Erythema Multiforme from Metformin

Burger, David E; Goyal, Seema

doi:10.1345/aph.1e074

Cited by 22 publications

(4 citation statements)

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“…Cutaneous reactions to oral antidiabetic agents are rather rare. Allergic reactions, leukocytoclastic vasculitis, erythema multiforme and psoriasiform drug eruption have been described to the biguanide drug metformin 111–114 . Furthermore, pemphigus vulgaris and psoriasiform drug eruption have been reported to the sulfonylurea glibenclamide 115–117 .…”

Section: Skin Complications Due To Therapy Of Diabetesmentioning

confidence: 99%

“…Allergic reactions, leukocytoclastic vasculitis, erythema multiforme and psoriasiform drug eruption have been described to the biguanide drug metformin. [111][112][113][114] Furthermore, pemphigus vulgaris and psoriasiform drug eruption have been reported to the sulfonylurea glibenclamide. [115][116][117] It should be beared in mind that most of the sulfonylureas induce cutaneous photosensitivity.…”

Section: Cutaneous Reactions To Oral Antidiabetic Agentsmentioning

confidence: 99%

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Skin signs in diabetes mellitus

Behm

Schreml

Landthaler

et al. 2012

Acad Dermatol Venereol

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Diabetes mellitus is the most common endocrine disorder with continuously increasing prevalence. Blood vessels, nerves, eyes, kidneys and skin are affected, which causes both an enormous financial burden and a reduced quality of life of the affected patients. Long-standing diabetes may impair skin homeostasis resulting in skin manifestations in at least one third of all diabetics. The skin involvement may be the first presenting sign of diabetes, thus the respective skin signs should lead to diabetes focused diagnostic. Besides, the skin signs may be considered as a marker for the course of the disease or for the success of therapeutic interventions.

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Section: Skin Complications Due To Therapy Of Diabetesmentioning

confidence: 99%

Section: Cutaneous Reactions To Oral Antidiabetic Agentsmentioning

confidence: 99%

Skin signs in diabetes mellitus

Behm

Schreml

Landthaler

et al. 2012

Acad Dermatol Venereol

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“…It is commonly associated with gastrointestinal adverse effects, yet dermatologic reactions to metformin are uncommon and the literature detailing these events and their management is sparse [ 2 ]. Case reports of possible reactions to metformin include erythema multiforme, lichen planus, rosacea, and pseudoporphyria [ 3 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

Metformin-Induced Fixed-Drug Eruption Confirmed by Multiple Exposures

2016

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Patient: Female, 56Final Diagnosis: Fixed-drug eruptionSymptoms: —Medication: MetforminClinical Procedure: Discontinued metforminSpecialty: Family MedicineObjective:Unusual or unexpected effect of treatmentBackground:A fixed-drug eruption (FDE) is a reaction characterized by cutaneous lesions that appear due to exposure to a particular drug. Barbiturates, carbamazepine, sulfamethoxazole, and tetracyclines have all been associated with causation of FDEs. Although these drugs are more commonly associated with FDEs, any introduction of a medication has the potential to result in a FDE. Metformin, a commonly used medication to improve glycemic control, has been reported to cause dermatologic reactions in some case reports, but only a single previously documented case report discusses the potential of metformin-associated FDE.Case Report:We describe a 56-year-old woman who developed a FDE with multiple exposures to metformin. Upon each exposure, small, round, erythematic lesions developed on the palms of the hands and soles of the feet; these lesions resolved each time after discontinuation of metformin. According to the Naranjo scale, there is a definite association between metformin and FDE in this case (score of 8).Conclusions:This report contributes to the limited documented literature on metformin-induced FDE. Clinicians should be made aware of possible FDEs associated with this commonly used medication.

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“…[4] Alongwith this various vaccines( hepatitis B, [6] smallpox, [7] diphtheria-tetanus), [8] viruses (cytomegalovirus, [9,10] hepatitis C, [11] human immunodeficiency virus and varicella zoster virus) and newer medicines (bupropion [Wellbutrin], [12][13][14] candesartan cilexetil [Atacand], [15] adalimumab [Humira], [16] ciprofloxacin [Cipro], [17] rofecoxib [Vioxx; withdrawn from the United States market] and metformin [Glucophage] have been implicated in the pathogenesis of erythema multiforme. [18,19] The HSV infection may remain clinically silent where recurrent erythema multiforme is secondary to HSV-1 and HSV-2 reactivation. [20] A study was conducted on 63 patients suffering from erythema multiforme where HSV-DNA was detected by Section: Dentistry polymerase chain reaction in skin biopsy specimens in 60 percent of patients with clinically diagnosed recurrent herpes associated erythema multiforme and in 50 percent of patients suffering from recurrent idiopathic erythema multiforme which has been defined as erythema multiforme with no apparent clinical history of HSV infection or drug ingestion.…”

Section: Etiology and Pathogenesismentioning

confidence: 99%

Erythema Multiforme Etiopathogenesis and Treatment A Review Article

Awale¹,

Ranjan²,

Darad³

et al. 2018

AIMDR

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Background: Erythema multiforme is an acute inflammatory hypersensitivity reaction triggered by different infections and drugs characterised clinically by typical target or iris lesions. It is clinically classified into EM minor, EM major depending on the severity and serious complications like Steven Johnsons syndrome and Toxic Epidermal Necrolysis may be seen. Treatment involves identifying the triggering factor followed by corticosteroid and anitihistamines in mild cases and anitiviral therapy like prescribing acyclovir in herpes associated erythema multiforme.

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Erythema Multiforme from Metformin

Cited by 22 publications

References 0 publications

Skin signs in diabetes mellitus

Skin signs in diabetes mellitus

Metformin-Induced Fixed-Drug Eruption Confirmed by Multiple Exposures

Erythema Multiforme Etiopathogenesis and Treatment A Review Article

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