Erythema multiforme-like drug reaction with eosinophilia and systemic symptoms (DRESS)

Hoshina, Daichi; Furuya, Kazuhiko; Okita, I

doi:10.1111/ced.12541

Cited by 8 publications

(16 citation statements)

References 5 publications

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“…2,23 Occasionally, facial edema, mucosal involvement including cheilitis, erosions, pharyngeal or tonsil exanthema, and genital erythema were observed. 2,23 Occasionally, facial edema, mucosal involvement including cheilitis, erosions, pharyngeal or tonsil exanthema, and genital erythema were observed.…”

Section: Discussionmentioning

confidence: 99%

“…Vesicles/bullae, sterile pustules, purpuric lesions, or atypical targetoid plaques similar to erythema multiforme could also be detected. 2,23 Occasionally, facial edema, mucosal involvement including cheilitis, erosions, pharyngeal or tonsil exanthema, and genital erythema were observed. Pronounced facial edema is estimated to occur in approximately 25% of DRESS cases, 2 and accordingly, 28% of our patients had facial swelling.…”

Section: Discussionmentioning

confidence: 99%

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Clinical features of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a study of 25 patients in Korea

Lee

Hahm

et al. 2017

Int J Dermatology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical features of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a study of 25 patients in Korea

Lee

Hahm

et al. 2017

Int J Dermatology

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“…9 It is typically associated with exposure to aromatic anticonvulsants, sulfonamides, minocycline, dapsone, and allopurinol. 8 Temozolomide is rarely associated with DIHS and has been reported to occur 6 weeks after drug initiation. 10 Common clinical features include fever, rash, lymphadenopathy, hematologic abnormalities, and internal organ involvement.…”

Section: Discussionmentioning

confidence: 99%

“…A punch biopsy was not completed because the histopathological changes associated with DIHS are not well-established. 8 Given the onset of symptoms, temozolomide was determined to be the most likely culprit and was held at this time. The patient was started on a gradual steroid taper to be completed over the following 8 weeks.…”

Section: Case Presentationmentioning

confidence: 99%

Drug-induced hypersensitivity syndrome following temozolimide for glioblastoma multiforme and the role of desensitization therapy

Ambur

Khan

et al. 2021

J Oncol Pharm Pract

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Introduction Temozolomide is an oral alkylating agent used as first line treatment of glioblastoma multiforme (GBM). It has also been used in the treatment of certain solid tumors such as metastatic melanoma. Commonly reported adverse effects include nausea and vomiting, constipation, headache, fatigue and myelosuppression. Cutaneous hypersensitivity reactions are rare and include an urticarial hypersensitivity reaction, alopecia, and Stevens–Johnson syndrome. To our knowledge, there are minimal reports of temozolomide-induced DRESS syndrome. Case Report We present a 54-year-old man with glioblastoma multiforme who presented with a fever, diarrhea and progressively worsening rash 6 weeks after starting temozolomide. Management & Outcome The patient was diagnosed recurrent DRESS syndrome and restarted on a gradual prednisone taper with resolution over the following weeks. Unfortunately, the patient was unable to be followed long-term due to relocation to a different state. Discussion To our knowledge, there are minimal reports of temozolomide-induced DRESS syndrome. The diagnosis can be life-threatening, which makes management of patients with GBM and no alternative treatment option challenging. The use of de-sensitization therapy to temozolomide has been proposed for the management of severe adverse cutaneous reactions.

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“…The patient was discharged from the hospital on day 67 once symptoms were resolved. 10 Hoshina et al 11 reported a case of a 28-year-old female with schizophrenia who presented to the hospital with a 1-week history of fever, malaise, and skin eruptions. Skin biopsy revealed a perivascular infiltration with lymphocytes and eosinophilia.…”

Section: Carbamazepinementioning

confidence: 99%

Evaluation of Anticonvulsant-Induced Leukocytosis: A Review of Evidence for Carbamazepine, Lamotrigine, and Phenobarbital

Sutton,

Csurgo,

Reinert

2024

Journal of Pharmacy Technology

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Objective: The objective was to determine the incidence of leukocytosis associated with carbamazepine, lamotrigine, and phenobarbital. Data sources: A comprehensive literature review was conducted with the assistance of a medical reference librarian on PubMed, MEDLINE, Embase, and Google Scholar through June 2023 using the following search terminology: “leukocytosis/chemically induced”[MeSH Terms] AND (“Anticonvulsants”[MeSH Terms] OR (“Anticonvulsants”[Pharmacological Action] OR “Anticonvulsants”[MeSH Terms] OR “Anticonvulsants”[All Fields] OR “anticonvulsant”[All Fields] OR “anticonvulsion”[All Fields] OR “anticonvulsive”[All Fields] OR “anticonvulsives”[All Fields]) OR (“Anticonvulsants”[Pharmacological Action] OR “Anticonvulsants”[MeSH Terms] OR “Anticonvulsants”[All Fields] OR “antiepileptic”[All Fields] OR “antiepileptics”[All Fields])). Study selection and data extraction: Thirteen reports were included from 64 potential results of our literature review following the application of inclusion and exclusion criteria: 7 of the reports involved carbamazepine, 4 of the reports involved lamotrigine, and 2 of the reports involved phenobarbital. Data synthesis: Drug-induced leukocytosis is commonly a diagnosis of exclusion and is a phenomenon that has numerous ramifications to patients and clinicians at the bedside, including mandating a full infectious evaluation, the identification of confounding variables, and the eventual discontinuation of the offending agent. Despite several medications and medication classes possessing this adverse drug effect, an evaluation of the specific clinical presentation and management strategies for drug-induced leukocytosis associated with anticonvulsant medications has not been elucidated in the literature. Conclusions: Clinicians should be judicious when evaluating leukocytosis in patients on potentially precipitating medications, including carbamazepine, lamotrigine, and phenobarbital.

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Erythema multiforme-like drug reaction with eosinophilia and systemic symptoms (DRESS)

Cited by 8 publications

References 5 publications

Clinical features of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a study of 25 patients in Korea

Clinical features of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a study of 25 patients in Korea

Drug-induced hypersensitivity syndrome following temozolimide for glioblastoma multiforme and the role of desensitization therapy

Evaluation of Anticonvulsant-Induced Leukocytosis: A Review of Evidence for Carbamazepine, Lamotrigine, and Phenobarbital

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