Erythorbyl laurate as a potential food additive with multi-functionalities: Antibacterial activity and mode of action

Park, Kyung Min; Jo, Su-Kyung; Yu, Hyunjong; Park, Jun-Young; Choi, Soo Jung; Lee, Chang Joo; Chang, Pahn–Shick

doi:10.1016/j.foodcont.2017.11.008

Cited by 31 publications

(9 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has also been shown that erythorbyl laurate exerts both bacteriostatic and bactericidal effects on Gram-positive pathogens, including Staphylococcus aureus, Listeria monocytogenes, and Bacillus cereus, which might result from alterations in the permeability of the cytoplasmic membrane and bacterial cell wall rupture [19].…”

Section: Introductionmentioning

confidence: 99%

“…It is widely accepted that the primary target of antibacterial fatty acids is the bacterial cell membrane [5,17,19]. To be more specific, antibacterial fatty acids and their derivatives are incorporated into bacterial cell membranes, thus disrupting the selective permeability of the membranes and in turn exerting bacteriostatic and bactericidal effects on the cells.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hydrophilic and lipophilic characteristics of non-fatty acid moieties: significant factors affecting antibacterial activity of lauric acid esters

Park

Lee

et al. 2018

Food Sci Biotechnol

Self Cite

View full text Add to dashboard Cite

It has been proposed that the hydrophilic and/or lipophilic characteristics of fatty acid derivatives affect their antibacterial activities according to their ability to incorporate into the bacterial cell membrane. To verify this hypothesis, six kinds of lauric acid derivatives esterified with different non-fatty acid moieties were selected to confirm whether antibacterial activity from their precursor (i.e., lauric acid) is retained or lost. Three compounds, monolaurin, sucrose laurate, and erythorbyl laurate, exerted bacteriostatic and bactericidal effects against Gram-positive bacteria, while the others showed no inhibitory activity. Interestingly, the calculated log (octanol-water partition coefficient) values of monolaurin, sucrose laurate, and erythorbyl laurate were - 4.122, - 0.686, and 3.670, respectively, relatively lower than those of the other compounds without antibacterial activity. Moreover, the hydrophilic-lipophilic balance values of the three compounds with antibacterial activity were higher than those of the other compounds, corresponding to the log result.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hydrophilic and lipophilic characteristics of non-fatty acid moieties: significant factors affecting antibacterial activity of lauric acid esters

Park

Lee

et al. 2018

Food Sci Biotechnol

Self Cite

View full text Add to dashboard Cite

show abstract

“…In comparison, the MBCs of EL in the O/W emulsions against the Gramnegative bacteria E. coli and P. aeruginosa were both 2.00 mM ( Figure S3 in Supplementary Data). e previous study on the antibacterial activity of EL against bacteria found that Gram-negative bacteria were not susceptible to EL in the aqueous phase [7]. However, the result showed that EL in the O/W emulsion had antimicrobial activity against both Gram-positive and Gram-negative bacteria.…”

Section: Antimicrobial Activity Of El In O/w Emulsionmentioning

confidence: 92%

“…e minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of EL against these Gram-positive bacteria were determined, and the antibacterial mechanism was thought to be disruption of the bacterial cell membrane [7]. In addition, it was investigated EL exhibited more effective antioxidative activity than that of erythorbic acid in oil-in-water (O/W) emulsion system since its antioxidative moiety is located on the interface of droplets where lipid oxidation mostly occurs [8].…”

Section: Introductionmentioning

confidence: 99%

“…Fundamental investigation on antibacterial properties of EL with regard to antibacterial activity and mode of action was carried out in the previous study [7], but no study has been performed to bring detailed knowledge of antimicrobial properties of EL for the practical applications. erefore, the aim of this study is comprehensive evaluation of antimicrobial properties of EL for the practical applications in food and cosmetics.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antimicrobial Characterization of Erythorbyl Laurate for Practical Applications in Food and Cosmetics

Kim

Park

et al. 2020

Journal of Chemistry

Self Cite

View full text Add to dashboard Cite

In this study, antimicrobial spectrum of erythorbyl laurate (EL) against bacteria and fungi, leading to food-borne and infectious skin diseases, was evaluated for its practical applications in food and cosmetics. Furthermore, the influences of environmental factors including pH, oxidative stress, and dispersion medium on antimicrobial activity of EL were investigated. The three Gram-positive bacteria and the three molds were susceptible to 3.0 mM EL, while the yeast was susceptible to 6.0 mM EL. It was demonstrated EL retained antibacterial activity against Staphylococcus aureus after being oxidized while the antibacterial activity against the three Gram-positive bacteria including S. aureus, Bacillus cereus, and Listeria monocytogenes was significantly enhanced as decrease of pH from 7.0 to 5.0. Moreover, EL exhibited bactericidal effects against both Gram-positive and Gram-negative bacteria in an oil-in-water emulsion. Treatment of 5.0 mM EL for 4 h reduced 5.29 ± 0.24, 6.01 ± 0.18, 5.95 ± 0.13, and 6.24 ± 0.30 log CFU/mL against S. aureus, L. monocytogenes, Pseudomonas aeruginosa, and Escherichia coli, respectively. In a multipassage resistance selection study, it was observed minimum inhibitory concentrations of EL against S. aureus were not increased over 20 passages, indicating EL might not develop drug resistance of bacteria. This study suggests EL has a potential to be applied as the multifunctional additive in food and cosmetics.

show abstract

Antibacterial and in vitro antidementia effects of aronia (Aronia melanocarpa) leaf extracts

Kim

Shin

2020

Food Sci Biotechnol

View full text Add to dashboard Cite

Erythorbyl laurate as a potential food additive with multi-functionalities: Antibacterial activity and mode of action

Cited by 31 publications

References 27 publications

Hydrophilic and lipophilic characteristics of non-fatty acid moieties: significant factors affecting antibacterial activity of lauric acid esters

Hydrophilic and lipophilic characteristics of non-fatty acid moieties: significant factors affecting antibacterial activity of lauric acid esters

Antimicrobial Characterization of Erythorbyl Laurate for Practical Applications in Food and Cosmetics

Antibacterial and in vitro antidementia effects of aronia (Aronia melanocarpa) leaf extracts

Contact Info

Product

Resources

About