Erythroblastaemia in natalizumab-treated patients with multiple sclerosis

Reappraising the role of α5 integrin and the microenvironmental support in stress erythropoiesis

“…This view is consistent with a broad conclusion from the literature on a5 integrins in other cell types in which other integrins in the absence of a5b1 can substitute for Fn/matrix assembly partially or completely depending on the cell type [11,19−21]. However, in contrast to data on proliferative expansion of early erythroid precursor cells, which suffer when both a4 and a5 integrins are missing, for the BM erythroblast retention (in mice [5] and humans [22,23]) and terminal maturation of erythroid cells, only a4b1 integrin assumes a dominant role. A significant transient delay in erythroid stress response is seen when only a4 integrin is missing [4,5], as well as in all other models where a4 is combined with deficiencies of other integrins [4].…”

Performance evaluation of the automated nucleated red blood cell count of five commercial hematological analyzers

“…Moreover, the technology of modern HAs highly improved the sensitivity in detecting LoQ, the low level of NRBC in PB that can be determined with acceptable precision. This allowed to recognize a group of individuals, without increased erythropoiesis or a pathologic bone marrow process or an underlying pathologic condition, who have low‐level circulating NRBC with otherwise normal WBC morphology and parameters . These samples may represent a subset of normal population, but further studies are needed to assess and confirm this finding.…”