Erythrocyte glutathione <i>S</i>-transferase. Electrophoretic identification of two enzyme forms

Strange, Richard C.; Hirrell, P H; Kitley, G A; Hopkinson, D. A.; Cotton, William

doi:10.1042/bj2150213

Cited by 14 publications

(1 citation statement)

References 8 publications

(12 reference statements)

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“…Normal erythrocyte GST activities towards CDNB vary considerably between individuals (6-10 fold) [125,141] (also confirmed in this thesis), and it was suggested early that the cause might be undetected (genetic) variation [142]. Fazi and coworkers showed that GSTp actually exists in two forms [50] that can be separated using ion-exchange chromatography.…”

Section: Glutathione S-transferasesupporting

confidence: 62%

Toxicological stress indicators in human red blood cells : changes in glutathione and glutathione S-transferase as biological markers for electrophilic and oxidative stress

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Section: Glutathione S-transferasesupporting

confidence: 62%

Toxicological stress indicators in human red blood cells : changes in glutathione and glutathione S-transferase as biological markers for electrophilic and oxidative stress

Evelo¹

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The Isoenzymes of Glutathione Transferase

Mannervik

1985

Advances in Enzymology - And Related Areas of Molecular Biology

483

146

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The human glutathione S-transferases: Developmental aspects of the GST1, GST2, and GST3 loci

et al. 1985

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The expression of the GST1, GST2, and GST3 loci in fetal, neonatal, and infant tissues has been studied using starch gel electrophoresis and chromatofocusing. Each locus demonstrated developmental changes in expression, some of which were specific to a single tissue while others occurred in several tissues. GST1 was not usually expressed in any of the tissues studied before 30 weeks of gestation but steadily increased thereafter until adult levels were reached in late infancy. In neonates and older infants the frequencies of the GST1*0, GST1*1, and GST1*2 alleles were 0.79, 0.07, and 0.14, respectively. GST2 was always expressed in liver and adrenal but was only weakly expressed in spleen, cardiac muscle, and diaphragm. In kidney this locus was not usually expressed until nearly 1 year after birth. The GST3 isoenzymes were present in all fetal, neonatal, and infant tissues, although their expression in liver decreased after 30 weeks of gestation. Other isoenzymes with fast anodal mobilities were also identified in several tissues; these are believed to be GST3 isoenzymes that have undergone posttranslational modification rather than products of the putative GST4 locus. No specifically fetal isoenzymes were detected.

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Erythrocyte glutathione S-transferase. Electrophoretic identification of two enzyme forms

Abstract: Starch-gel electrophoresis was used to demonstrate two forms of glutathione S-transferase in human erythrocytes. Whereas considerable inter-individual differences in enzyme activity and electrophoretic patterns were detected, intra-individual differences were small.

Cited by 14 publications

References 8 publications

Toxicological stress indicators in human red blood cells : changes in glutathione and glutathione S-transferase as biological markers for electrophilic and oxidative stress

Toxicological stress indicators in human red blood cells : changes in glutathione and glutathione S-transferase as biological markers for electrophilic and oxidative stress

The Isoenzymes of Glutathione Transferase

The human glutathione S-transferases: Developmental aspects of the GST1, GST2, and GST3 loci

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