Erythema multiforme

Ledesma, Glenn N.; McCormack, Patricia C.

doi:10.1016/0738-081x(86)90010-6

Cited by 9 publications

(14 citation statements)

References 24 publications

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“…25 The histopathological findings in EM are well recognized 1 . 3 –7 , 15 , 16 , 38 , 39 Our findings are consistent with those in the veterinary 3 , 4 , 8 , 15 , 16 , 38 and human 1 , 5 –7 , 39 literature. In dogs, direct immunofluorescence testing is usually negative (cases 7, 23, 26, 35, 37) 15 .…”

Section: Discussionsupporting

confidence: 91%

“…In humans, EM is most commonly associated with drug administration (over 110 different agents, notably sulphonamides, penicillins, barbiturates, and nonsteroidal anti‐inflammatory agents) and infections (over 35 different agents, especially herpes simplex virus and Mycoplasma pneumoniae ) 1 . 2 , 5 –7 There are numerous miscellaneous aetiologic associations, often documented by single case reports or review articles 1 . 2 , 5 –7 Examples of these presumptive trigger factors include various topical medications and chemicals, cosmetics, plants, neoplastic disorders, hyposensitization, foods, inflammatory bowel disease, and pregnancy 1 .…”

Section: Discussionmentioning

confidence: 99%

“… 2 , 5 –7 There are numerous miscellaneous aetiologic associations, often documented by single case reports or review articles 1 . 2 , 5 –7 Examples of these presumptive trigger factors include various topical medications and chemicals, cosmetics, plants, neoplastic disorders, hyposensitization, foods, inflammatory bowel disease, and pregnancy 1 . 2 , 5 , 7…”

Section: Discussionmentioning

confidence: 99%

“… 2 , 5 –7 Examples of these presumptive trigger factors include various topical medications and chemicals, cosmetics, plants, neoplastic disorders, hyposensitization, foods, inflammatory bowel disease, and pregnancy 1 . 2 , 5 , 7…”

Section: Discussionmentioning

confidence: 99%

“…Erythema multiforme (EM) is an acute reaction pattern of the skin and mucous membranes characterized by distinctive clinical and histopathological findings 1 –4 . It may be elicited by a wide array of trigger factors and the pathogenesis is incompletely understood 1 –7 . It is currently hypothesized that EM represents a host‐specific cell (T lymphocyte)‐mediated hypersensitivity reaction directed toward various antigens (drugs, infectious agents, etc.)…”

Section: Introductionmentioning

confidence: 99%

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Erythema multiforme in dogs and cats: literature review and case material from the Cornell University College of Veterinary Medicine (1988–96)

Scott

Miller

1999

Veterinary Dermatology

106

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A review of case material from the Cornell University College of Veterinary Medicine from 1988 to 1996 identified 20 dogs and one cat with definitive or presumed erythema multiforme. An additional 24 dogs and five cats with definitive or presumed erythema multiforme were found in the veterinary literature. Erythema multiforme accounted for only 0.40% and 0.11%, respectively, of all the canine and feline dermatology cases examined over a 9‐year period. German Shepherd dogs and Pembroke Welsh Corgis appeared predisposed. The condition was manifested as a vesiculobullous and/or ulcerative dermatosis in the majority of dogs and cats. In dogs, the most commonly affected body sites included the ventrum (especially axillae and groin), mucocutaneous junctions, oral cavity, pinnae, and footpads. Histopathological findings in cutaneous and mucocutaneous biopsy specimens were consistent with previously published criteria. In dogs, erythema multiforme occurred more frequently in patients receiving drug therapy. In cats, all cases of erythema multiforme were presumed to be drug related. Elimination of the associated trigger factor and supportive care usually resulted in resolution of the erythema multiforme within 1–2 weeks. Four dogs with severe idiopathic erythema multiforme were successfully managed with glucocorticoids or azathioprine.

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