Erythema Multiforme and Crohn's Disease of the Large Intestine

Brenner, S; Delany, Harry M.

doi:10.1016/s0016-5085(72)80157-4

Cited by 21 publications

(5 citation statements)

References 8 publications

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“…43,44 Oral tacrolimus therapy seems to be associated with short-and long-term benefits 45 and may represent a therapeutic option in CD when conventional therapies fail. Tables 1 and 2) Reactive (immune-related) lesions secondary to CD Pyoderma gangrenosum 155,156 Erythema nodosum 156 Erythema multiforme 157,158 Finger clubbing 159 Palmar erythema 6 Rosacea-like eruption 160 Pyoderma faciale 161 Epidermolysis bullosa acquisita 162 Secondary systemic amyloidosis 163 Vitiligo 95,164 Palmo-plantar pustulosis 165 Sweet's syndrome 166 Lesions from nutritional deficiencies Acrodermatitis enteropathica-like syndrome (acquired zinc deficiency) 167 Marasmic striae 6 Infliximab has been used with success for treatment of extra-intestinal manifestations of CD. [46][47][48] There are four successfully treated cases of MCD; [49][50][51][52] one of them uses a combination of infliximab with methotrexate.…”

Section: Treatmentmentioning

confidence: 99%

Metastatic Crohn's disease: a review

Παλαμάρας

El-Jabbour

Pietropaolo

et al. 2008

Acad Dermatol Venereol

108

123

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Metastatic Crohn's disease (MCD) indicates the presence of non-caseating granuloma of the skin at sites separated from the gastrointestinal tract by normal tissue and is the least common dermatologic manifestation of CD. In adults, MCD usually appears after the initial diagnosis of CD in 70% of cases, whereas in children, it appears at the same time as CD in almost half of the cases. The most frequent skin lesions in adults are nodules, plaques with or without ulceration on the extremities and ulcers on the genitals. In children, genital swelling with or without erythema is the most frequent presentation of MCD. Simultaneous presence of perianal CD affects more females (60%) and particularly children. Associated gastrointestinal symptoms are present in one third of the cases in adults and in half of the cases in children. Treatment is often unsatisfactory. Randomised controlled trials are lacking. Various chemotherapeutic agents have been used such as oral metronidazole, topical and/or oral steroids, azathioprine, cyclosporine, sulfasalazine, tetracyclines, topical or systemic tacrolimus, infliximab alone or with methotrexate, and surgical treatment with oral zinc sulphate. MCD represents another 'great imitator'. This reviews the most relevant characteristics of this disease, in order to increase awareness and to avoid delay in diagnosis and improve management of the whole CD complex.

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Section: Treatmentmentioning

confidence: 99%

Metastatic Crohn's disease: a review

Παλαμάρας

El-Jabbour

Pietropaolo

et al. 2008

Acad Dermatol Venereol

108

123

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“…The combination of positive anti-Saccharomyces cerevisiae antibodies and negative perinuclear ANCA, as seen in this patient, has a reported 96% positive predictive value for Crohn's disease, 8 (Table 1), [11][12][13] although one of these patients developed targetoid lesions after infliximab administration 11 Although HSV is the most likely trigger, given its overall prevalence in adolescent erythema multiforme, unique aspects of this case (continued activity despite compliance with valacyclovir, negative PCR, unusual presentation with prominent lip edema and bullae on the back) suggest a complex immunologic interplay between Crohn's, orofacial granulomatosis, and erythema multiforme. Erythema multiforme itself can occur as a true cytotoxic autoimmune type IV immune response to keratinocytes, best exemplified by the erythema multiforme-like reactions in Rowell's syndrome.…”

Section: Case Presentationmentioning

confidence: 58%

“…Although uncommon, erythema multiforme has been reported in association with IBD, although most of these cases occurred in patients with ulcerative colitis . A PubMed search of articles indexed for MEDLINE using the terms Crohn's, Crohn's disease, inflammatory bowel disease, and erythema multiforme revealed three isolated case reports of erythema multiforme in association with Crohn's disease (Table ), although one of these patients developed targetoid lesions after infliximab administration and one after sulfasalazine, perhaps suggesting medication‐induced erythema multiforme.…”

Section: Discussionmentioning

confidence: 99%

Orofacial granulomatosis and erythema multiforme in an adolescent with Crohn's disease

Georgesen

Huang

Avarbock

et al. 2018

Pediatric Dermatology

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The cutaneous manifestations of Crohn's disease are myriad. A 15-year-old girl presented with recurrent lip swelling and eventual development of diarrhea and targetoid macules on the palms, feet, and back. She was finally diagnosed with Crohn's disease in the setting of a clinical presentation and histopathology consistent with orofacial granulomatosis and erythema multiforme. We review the literature and summarize reported occurrences of these cutaneous diseases in children with Crohn's disease.

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“…Crohn's disease's histopathology is marked by inflammation, edema, granulomas, and giant cells. Many cutaneous conditions have been associated frequently and episodically with CD (Table 1) (4–23).…”

Section: Discussionmentioning

confidence: 99%

Crohn's Disease and Lichen Nitidus: A Case Report and Comparison of Common Histopathologic Features

Scheinfeld¹,

Teplitz²,

McClain³

2001

Inflammatory Bowel Diseases

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We describe a 54-year-old black woman with Crohn's disease, who developed lichen nitidus, the third report of a patient with both diseases. The rarity of these diseases individually and the histopathologic features in common imply that the two diseases are linked. Multinucleated giant cells, a common finding in the lesions of Crohn's disease, are less common in the lesions of lichen nitidus. The presence of multinucleated giant cells in lichen nitidus in all three case reports is distinctly unusual. The infiltrates of Crohn's disease and lichen nitidus contain CD-68-positive macrophages. As such, the subset of lichen nitidus with giant cells should be recognized as a cutaneous manifestation of Crohn's disease.

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Erythema Multiforme and Crohn's Disease of the Large Intestine

Cited by 21 publications

References 8 publications

Metastatic Crohn's disease: a review

Metastatic Crohn's disease: a review

Orofacial granulomatosis and erythema multiforme in an adolescent with Crohn's disease

Crohn's Disease and Lichen Nitidus: A Case Report and Comparison of Common Histopathologic Features

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