Erythrocyte filterability in the burned patient

Johnson, George; Lineberger, Thomas; Hothem, Arden L.; Hinson, T.; Winkenwerder, William

doi:10.1016/0305-4179(79)90004-4

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…Disruption of the blood flow in this zone occurs as a result of pathologic changes in the microvascular level. [25] These changes include the formation of microthrombi, adhesion of the neutrophils to the vessel wall, fibrin deposition, edema in endothelium, and vasoconstriction. [26] Disruption of blood flow occurs within 2-3 h of severe burns.…”

Section: Discussionmentioning

confidence: 99%

Recovery of Burn Stasis Zone Using Pentoxifylline and Milrinone in an Experimental Burn Model Established For Rats

Mollaoğlu,

Atabey,

Emre Bostanci

et al. 2019

Ascl Med Res Rev

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Aim:The aim of this study is to investigate the effect of pentoxifylline (PTX) and milrinone on the stasis zone in rats for which an experimental burn model was established. Method: In this study with an experimental design, PTX and milrinone -5-phosphodiesterase inhibitors -were administered orally and intraperitoneally to rats for which an experimental burn model was created. The effects of these pharmacological agents on the stasis zone and comparison of these effects with each other were investigated. In the study, 56 4-monthold female rats of Wistar albino type with a weight of 200 ± 10% g were used. The rats were divided into seven groups. The burn model defined by Regas and Erlich was applied to 48 rats under anesthesia. Groups 1, 2, and 3 were defined as the sham group, intraperitoneal control group, and oral control group, respectively. Drugs were administered to groups for 10 days as follows: PTX intraperitoneally daily at a dose of 50 mg/kg to Group 4, PTX orally daily at a dose of 50 mg/kg to Group 5, milrinone intraperitoneally daily at a dose of 1 mg/kg to Group 6, and milrinone orally daily at a dose of 1 mg/kg to Group 7. All rats were sacrificed on the 10 th day of the experiment. Serum samples for the biochemical levels of malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase were taken as well as tissue samples for the histopathological study of these. Results: Pathologically, edema, hyperemia, epithelial degeneration, necrosis, inflammatory filtration, and fibrosis measurements were taken. Compared to the control group, the tissue damage score was lower in all treated groups. MDA levels were lower in the intraperitoneal and oral PTX administered group than in the control group, while SOD, catalase, and GPx levels were higher. MDA levels were lower in the intraperitoneal and oral milrinoneadministered group than in the control group, and SOD, catalase, and GPx levels were higher. In addition, it was found that MDA levels were lower and SOD, catalase, and GPx levels were higher in the intraperitoneal PTX-administered group than in the intraperitoneal milrinone-administered group. It was found that MDA levels were lower and SOD, catalase, and GPx levels were higher in the oral PTX-administered group than in the oral milrinone-administered group. Conclusion: As a result of our study, it was shown that PTX and milrinone reduce oxidative stress and have positive effects, improving wound healing in the burn model established for the rats.

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Section: Discussionmentioning

confidence: 99%

Recovery of Burn Stasis Zone Using Pentoxifylline and Milrinone in an Experimental Burn Model Established For Rats

Mollaoğlu,

Atabey,

Emre Bostanci

et al. 2019

Ascl Med Res Rev

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“…No caso em que ocorrer a queimadura de segundo grau superficial, a recuperação é em torno de duas semanas , ou até menos em alguns casos, gerando tegumento com capacidade similar a pele sadia com mínima alteração de cor. No entanto, a problemática de diagnóstico se configura a partir das lesões térmicas mais profundas [17].…”

Section: Peleunclassified

“…Fontes: Adaptado de [10] A região mais central, zona de coagulação, dificilmente é recuperada devido ao dano celular severo gerando assim uma necrose tecidual. Na zona de estase a congestão sanguínea se intesifica devido a fatores inflamatórios no local, tais como aderência de neutrófilos à parede dos vasos e deposição de fibrina [17,18].…”

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Espectroscopia de absorção no infravermelho em pele queimada: avaliação de potenciais biomarcadores para o reparo tecidual

Castro¹

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Viscous factors in peripheral tissue perfusion

Johnson¹,

Keagy²,

Ross³

et al. 1985

Journal of Vascular Surgery

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To ascertain the relative importance of the factors that influence blood viscosity (VIS), we measured hematocrit (HCT), filterability index, fibrinogen level (FIB), and Ektacytometer indices at osmolarities of both 290 (EI 290) and 200 (EI 200) in 21 diabetic patients with peripheral vascular disease (DPVDs) and 11 healthy volunteers (HVs). Stepwise multiple regression analyses generated a formula based on three of the independent variables (FIB, HCT, EI 200) that accurately predicted VIS (r = 0.79, p less than 0.01). Based on the beta coefficients and F statistics, HCT and FIB were the most important elements in the linear regression equation. Compared with HVs the total group of DPVDs had lower HCT (36.5% vs. 42.4%) and higher FIB (661 vs. 276 mg/dl, p less than 0.01) values. When all HVs were compared with a subgroup of DPVDs with similar HCT (n = 10), both FIB and VIS were higher (p less than 0.001) in the DPVD than in the HV group. We conclude that the most important of the multiple factors that influence VIS are HCT and FIB. The finding of increased FIB in DPVDs could have important implications for drug and surgical therapy in this group of patients.

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Erythrocyte filterability in the burned patient

Cited by 4 publications

References 7 publications

Recovery of Burn Stasis Zone Using Pentoxifylline and Milrinone in an Experimental Burn Model Established For Rats

Recovery of Burn Stasis Zone Using Pentoxifylline and Milrinone in an Experimental Burn Model Established For Rats

Espectroscopia de absorção no infravermelho em pele queimada: avaliação de potenciais biomarcadores para o reparo tecidual

Viscous factors in peripheral tissue perfusion

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