Erythrocyte Catalase and Detoxication of Hydrogen Peroxide

Paniker, N. V.; Iyer, G. Y. N.

doi:10.1139/o65-116

Cited by 34 publications

(5 citation statements)

References 15 publications

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“…The data were similar to a study in dogs with experimental induced DM by alloxan which show higher red blood cell MDA while catalase activity rose and dropped later on (Vajdovich et al 1993). Although catalase activity was reported to be very low in dogs compared with human (Paniker and Iyer 1965;Susuzi et al 1984), the activities were higher in DM dogs in this study compared with control dogs. Since there were positive correlation between RBC-CAT and RBC-TBARS and all DM parameters, therefore, oxidative stress occurs in DM and may be involved in pathogenesis of disease.…”

Section: Discussioncontrasting

confidence: 61%

Oxidative stress and intraerythrocytic concentrations of sodium and potassium in diabetic dogs

et al. 2008

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Oxidative stress parameters; thiobarbituric acid reaction substances (RBC-TBARS), catalase (RBC-CAT) and reduced glutathione (RBC-GSH) and the intraerythrocytic concentrations of electrolytes; sodium and potassium (RBC-Na and RBC-K) were determined in 18 well- controlled (WC) and 22 poorly-controlled diabetic mellitus (DM). Dogs with DM had significant higher blood glucose concentration (P < 0.001), haemoglobin A1c (P < 0.01) and fructosamine (P < 0.001) compared to normal healthy dogs (n = 19). Diabetic dogs in both groups had higher RBC-CAT (P < 0.05) while RBC-TBARS were higher significantly only in poorly-controlled DM group (P < 0.05). The RBC-K was significantly higher in both DM groups (P < 0.001). No changes in RBC-GSH and RBC-Na were found between DM and control healthy dogs. By linear regression analysis, the relationship were found between degree of diabetic mellitus and RBC-CAT, RBC-TBARS, RBC-Na and RBC-K. The relationship was also found between oxidative stress parameters and intraerythrocytic K+. The results suggest that in diabetic dogs, oxidative stress occurs which related to the severity of disease and may affect potassium homeostasis.

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Section: Discussioncontrasting

confidence: 61%

Oxidative stress and intraerythrocytic concentrations of sodium and potassium in diabetic dogs

et al. 2008

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“…It endows catalytic activity to a number of enzymes, including Cu/Zn superoxide dismutase (SOD) (McCord & Fridovich 1969). SOD regulates both intracellular and extracellular oxidative stress by catalysing the breakdown of the potentially toxic superoxide anion to hydrogen peroxide, which is further acted upon by catalase (Paniker & Iyer 1965) Several studies have reported that Western diets, including those provided in hospital and other establishments, are deficient in copper (in Ferns et al 1997). These diets typically provide 0.3-1.5 mg copper per day.…”

Section: Abstract Atherosclerosis Copper Nitric Oxide Superoxide Dmentioning

confidence: 99%

mentioning

confidence: 99%

Dietary copper supplements modulate aortic superoxide dismutase, nitric oxide and atherosclerosis

Lamb

Tickner

Hourani

et al. 2005

Int J Experimental Path

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The objective was to test the hypothesis that dietary copper inhibits atherosclerosis by inducing superoxide dismutase (SOD) and potentiating nitric oxide (NO). New Zealand White rabbits were fed either a cholesterol diet (n = 8) or a cholesterol diet containing 0.02% copper acetate (n = 8) for 13 weeks. We found that the intimal area was significantly smaller in the animals supplemented with copper (P < 0.005), although integrated plasma cholesterol levels were not significantly different. This was associated with a significant increase in aortic copper content (P < 0.05), SOD activity (P < 0.05) and Cu/Zn SOD mRNA (P < 0.05) and a significant decrease in nitrotyrosine content (P < 0.05). Furthermore, there was a positive correlation between aortic copper content and SOD activity (P < 0.005, R(2) = 0.83) and a negative correlation between aortic superoxide dimutase activity and nitrotyrosine content (P < 0.005, R(2) = 0.93). In organ bath experiments, the relaxation of precontracted carotid artery rings to calcium ionophore was greater in animals supplemented with copper. No difference in response to sodium nitroprusside was observed. These data suggest that in the cholesterol-fed rabbit, copper supplements inhibit the progression of atherosclerosis by increasing SOD expression, thereby reducing the interaction of NO with superoxide, and hence potentiating NO-mediated pathways that may protect against atherosclerosis.

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“…Decomposing high concentration of H 2 O 2 in the tumor microenvironment into oxygen can be a potential strategy to increase the intra-tumoral oxygen levels. Catalase (CAT) from mammalian erythrocytes has high enzyme activity of converting H 2 O 2 into water and oxygen, and can be modified onto nanoparticles [ 120 ]. Therefore, reserving the biological activity of CAT nanoparticles and enhancing their permeation into deep hypoxic regions are of great importance for effective tumor oxygenation.…”

Section: Biomimetic Nddssmentioning

confidence: 99%

Nano drug delivery systems improve metastatic breast cancer therapy

et al. 2021

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Despite continual progress in the technologies and regimens for cancer therapy, the treatment outcome of fatal metastatic breast cancer is far from satisfactory. Encouragingly, nanotechnology has emerged as a valuable tool to optimize drug delivery process in cancer therapy via preventing the cargos from degradation, improving the tumor-targeting efficiency, enhancing therapeutic agents’ retention in specific sites, and controlling drug release. In the last decade, several mechanisms of suppressing tumor metastasis by functional nano drug delivery systems (NDDSs) have been revealed and a guidance for the rational design of anti-metastasis NDDSs is summarized, which consist of three aspects: optimization of physiochemical properties, tumor microenvironment remodeling, and biomimetic strategies. A series of medicinal functional biomaterials and anti-metastatic breast cancer NDDSs constructed by our team are introduced in this review. It is hoped that better anti-metastasis strategies can be inspired and applied in clinic.

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Erythrocyte Catalase and Detoxication of Hydrogen Peroxide

Cited by 34 publications

References 15 publications

Oxidative stress and intraerythrocytic concentrations of sodium and potassium in diabetic dogs

Oxidative stress and intraerythrocytic concentrations of sodium and potassium in diabetic dogs

Dietary copper supplements modulate aortic superoxide dismutase, nitric oxide and atherosclerosis

Nano drug delivery systems improve metastatic breast cancer therapy

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