of the condition involves multidisciplinary practitioners.

show abstract

Section: Glucagonoma-associated Skin Lesionsmentioning

confidence: 99%