2009
DOI: 10.1016/j.plefa.2008.12.005
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Erythrocyte membrane and plasma non-esterified n-3 and n-6 polyunsaturated fatty acids of pregnant and non-pregnant Brazilian adolescents

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Cited by 5 publications
(4 citation statements)
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“…Corroborating our findings, lower levels of DHA, total n -3 PUFA and LCPUFA have been previously reported in Brazilian pregnant adolescents of similar socioeconomic condition using erythrocyte FA profile to assess PUFA status [ 29 ]. Even though we have not directly accessed the participant’s dietary intake, we speculate that this could be related to the lipid composition of maternal diet, as evidence on the dietary pattern of Brazilian pregnant and lactating adolescents suggest relatively high intake of n -6 PUFA, especially LA, and low consumption of n -3 LCPUFA, particularly DHA [ 29 , 30 , 31 ]. In addition, endogenous n -3 conversion of ALA to DHA may be inhibited by high dietary levels of the n -6 precursor LA, since both ALA and LA compete as substrates for ∆-6 desaturase, and this may further enhance the reliance upon maternal dietary intake of preformed DHA to meet fetal demands [ 32 ].…”
Section: Discussionsupporting
confidence: 89%
“…Corroborating our findings, lower levels of DHA, total n -3 PUFA and LCPUFA have been previously reported in Brazilian pregnant adolescents of similar socioeconomic condition using erythrocyte FA profile to assess PUFA status [ 29 ]. Even though we have not directly accessed the participant’s dietary intake, we speculate that this could be related to the lipid composition of maternal diet, as evidence on the dietary pattern of Brazilian pregnant and lactating adolescents suggest relatively high intake of n -6 PUFA, especially LA, and low consumption of n -3 LCPUFA, particularly DHA [ 29 , 30 , 31 ]. In addition, endogenous n -3 conversion of ALA to DHA may be inhibited by high dietary levels of the n -6 precursor LA, since both ALA and LA compete as substrates for ∆-6 desaturase, and this may further enhance the reliance upon maternal dietary intake of preformed DHA to meet fetal demands [ 32 ].…”
Section: Discussionsupporting
confidence: 89%
“…The standard diet of pregnant adolescents and adults in Brazil shows a prevalence of n-6 series fatty acid food sources, like vegetable oils, mainly soy oil, as opposed to n-3 sources, like fish and fish oil, resulting in a high n-6/n-3 ratio in their diet [37,40]. …”
Section: Discussionmentioning
confidence: 99%
“…For all methodologies, based on literature data, BHT was used as antioxidant to prevent samples FA degradation, C19:0 was used as IS and BF 3 as a catalyst for FA methylation. BHT, a synthetic antioxidant frequently included in routine analyses [33][34][35], was used since it promotes PUFA stability during long-term storage of RBCs (4-17 weeks) at −20 °C [42]. C19:0 was selected as IS because this odd-chain FA has a microbial origin, therefore inexistent or being present only at trace levels in animal tissues [43].…”
Section: Comparison Of Sample Preparation Methodologiesmentioning
confidence: 99%