Erythrocyte Membrane Fatty Acid Composition in Premenopausal Patients with Iron Deficiency Anemia

Aktaş, Mehmet; Elmastaş, Mahfuz; Özçıçek, Fatih; Yilmaz, Necmettin

doi:10.5650/jos.ess15211

Cited by 12 publications

(7 citation statements)

References 26 publications

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“…In this study, palmitic acid (C16:0) concentration was the highest among other SFAs in maternal and cord blood (Table 2). These findings are in line with previous studies which stated that palmitic acid is the principal constituent of fatty acids found in human tissues, such as in serum (Liu et al 2017;Yammine et al 2018), red blood cell (Aktas et al 2016), adipose tissue (Shramko et al 2020) and other human tissues in general (Ruiz-Nunez et al 2016). This pattern remains consistent when compared to Spanish vegetarian population (Salvador et al 2019), and Italian or Tibetan population (Rise et al 2008) whose main dietary oil is olive, sunflower, mustard, canola, and corn oil.…”

Section: Maternal and Cord Blood' Sfa Profilesupporting

confidence: 93%

Maternal and Cord Blood Saturated Fatty Acid Level and Infant Adiposity

Yustiyani¹,

Anwar²,

Dewi³

2021

Jgizipangan

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This study aimed to assess SFAs profiles in the maternal and cord blood, and the relationship of both SFAs levels with infant adiposity. As many as 99 mothers with singleton pregnancy and pre-pregnancy BMI ≥18.5 agreed to join the research and completed the data collection process. Maternal and cord blood erythrocyte SFAs profile was analyzed using Gas Chromatography-Flame Ionized Detector. Infant birth weight was measured at birth, while infant skinfolds were at 5-7 days postpartum. We used Aris et al. (2013) equation to assess the infant fat mass. The average maternal age was 29.62±5.84 years old, while the pre-pregnancy BMI was 22.87±3.90 kg/m 2 . Infant birth weight was 3168.83±341.64 g, and fat mass was 9.39±3.52 %. Maternal total SFAs and palmitic acid (C16:0) concentration were higher than cord blood, while lignoceric acid (C24:0) was lower (p<0.05). Increased maternal caproic (C6:0), capric (C10:0), and lauric acids (C12:0) were associated with higher infant adiposity (p<0.05). Total SFAs, palmitic (C16:0), stearic (C18:0), and behenic acids (C22:0) in cord blood were negatively associated with infant adiposity (p<0.05). Elevated lauric (C12:0) and myristic (C14:0) acids in cord blood were associated with greater adiposity. In conclusion, we found a different SFAs profile between maternal blood during the third trimester of pregnancy and cord blood. Increased maternal caproic, capric, and lauric acids as well as cord blood's lauric and palmitic acids contribute to greater infant adiposity.

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Section: Maternal and Cord Blood' Sfa Profilesupporting

confidence: 93%

Maternal and Cord Blood Saturated Fatty Acid Level and Infant Adiposity

Yustiyani¹,

Anwar²,

Dewi³

2021

Jgizipangan

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“…Similar to some other authors, we have demonstrated that MHT elevates particular SFAs and negatively affects the concentration of UFA, however, a skewed lipid profile may be present during aging process, independent of hormone use. This was suggested by a 2016 study [54] of 102 premenopausal women with iron deficiency anemia and 88 healthy women, the results of which demonstrated that, in both groups, the most prevalent fatty acids were palmitic acid, oleic acid, linoleic acid, stearic acid, and erucic acid. Such age-dependent alterations in fatty acid profiles have been documented before [55].…”

Section: Discussionmentioning

confidence: 91%

Fatty Acid Profile of Postmenopausal Women Receiving, and Not Receiving, Hormone Replacement Therapy

Cybulska

Skonieczna-Żydecka

Drozd

et al. 2019

IJERPH

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Menopause, the permanent cessation of the menstrual cycle, marks the end of a woman’s reproductive lifespan. Menopausal hormonal therapy (MHT) can potentially skew the fatty acid profile increasing the risk for developing metabolic diseases and disorders of skeletal, gastrointestinal, and nervous systems. The aim of this study was to investigate the fatty acid profile of postmenopausal women receiving, and not receiving, hormone replacement therapy. A total of 156 healthy women with a mean age of 60 participated in this cross-sectional study. Gas chromatography with an Agilent Technologies 7890A GC system was used to determine fatty acid content. Statistical analysis was conducted using R software, version 3.4.1. Women receiving MHT had significantly higher (p < 0.05) concentrations of C14:0 and C16:0. MHT was found to be associated with a tendency (p = 0.053) to diminish concentrations of C18:1n-9, C20:4, and all unsaturated fatty acids (p < 0.05). The longer MHT was used, the higher the concentration of C24:1 (p = 0.04) and the lower the concentration of C18:2n-6 (p = 0.03).

