Erythrocyte membrane fatty acid profile in patients with primary carcinoma of the gallbladder

Abstract

Erythrocyte fatty acids were determined in patients with gall stones and carcinoma of the gallbladder. Significantly low levels of myristic acid (P < 0.01) and stearic acid (P < 0.001) and significantly high levels of palmitoleic acid (P < 0.05) and oleic acid (P < 0.01) were observed in cancer patients. Arachidonic and linolenic acid were significantly high in gallstone patients, but there was no significant difference in the lauric acid and palmitic acid levels. Thus an altered lipid metabolism in cancer patients suggest existence of a possible association between gallstones, fatty acids, and carcinoma of the gallbladder.

Erythrocyte membrane fatty acid profile and saturation index in gallbladder carcinogenesis: a case-control study

“…Although not much delta 9 desaturation was seen in the present study when compared to the results of our earlier study [11], however this may be due to less number of patients in our earlier study and high variance thus observed. We had earlier proposed a role of free radical mediated lipid peroxidation in gallbladder carcinogenesis, however, our attention was subsequently drawn to the relationship of lipid peroxidation product 4-hydroxynonenal (HNE) and electrolytes suggesting that increase in lipid peroxidation products was probably due to increased stasis rather than increased peroxidation [12].…”

“…Similar to the results of our earlier study [11], the present study too show a fall in concentration of arachidonic acid in patients with gallbladder cancer, compared to patients with cholelithiasis, however, absence of a normal control group preclude the exact interpretation of this observation. Although not much delta 9 desaturation was seen in the present study when compared to the results of our earlier study [11], however this may be due to less number of patients in our earlier study and high variance thus observed.…”

Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update

“…Role of allele specific mutations in pathogenesis of carcinoma gallbladder has also been reported[54]. Another report by Pandey et al[55] has shown higher frequency of carcinoma gallbladder in patients with A+ and AB+ blood groups to which the reason is still unknown.…”

Fatty-acid composition in serum phospholipids and risk of breast cancer: An incident case-control study in Sweden

“…Decreased level of stearic acid in red-cell membranes, as well as (Wood et al, 1985;Kelly et al, 1990;Persad et al, 1990;Pandey et al, 1995). In addition, a prospective study of survival of breast-cancer patients showed a strong negative association between risk of metastases and stearic-acid level in membrane phosphatidylcholine in the primary tumor (Bougnoux et al, 1992).…”