Erythrocyte, plasma, and serum antioxidant activities in untreated toxic multinodular goiter patients

Alicigüzel, Yakup; Özdem, Sebahat; Özdem, Sadi S.; Karayalçın, Ümit; Siedlak, Sandra L.; Perry, George; Smith, Mark A.

doi:10.1016/s0891-5849(00)00509-8

Cited by 36 publications

(36 citation statements)

References 37 publications

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“…There are a few studies about the role of Se status in thyroid function in humans. Decreased Se concentration was observed in hyperthyroid patients within a Se-deficient population [26]. In the present study, goitrous subjects had significant lower Se levels than nongoitrous ones.…”

Section: Discussionsupporting

confidence: 54%

Selenium Deficiency as a Possible Contributor of Goiter in Schoolchildren of Isfahan, Iran

Keshteli

Hashemipour

Siavash

et al. 2008

Biol Trace Elem Res

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The prevalence of goiter still remains high in some areas of Iran in spite of iodine supplementation. In the present study, we investigated the role of selenium (Se) deficiency in the etiology of goiter in Isfahan. Two thousand three hundred thirty-one schoolchildren were selected by multistage random sampling. Thyroid size was estimated in each child by inspection and palpation. Urinary iodine concentration (UIC) and plasma Se were measured. Overall, 32.9% of the 2,331 children had goiter. The median UIC was 19.55 microg/dl. Plasma Se was measured in 96 goitrous and 72 nongoitrous children. The mean +/- SD of plasma Se in goitrous and nongoitrous children was 66.86 +/- 21.82 and 76.67 +/- 23.33 microg/l, respectively (P = 0.006). Goitrous girls had lower plasma Se level than nongoitrous girls (65.62 +/- 21.64 vs. 76.51 +/- 22.61 microg/dl, P = 0.02). Goitrous boys had lower plasma Se level than nongoitrous boys (68.45 +/- 22.21 vs. 76.91 +/- 24.76 microg/l, P = 0.14). The prevalence of Se deficiency was significantly higher in goitrous boys and girls than nongoitrous children. Se deficiency is among the contributors of goiter in Isfahan goitrous schoolchildren. However, the role of other micronutrient deficiencies or goitrogens should be investigated in this region.

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Section: Discussionsupporting

confidence: 54%

Selenium Deficiency as a Possible Contributor of Goiter in Schoolchildren of Isfahan, Iran

Keshteli

Hashemipour

Siavash

et al. 2008

Biol Trace Elem Res

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“…Data in humans are sparse. An observational study in a selenium-deficient population showed decreased selenium levels in a small series of hyperthyroid patients compared with control subjects (26). In Northern Zaire, a selenium-deficient area, 2 months of selenium supplementation without prior iodine supplementation resulted in a marked fall in total T 4 levels among schoolchildren, and aggravated hypothyroidism in myxoedematous cretins (7).…”

Section: Discussionmentioning

confidence: 99%

Association of selenium with thyroid volume and echostructure in 35- to 60-year-old French adults

Derumeaux

Valeix

Castetbon³

et al. 2003

European Journal of Endocrinology

136

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Objective: To investigate the relationship between selenium status, thyroid volume and gland echostructure. Design: Cross-sectional. Methods: In 792 men (45-60 years) and 1108 women (35-60 years) from the SU.VI.MAX study, thyroid volume and gland echostructure were determined ultrasonographically. At baseline, thyrotropin, free thyroxine, selenium, zinc, a-tocopherol, b-carotene, retinol, urinary iodine and thiocyanate concentrations were measured. Alcohol consumption, smoking, and menopausal status were assessed by a questionnaire. A stepwise linear and a logistic regression model were used, adjusting for antioxidant vitamins, trace elements status and age. Results: In women, there was an inverse association between selenium status and thyroid volume ðP ¼ 0:003Þ: A protective effect of selenium against goiter (odds ratio ðORÞ ¼ 0:07; 95% confidence interval ðCIÞ ¼ 0:008 -0:6) and thyroid tissue damage ðOR ¼ 0:2; 95% CI ¼ 0:06 -0:7Þ was observed. There was no evidence of an association between menopausal status and other antioxidant elements, thyroid volume or thyroid hypoechogenicity. Smoking, but not alcohol consumption, was associated with an increased risk of thyroid enlargement in women ðOR ¼ 3:94; 95% CI ¼ 1:64 -9:48Þ: No association between thyroid volume, thyroid structure or selenium was found in men. Conclusion: Our findings suggest that selenium may protect against goiter. Selenium was related to thyroid echostructure, suggesting it may also protect against autoimmune thyroid disease.

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“…Activity of GPX1 is found to be negatively associated with smoking [7][8][9] and positively associated with dietary supplements [7,9], indicating a lifestyle-factor impact on enzyme activity. The activity is elevated in subjects with untreated hyperthyroidism [10]. Low activity is predictive of a poor prognosis for cardiovascular events in patients with coronary artery disease [8].…”

Section: Roohz2gsh?gssgzh 2 Ozrohmentioning

confidence: 99%

Sex determines the influence of smoking and gene polymorphism on glutathione peroxidase activity in erythrocytes

Malling

Sigsgaard²,

Andersen

et al. 2009

Scandinavian Journal of Clinical and Laboratory Investigation

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Erythrocyte, plasma, and serum antioxidant activities in untreated toxic multinodular goiter patients

Cited by 36 publications

References 37 publications

Selenium Deficiency as a Possible Contributor of Goiter in Schoolchildren of Isfahan, Iran

Selenium Deficiency as a Possible Contributor of Goiter in Schoolchildren of Isfahan, Iran

Association of selenium with thyroid volume and echostructure in 35- to 60-year-old French adults

Sex determines the influence of smoking and gene polymorphism on glutathione peroxidase activity in erythrocytes

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