Erythrocyte membrane phospholipid composition is related to hyperinsulinemia in obese nondiabetic women: Effects of weight loss

Younsi, Mohamed; Quilliot, Didier; Al-Makdissy, Nehmann; Delbachian, Ir ne; Drouin, P; Donner, M.; Ziegler, O.

doi:10.1053/meta.2002.35184

Cited by 36 publications

(24 citation statements)

References 51 publications

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“…Still, it is interesting to see that there is consistency as well as inconsistency concerning metabolomic changes related to obesity. Our findings of obesity-associated changes in acylcarnitine, acyl-alkyl PC, LPC and SM concentrations are largely in concordance with earlier studies in adults [9,10,12,44,45]. In contrast, the results concerning amino acid concentrations in our study of obese children deviate from findings in adults.…”

Section: Discussionsupporting

confidence: 91%

Childhood Obesity Is Associated with Changes in the Serum Metabolite Profile

et al. 2012

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Objective: The human serum metabolite profile is reflective of metabolic processes, including pathophysiological changes characteristic of diseases. Therefore, investigation of serum metabolite concentrations in obese children might give new insights into biological mechanisms associated with childhood obesity. Methods: Serum samples of 80 obese and 40 normal-weight children between 6 and 15 years of age were analyzed using a mass spectrometry-based metabolomics approach targeting 163 metabolites. Metabolite concentrations and metabolite ratios were compared between obese and normal-weight children as well as between children of different pubertal stages. Results: Metabolite concentration profiles of obese children could be distinguished from those of normal-weight children. After correction for multiple testing, we observed 14 metabolites (glutamine, methionine, proline, nine phospholipids, and two acylcarnitines, p < 3.8 × 10^–4) and 69 metabolite ratios (p < 6.0 × 10^–6) to be significantly altered in obese children. The identified metabolite markers are indicative of oxidative stress and of changes in sphingomyelin metabolism, in β-oxidation, and in pathways associated with energy expenditure. In contrast, pubertal stage was not associated with metabolite concentration differences. Conclusion: Our study shows that childhood obesity influences the composition of the serum metabolome. If replicated in larger studies, the altered metabolites might be considered as potential biomarkers in the generation of new hypotheses on the biological mechanisms behind obesity.

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Section: Discussionsupporting

confidence: 91%

Childhood Obesity Is Associated with Changes in the Serum Metabolite Profile

et al. 2012

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“…In this study, membrane phospholipids increased in diabetic group and decreased again by Omega-3 administration, this result was in agreement with another study which indicated that the amount of dietary fat as well as the nature of fatty acids regulate various steps in the biosynthesis of membrane phospholipids, thus, total PL, PC, PE and SM in rats fed a diet high in saturated fat were 1.7, 1.5, 2 and 5 fold respectively higher than in rats fed on an unsaturated high fat diet [30].…”

Section: Discussionsupporting

confidence: 91%

Effect of Omega-3 Fatty Acids on Erythrocyte Membrane in Diabetic Rats

Hussein¹,

Mostafa²,

El-Waseef³

et al. 2011

Macedonian Journal of Medical Sciences

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“…Significant health benefits can be expected from an increase in erythrocyte membrane fluidity and, more in general, of other tissues, including muscles and adipocytes, where changes in membrane composition, and consequently fluidity, have been correlated to those of erythrocytes [28][29][30]. First, improved membrane fluidity has been shown to increase the rate of oxygen exchange between erythrocytes and tissue [31] and, consequently, oxygen-dependent aerobic metabolism and thermogenesis, thus, facilitating the greater weight loss shown in Group II.…”

Section: Discussionmentioning

confidence: 99%