Erythema elevatum diutinum

Mançano, Vanessa de Sousa; Dinato, Sandra Lopes Mattos e; Almeida, Jurandy; Romiti, Ney

doi:10.1590/abd1806-4841.20187470

Cited by 12 publications

(30 citation statements)

References 4 publications

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“…3 If the lesions are resistant to dapsone therapy, other medications such as colchicine, corticosteroids and sulfapyridine can be initiated. 8 In this case, dapsone (50 mg/d) was sufficient to observe a significant improvement in fibrotic nodules. After starting the dapsone treatment, we recommend an efficacy evaluation follow-up after a minimum of 4 weeks of treatment.…”

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confidence: 69%

“…Histological findings of EED show neutrophilic vasculitis in the small vessels of the upper-mid dermis in earlier stages and fibrosis in the capillary walls in later stages. 8 Together with Sweet syndrome, pyoderma gangrenosum and subcorneal pustular dermatosis, EED is classified as neutrophilic dermatoses. 9 EED has no sex or race predilection.…”

mentioning

confidence: 99%

“…The onset of disease may vary; however, it is mostly seen between fifth and seventh decades. 8 EED usually follows a chronic course. Although spontaneous involution in 5 to 10 years has been reported, cases where lesions lasted for more than 25 years are also stated.…”

mentioning

confidence: 99%

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A rare presentation of erythema elevatum diutinum with annular lesions on the trunk

Yaycioglu

Vural

Dizioğlu³

2020

Dermatologic Therapy

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confidence: 69%

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confidence: 99%

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A rare presentation of erythema elevatum diutinum with annular lesions on the trunk

Yaycioglu

Vural

Dizioğlu³

2020

Dermatologic Therapy

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“…In the literature, hematologic and rheumatologic conditions have shown a strong association with EED as well . The most common differential diagnoses are: bacillary angiomatosis, dermatofibroma, Sweet syndrome, pyoderma gangrenosum, granuloma annulare, granuloma faciale, and Kaposi sarcoma …”

Section: Discussionmentioning

confidence: 99%

Erythema elevatum diutinum a rare and poorly understood cutaneous vasculitis: A single institution experience

et al. 2018

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Background Erythema elevatum diutinum (EED) is a rare vasculitis with variable clinical presentation which diagnosis can be challenging. Herein we want to describe the clinicopathological spectrum of findings in five cases of EED. Methods We retrospectively analyzed five cases in a single institution collected over a period of 27 years. The clinical history was collected and all the slides were examined to determine the histopathological characteristics of the lesions. Results The mean age of our patients is 56.6 years. Two of five patients were females and with lesions showing predilection for the upper‐extremities. The most common presentation was of an erythematous plaque on the extensor surfaces. Three patients had a history of neoplasm. All cases showed leukocytoclastic damage consistent with EED. Conclusion Our findings suggest that EED shows a heterogeneous clinical and pathological presentation, which can show an overlap with granulomatous dermatoses and mixed connective tissue diseases. Scalp lesions can occur and can mimic granulomatous dermatoses. The finding of EED in benign and malignant solid tumors in three of our patients begs the question whether there is an association between EED and such solid neoplasms.

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“…Although EEDs resemble keloids in their firmness upon palpation [4], their histopathologic characteristics are distinctive. In EED, significant fibrosis is evident with rich neutrophilic infiltrate in the walls of the microvasculature [5]. On the other hand, keloids demonstrate an invasive tumor-like growth in the papillary dermis with thickened but flattened epidermis, hyalinized collagen bundles in the dermis, and an obliterated papillary-reticular boundary [6].…”

Section: Introductionmentioning

confidence: 99%

A Case of Erythema Elevatum Diutinum (EED) Exhibiting A Keloid-Like Appearance

Zainab

Noda

Yabuno

et al. 2021

Dermatol Ther (Heidelb)

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Introduction: Most severe-appearing keloids tend to occur around joints because of the increased extensional stimulation of the scar in those areas. However, erythema elevatum diutinum (EED) appears more commonly on friction sites including extensor surfaces of the extremities and dorsal surfaces of joints. EEDs also presents as red-brown and elevated lesions. Case Presentation: In this report, we describe a 42-year-old female who presented with firm, sporadic, brown-colored raised nodules on her bilateral lower extremities. As the appearance of these nodules resembled keloids, resection of the affected area with subsequent radiation therapy was initiated. However, histopathologic examination performed after treatment revealed tuberous lesions in the dermis, increased wired collagen fibers, neutrophilic infiltrate with nuclear dust, and edematous endothelial cells in the small vessels. Consequently, the patient was later diagnosed with EED. Post-surgery, no recurrence or abnormal scars appeared. Discussion: Whereas clinical findings of EED are similar to that of keloids, the mechanisms of the two conditions differ considerably, leading to varying management strategies. EEDs can be misdiagnosed as keloids on several grounds; they can both appear morphologically similar, exhibit as stiff lesions, demonstrate chronic inflammation of the reticular dermis, and appear anywhere on the body. The only definitive method of differentiating between the two is through histopathologic examination. Conclusion: EED should be considered as one of the differential diagnoses for any patients presenting with keloid-like lesions on friction sites and biopsy should be performed prior to resection and radiotherapy.

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Erythema elevatum diutinum

Cited by 12 publications

References 4 publications

A rare presentation of erythema elevatum diutinum with annular lesions on the trunk

A rare presentation of erythema elevatum diutinum with annular lesions on the trunk

Erythema elevatum diutinum a rare and poorly understood cutaneous vasculitis: A single institution experience

A Case of Erythema Elevatum Diutinum (EED) Exhibiting A Keloid-Like Appearance

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