Erythema Chronicum Migrans Afzelius With Meningitis

Hellerström, S

doi:10.1097/00007611-195004000-00009

Cited by 47 publications

(20 citation statements)

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“…ADULT NEUROBORRELIOSIS Long before the characterization of Lyme disease, anecdotal reports 8,9 indicated that erythema migrans-associated meningitis was responsive to penicillin. The first treatment trial, 10 published in 1983, compared outcomes in 12 US patients with Lyme meningitis treated with high dose IV penicillin to those in a group of patients evaluated previously and treated only with prednisone.…”

mentioning

confidence: 99%

Practice Parameter: Treatment of nervous system Lyme disease (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology [RETIRED]

Halperin¹,

Shapiro²,

Logigian³

et al. 2007

Neurology

303

142

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Objective: To provide evidence-based recommendations on the treatment of nervous system Lyme disease and post-Lyme syndrome. Three questions were addressed: 1) Which antimicrobial agents are effective? 2) Are different regimens preferred for different manifestations of nervous system Lyme disease? 3) What duration of therapy is needed? Methods: The authors analyzed published studies ) using a structured review process to classify the evidence related to the questions posed. Results: The panel reviewed 353 abstracts which yielded 112 potentially relevant articles that were reviewed, from which 37 articles were identified that were included in the analysis. Conclusions:There are sufficient data to conclude that, in both adults and children, this nervous system infection responds well to penicillin, ceftriaxone, cefotaxime, and doxycycline (Level B recommendation). Although most studies have used parenteral regimens for neuroborreliosis, several European studies support use of oral doxycycline in adults with meningitis, cranial neuritis, and radiculitis (Level B), reserving parenteral regimens for patients with parenchymal CNS involvement, other severe neurologic symptomatology, or failure to respond to oral regimens. The number of children (Ն8 years of age) enrolled in rigorous studies of oral vs parenteral regimens has been smaller, making conclusions less statistically compelling. However, all available data indicate results are comparable to those observed in adults. In contrast, there is no compelling evidence that prolonged treatment with antibiotics has any beneficial effect in post-Lyme syndrome (Level A). NEUROLOGY 2007;69:91-102

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mentioning

confidence: 99%

Practice Parameter: Treatment of nervous system Lyme disease (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology [RETIRED]

Halperin¹,

Shapiro²,

Logigian³

et al. 2007

Neurology

303

142

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show abstract

“…Lennhoff's findings were not confirmed until 30 years later (Burgdorfer, 1984). But before that, in the 1950s, another Swedish dermatologist Hollström had showed that treatment with penicillin hasten the resolution of EM, which led to the use of penicillin for treatment of such symptoms in several European countries (Hellerström, 1951;Hollström, 1951).…”

Section: Short Review Of the Long History Of Lyme Borreliosismentioning

confidence: 99%

A STING from a Tick : Epidemiology, Ecology and Clinical Aspects of Lyme Borreliosis

Wilhelmsson¹

2014

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“…By the 1940s it was recognised that patients could have rheumatological symptoms, 10 and by the 1950s penicillin was known to provide effective treatment. 11 European work in the 1970s and 1980s ultimately led to the characterisation of the same group of causative spirochaetes. 4 Subsequent extensive microbiological work led to the identification of four strains of what has come to be known as B. burgdorferi sensu lato: B. burgdorferi sensu stricto, B. afzelii, B. garinii and, most recently, B. spielmanii.…”

Section: Aetiologymentioning

confidence: 99%

Nervous system Lyme disease

Halperin

2010

JRCPE

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Erythema Chronicum Migrans Afzelius With Meningitis

Cited by 47 publications

References 0 publications

Practice Parameter: Treatment of nervous system Lyme disease (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology [RETIRED]

Practice Parameter: Treatment of nervous system Lyme disease (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology [RETIRED]

A STING from a Tick : Epidemiology, Ecology and Clinical Aspects of Lyme Borreliosis

Nervous system Lyme disease

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