Erythrocyte membrane cation carrier in manic-depressive psychosis

Naylor, G. J.; Smith, Anne H. W.; Dick, E. G.; Dick, D. A. T.; McHarg, Anne M.; Chambers, Catherine A.

doi:10.1017/s0033291700047413

Cited by 55 publications

(11 citation statements)

References 14 publications

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“…However, Naylor et al (1977) failed to find any effect of lithium on Na+-K+ ATPase activity in healthy subjects, which could explain our inability to find any interaction. Though a decrease in Na+-K+ ATPase activity has been found in patients suffering from affective disorders (Naylor et al, 1980;Whalley et al, 1980) this is not a universal finding (Akagawa et al, 1980;Sengupta et al, 1980) and may be related to changes in plasma cortisol concentration (Numberger et al, 1982). Furthermore, while Naylor et al (1977) have demonstrated an increase in Na+-K+-ATPase activity in manicdepressive patients following lithium treatment this was not found by Numberger et al (1982).…”

Section: Discussionmentioning

confidence: 99%

Pharmacodynamics and pharmacokinetics of digoxin in the presence of lithium.

Cooper¹,

Kelly²,

Johnston³

et al. 1984

Brit J Clinical Pharma

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Previous biochemical and clinical data suggest there may be an interaction between digoxin and lithium. The pharmacodynamics and pharmacokinetics of an intravenous infusion of digoxin were studied in six male subjects before and after 2 weeks treatment with lithium carbonate. The effects of lithium on sodium pump activity, intracellular electrolytes and extracellular electrolytes were studied. No significant interaction between digoxin and lithium was found. No significant effects of lithium on sodium pump activity or electrolyte concentrations were found.

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Section: Discussionmentioning

confidence: 99%

Pharmacodynamics and pharmacokinetics of digoxin in the presence of lithium.

Cooper¹,

Kelly²,

Johnston³

et al. 1984

Brit J Clinical Pharma

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“…Soon after the characterization of the Na + /K + ‐ATPase, some authors investigated its activity in mood disorders. These studies showed that Na + pump activity is decreased in acute mania compared to recovered euthymic bipolar individuals (Reddy et al, 1992; Hesketh et al, 1977; Naylor et al, 1980). Besides, reduced enzyme activity of Na + /K + ‐ATPase and increased intracellular sodium and calcium in erythrocytes of bipolar patients have been reported (Looney and El‐Mallakh, 1997).…”

Section: Methodsmentioning

confidence: 99%

Intracerebroventricular ouabain administration induces oxidative stress in the rat brain

Riegel

Valvassori²,

Moretti³

et al. 2010

Intl J of Devlp Neuroscience

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Intracerebroventricular (ICV) injection of ouabain (a potent Na(+)/K(+)-ATPase inhibitor) in rats resulted in manic-like effects. There is an emerging body of data indicating that major neuropsychiatric disorders, such as bipolar disorder and schizophrenia, are associated with increased oxidative stress. In this study, we investigated the effects of ICV ouabain injection on oxidative stress parameters in total tissue of rat brain. Our findings demonstrated that ICV injection increased thiobarbituric acid reactive species levels and protein carbonyl generation in the prefrontal cortex and hippocampus of rats. Moreover, the activity of the antioxidants enzymes catalase and superoxide dismutase was altered in several areas of the rat brain and cerebrospinal fluid of ICV ouabain-subjected rats. These results showed that Na(+)/K(+)-ATPase inhibition can lead to oxidative stress in the brain of rats.

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“…Some authors have investigated the activity of Na + /K + -ATPase in mood disorders [34,35]. The model of BD and mania utilized in this study is the OUA model.…”

Section: Discussionmentioning

confidence: 99%