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“…We speculated that the lower status of both vitamin B6 and iron in younger women than in men might contribute to the gender-specific relationship between plasma PLP and plasma PUFA in younger adults [ 35 ]. The deficiency or depletion of iron, present in the terminal protein of the D6D enzyme [ 71 ], may modify PUFA metabolism [ 72 , 73 , 74 , 75 , 76 ]. Furthermore, D6D activity may be impaired by vitamin B6 deficiency, thereby inhibiting the synthesis of longer chain PUFA [ 6 , 11 , 26 , 66 ].…”

Section: Discussionmentioning

confidence: 99%

Associations of Vitamin B6 Intake and Plasma Pyridoxal 5′-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003–2004

et al. 2022

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Previous evidence suggests a potential dual impact of aging and vitamin B6 (B6) deficiency on polyunsaturated fatty acid (PUFA) metabolism; gender may influence PUFA biosynthesis. Perturbation of PUFA compositions during B6 deficiency could be linked to age-related health outcomes. However, little is known about the interrelationships between vitamin B6, PUFA, and gender in the older population. Therefore, we investigated whether gender-specific associations of B6 intake and plasma pyridoxal 5’-phosphate (PLP) concentration, respectively, with plasma PUFA concentrations and ratios (eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), arachidonic acid (AA), EPA + DHA, EPA/AA, and (EPA + DHA)/AA) existed in older adults. We further examined the relationships of adequate B6 status (PLP ≥ 20 nmol/L) with high (above median) plasma PUFA relative to deficient B6 status. This cross-sectional study analyzed 461 participants aged ≥60 years from NHANES 2003–2004. Nutrient intakes were assessed using two 24-h recalls and supplement questionnaires. PLP and PUFA concentrations were measured. Multivariate linear regression assessed the association of B6 intake and PLP with PUFA; multivariate logistic regression evaluated the relationship of adequate B6 status with high plasma PUFA, adjusting for demographic, socioeconomic, and dietary factors; physical activity; smoking; alcohol; medication; and BMI. There were interactions between gender and B6 intake on EPA (P-interaction = 0.008) and AA (P-interaction = 0.004) only, whereas no interaction existed between gender and PLP on PUFA. PLP was directly associated with EPA (β = 0.181, P = 0.002), DHA (β = 0.109, P = 0.005), EPA + DHA (β = 0.14, P = 0.002), EPA/AA (β = 0.186, P = 0.004), and (EPA + DHA)/AA (β = 0.13, P = 0.026). The odds of having high plasma EPA (adjusted (a) OR: 2.03, P = 0.049) and EPA/AA (aOR: 3.83, P < 0.0001) were greater in those with adequate B6 status compared to those with deficient B6 status. In conclusion, in US older adults, a higher PLP level was associated with a greater level of EPA, DHA, EPA + DHA, EPA/AA, and (EPA + DHA)/AA. Adequate B6 status was associated with high EPA and EPA/AA status. These findings suggest that sufficient vitamin B6 status may positively influence PUFA metabolism in older adults.

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Erythrocyte Membrane Fatty Acid Composition in Premenopausal Patients with Iron Deficiency Anemia

Cited by 12 publications

References 26 publications

Maternal and Cord Blood Saturated Fatty Acid Level and Infant Adiposity

Maternal and Cord Blood Saturated Fatty Acid Level and Infant Adiposity

Fatty Acid Profile of Postmenopausal Women Receiving, and Not Receiving, Hormone Replacement Therapy

Associations of Vitamin B6 Intake and Plasma Pyridoxal 5′-Phosphate with Plasma Polyunsaturated Fatty Acids in US Older Adults: Findings from NHANES 2003–2004

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