Erythema migrans nach Infektion durch Borrelia afzelii oder Borrelia garinii: Abhängigkeit des klinischen Erscheinungsbildes vom Geschlecht der Patienten

Bennet, Louise; Fraenkel, Carl-Johan; Garpmo, Ulf; Halling, Anders; Ingman, Mikael; Ornstein, Katharina; Stjernberg, Louise; Berglund, Johan

doi:10.1007/s00508-006-0659-1

Cited by 20 publications

(21 citation statements)

References 27 publications

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“…Borrelia garinii-associated macular EM is found in older patients, preferentially on the trunk, develops more rapidly and after a shorter incubation period, and is generally larger (Carlsson et al, 2003;Logar et al, 2004). These patients also more often have local and systemic symptoms and laboratory abnormalities (CRP, liver function tests) and are more frequently seropositive (Logar et al, 2004;Bennet et al, 2006). Thus B. garinii appears to induce a more virulent infection in European EM patients than does B. afzelii.…”

Section: Erythema Migrans In Europementioning

confidence: 94%

“…The patient's immune response is influenced by several factors, including age and sex, inducing varying clinical expressions of Lyme borreliosis in children and adults (M€ ullegger, 2004;Bennet et al, 2006). Differences in tissue microenvironment, such as the presence of stromal cells in varying body sites and their interaction with infiltrating immune cells, as well as modulation of the immune response by ultraviolet radiation in sun-exposed surfaces, may be additional factors that influence the course of infection (Brown et al, 1995;Douglas et al, 2002).…”

Section: Pathogenesismentioning

confidence: 99%

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Early Lyme Borreliosis

Sikand

Müllegger

2011

Lyme Borreliosis in Europe and North America

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Section: Erythema Migrans In Europementioning

confidence: 94%

Section: Pathogenesismentioning

confidence: 99%

Early Lyme Borreliosis

Sikand

Müllegger

2011

Lyme Borreliosis in Europe and North America

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“…7 Central clearing is less frequent in B. garinii infection, which is common in Europe. 8 Multiple lesions caused by haematogenous spread of Borrelia spp. occur in around a quarter of cases.…”

Section: Erythema Migransmentioning

confidence: 99%

Diagnosis, treatment and prevention of Lyme borreliosis

Cochrane¹,

Williams²

2011

Prescriber

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In Scotland, where Lyme borreliosis is notifiable, transmission is well recognised across the country with an incidence is 5.9 per 100 000 nationally, increasing to 43 per 100 000 in the Highlands. 4 Clinical manifestationsThe clinical manifestations of Lyme borreliosis are multiple and the natural histor y varied, but an understanding of the pathogenesis allows the disease to be viewed in three stages. In the first stage there is multiplication and local invasion of Borrelia spp. at the site of inoculation. In some people this is asymptomatic, while in others it causes erythema migrans, systemic symptoms (myalgia, headache, arthralgia, fatigue) or both.In the second stage there is dissemination and seeding of distant tissue manifesting commonly as nervous system disease or rarely as carditis. These early features of disseminated disease often overlap temporally with the local manifestations and these two stages have been termed 'early Lyme borreliosis'. As early Lyme borreliosis may manifest before seroconversion, negative acute serology does not rule out the diagnosis (see Table 1).The third stage, often termed 'late Lyme borreliosis', comprises later manifestations of dissemination occurring more than six months after infection, including arthritis, skin involvement and very rarely eye and late nervous system disease. It is fear of these late manifestations that is often of most con-50 Prescriber 5 March 2011 www.prescriber.co.uk antibody production synovial fluid or 95% in >99% (clean on discussion with reference laboratory biopsy for PCR previously lab) only untreated * These sensitivities and specificities were provided by Dr S O'Connel (HPA Lyme Diseases Reference Laboratory, Southampton) and are correct for that laboratory; the figures should not be used to interpret tests from unregulated laboratories. Sensitivity varies with duration of infection and infecting organism, with Borrelia burgdorferi sensu strictu triggering a more brisk response than Borrelia afzelii. PCR = polymerase chain reaction Prescribing in practice

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“…Multiple EM may also occur but are usually not the result of multiple tick bites; it rather indicates disseminated infection of the Borrelia spirochetes (Bratton et al, 2008). The diagnosis of EM is rather clinical than serological, patients with typical lesions are usually seronegative for Borrelia (Stanek et al, 1996;Strle, 1999 (Bennet et al, 2006;Cerar et al, 2008;Foldvari et al, 2005;Hulinska et al, 2009;Ornstein et al, 2001;Strle & Stanek, 2009). …”

Section: Erythema Migransmentioning

confidence: 99%

“…The second most common anatomical site of tick attachment recorded by the TBD STING-study participants was torso/dorsum (22%), followed by arms (18%), groin or genital (6%), and head or neck (4%). These proportions correspond arbitrarily to the anatomical distribution of EM that was found among LB patients (n = 118): legs (64%), torso/dorsum (25%), arms (10%) and genitalia (1.7%) (Bennet et al, 2006).…”

Section: Where On the Body Do Tick-bitten Persons Find Attached Ticks?mentioning

confidence: 99%

A STING from a Tick : Epidemiology, Ecology and Clinical Aspects of Lyme Borreliosis

Wilhelmsson¹

2014

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Erythema migrans nach Infektion durch Borrelia afzelii oder Borrelia garinii: Abhängigkeit des klinischen Erscheinungsbildes vom Geschlecht der Patienten

Cited by 20 publications

References 27 publications

Early Lyme Borreliosis

Early Lyme Borreliosis

Diagnosis, treatment and prevention of Lyme borreliosis

A STING from a Tick : Epidemiology, Ecology and Clinical Aspects of Lyme Borreliosis

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