Erythroblastosis fetalis and its association with universal edema of the fetus, icterus gravis neonatorum and anemia of the newborn

“…4 The mystery behind many clinically observed scenarios of HDFN involving red cell haemolysis, ranging widely from severely hydropic stillborn foetuses to infants with mild or significant levels of jaundice and kernicterus were not realised completely until twentieth century. 6 In 1892, Ballantyne described a criteria for diagnosing HDFN in 1912, Diamond, Blackfan and Baty investigated the associated clinical features and in 1938 Hellman and Hertig first recognised the familial incidence of disease. 4 In 1938 Dr. Ruth of Women and Children Hospital, Chicago, who was a sufferer of Rh haemolytic disease, investigated and published a comprehensive analysis on Icterus Gravis Neonatorum.…”

Section: Discussionmentioning

confidence: 99%

Frequency of Antibodies in Haemolytic Disease of Foetus and Newborn

Vilambil¹,

Dharmadas²,

Usha³

et al. 2017

jemds

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BACKGROUNDHaemolytic disease of foetus and newborn (HDFN) is triggered by enhanced destruction of red blood cell due to immune-mediated destruction, intrinsic abnormalities, acquired aberrations, etc. Lifespan of infant's erythrocytes are shortened by the action of placentally transferred maternal antibodies in immune-mediated HDFN.The aim of this study was to identify the frequency of maternal antibodies in neonates with hyperbilirubinaemia. Settings and Design-This was a cross-sectional study in neonates admitted to neonatal intensive care unit (NICU). Setting for the research was Dept. of Transfusion Medicine and Neonatology division of Sree Avittom Thirunal Hospital for women and children attached to Govt. Medical College, Trivandrum.

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“…Dr. Diamond's contributions were legion. In 1932, while still a trainee, he largely wrote, but coauthored with Blackfan and Dr. James M. Baty, a long and incisive paper stating that three conditions previously believed to be separate entities, fetal hydrops, icterus gravis familiaris, and anemia of the newborn, were all manifestation of an unknown underlying disease process, which they termed, erythroblastosis fetalis (39). In 1938, Diamond and Blackfan described congenital hypoplastic anemia, which still bears their eponym (40).…”

Section: Pioneers Of American Pediatric Hematologymentioning

confidence: 99%

“…Affected newborns had a 50% mortality and significant neurologic complications occurred in many survivors (42). As previously mentioned, Diamond, Blackfan and Batey were the first to unify three neonatal hematologic syndromes as manifestations of erythroblastosis, but they did not identify a pathophysiologic mechanism (39). In 1938, Dr. Ruth Darrow, a pathologist who had several of her own children die of kernicterus and severe erythroblastosis advanced a brilliant inductive hypothesis about its cause (51).…”

Section: Neonatal Hematologymentioning

confidence: 99%

History of Pediatric Hematology Oncology

Pearson

2002

Pediatr Res

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The following article is the second in this series. Dr. Pearson provides a colorful account of the history of pediatric hematology and oncology and of the pioneers in these fields. He also describes the studies that led to many of the great achievements in medicine, such as the cure of leukemia, the prevention of Rh disease and the understanding and treatment of the hemophilias and hemoglobinopathies. Alvin Zipursky Editor-in-Chief History of Pediatric Hematology Oncology HOWARD A. PEARSON Yale University School of Medicine, New Haven, ConnecticutPediatric Hematology Oncology as a specialty was possible because of the evolution of the science of Hematology, which developed microscopy for describing blood cell morphology and methods for quantitation of these elements. Before pediatric blood diseases could be defined, it was necessary to establish the normal blood values of infancy and childhood. The unique features of the blood of the newborn were the focus of many of the early studies. After normal values were established, specific blood disease and hematologic syndromes of children began to be described in Europe and the United States. Pediatric Hematology Oncology is a broad and complex area that encompasses perturbations of the several-formed elements of the blood and their precursors in the bone marrow, as well as the coagulationfibrinolytic systems in the plasma, the reticuloendothelial system, and malignancies of the blood and solid tissues and organs. The interactions of the blood and nutrition have long been important areas of study. Advances in Pediatric Oncology have been particularly spectacular in the last 50 years. Using multi-modal therapy including combination chemotherapy, more than 80% of children with cancer can now be cured. During the last 50 years, Pediatric Hematology Oncology has increasingly used tools of the "new biology": immunology, biochemistry, enzymology, genetics and molecular genetics, and others. During the last century, many diseases have been recognized and defined by biochemical and genetic mechanisms, and in some instances they have been prevented or cured. The hematology oncology of infancy and childhood is a relatively recent area of study whose development depended upon the evolution of the science of Hematology and, especially, upon methods to study the blood and its elements. As Wintrobe has pointed out, the development of the field of Hematology has been driven by technology. He divided the early evolution of Hematology into two general areas: morphology, which relied on the development of microscopy and quantitation of the elements of the blood, which came later (1).The invention of the microscope enabled identification of the blood cells. Antonj van Leeuwenhoek working in Delft, Holland, constructed a primitive microscope from a minute biconcave lens mounted between two metal plates attached to a screw that permitted focusing. Leeuwenhoek's publication in 1674 contained the first accurate description of the red blood corpuscles (2): The blood is composed of exceedingl...

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Erythroblastosis fetalis and its association with universal edema of the fetus, icterus gravis neonatorum and anemia of the newborn

Cited by 185 publications

References 42 publications

Hemolytic Disease in the Newborn - History and Prevention in the World and the Czech Republic

Hemolytic Disease in the Newborn - History and Prevention in the World and the Czech Republic

Frequency of Antibodies in Haemolytic Disease of Foetus and Newborn

History of Pediatric Hematology Oncology

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