Erythrocyte rheological properties but not whole blood and plasma viscosity are associated with severity of hypertension in older people

Fu, Guoxiang; Ji, Min; Han, Li-Zhi; Chen, Xu; Pan, Feng-Feng; Hu, Ting‐Jun; Zhong, Yuan

doi:10.1007/s00391-016-1039-8

Cited by 21 publications

(14 citation statements)

References 26 publications

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“…Evidence from the literature confirms that impaired haemorheological properties are associated with pathologies such as sepsis 1 , sickle cell anaemia 2, 3 , diabetes 4 , gynaecologic malignancy 5 and cardiovascular diseases 6–9 . The early manifestation of impaired haemorheological properties makes it a potential biomarker for the detection and screening of a number of pathologies.…”

Section: Introductionmentioning

confidence: 98%

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Photoplethysmography for the Assessment of Haemorheology

Njoum

Kyriacou

2017

Sci Rep

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Haemorheology has been long identified as an early biomarker of a wide range of diseases, especially cardiovascular diseases. This study investigates for the first time the suitability of Photoplethysmography (PPG) as a non-invasive diagnostic method for haemorheological changes. The sensitivity of both PPG components (AC and DC) to changes in haemorheology were rigorously investigated in an in vitro experimental setup that mimics the human circulation. A custom-made reflectance PPG sensor, a pressure transducer and an ultrasonic Doppler flowmeter were used to map changes in flow dynamics and optical responses in an arterial model. The study investigated the effect of shear rates by varying fluid pumping frequencies using 4 set-points and the effect of clot formation using a chemical trigger. Both PPGAC amplitudes and PPGDC levels showed significant (p < 0.001) changes during the increase in shear rates and an immediate change after thromboplastin activation. The findings highlight that PPG has the potential to be used as a simple non-invasive method for the detection of blood characteristics, including disaggregation, radial migration and cross-linking fibrin formations. Such capability will enable the assessment of the effects of clotting-activators and anticoagulants (including non-pharmacological methods) and might aid in the early non-invasive assessment of cardiovascular pathologies.

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Section: Introductionmentioning

confidence: 98%

“…Particularly in cardiovascular patients, there is a plethora of evidence that points to the association of hyperviscosity in the increased risk of complications 6, 8–11 . Platelet activation is also a major factor in the progression of atherosclerosis and lesion formation 12–15 .…”

Section: Introductionmentioning

confidence: 99%

Photoplethysmography for the Assessment of Haemorheology

Njoum

Kyriacou

2017

Sci Rep

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“…Generally, the blood viscosity does not change over smaller distances and time periods. When viscosity changes, blood pressure changes [ 49 , 50 ]. The tissue damage presents as the damage of muscles, ligaments, and tendons due to more or less blood flow in smaller veins [ 2 , 12 ].…”

Section: Resultsmentioning

confidence: 99%

Sinusoidal Microchannel with Descending Curves for Varicose Veins Implantation

et al. 2018

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Approximately 26% of adult people, mostly females, are affected by varicose veins in old age. It is a common reason for distress, loss of efficiency, and worsening living conditions. Several traditional treatment techniques (sclerotherapy and foam sclerotherapy of large veins, laser surgeries and radiofrequency ablation, vein ligation and stripping, ambulatory phlebectomy, and endoscopic vein surgery) have failed to handle this disease effectively. Herein, authors have presented an alternative varicose vein implant method—the descending sinusoidal microchannel (DSMC). DSMC was simulated by Fuzzy logic MATLAB (The MathWorks, Natick, MA, USA) and ANSYS (ANSYS 18.2, perpetual license purchased by Ibadat Education Trust, The University of Lahore, Pakistan) with real and actual conditions. After simulations of DSMC, fabrication and testing were performed. The silver DSMC was manufactured by utilizing a micromachining procedure. The length, width, and depth of the silver substrate were 51 mm, 25 mm, and 1.1 mm, respectively. The measurements of the DSMC channel in the silver wafer substrate were 0.9 mm in width and 0.9 mm in depth. The three descending curves of the DSMC were 7 mm, 6 mm, and 5 mm in height. For pressure, actual conditions were carefully taken as 1.0 kPa to 1.5 kPa for varicose veins. For velocity, actual conditions were carefully taken as 0.02 m/s to 0.07 m/s for these veins. These are real and standard values used in simulations and experiments. At Reynolds number 323, the flow rate and velocity were determined as 1001.0 (0.1 nL/s), 11.4 cm/s and 1015.3 (0.1 nL/s), 12.19 cm/s by MATLAB (The MathWorks, Natick, MA, USA) and ANSYS simulations, respectively. The flow rate and velocity were determined to be 995.3 (0.1 nL/s) and 12.2 cm/s, respectively, at the same Reynolds number (323) in the experiment. Moreover, the Dean number was also calculated to observe Dean vortices. All simulated and experimental results were in close agreement. Consequently, DSMC can be implanted in varicose veins as a new treatment to preserve excellent blood flow in human legs from the original place to avoid tissue damage and other problems.

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“…5F-H), WBRV-L and WBRV-H were mainly determined by EAI and ERI because both of them were thought to be more obviously correlated with the severity of hypertension when there is no obvious change in the aforementioned parameters. 25 Results showed that the enhanced EAI and ERI in I/R groups were alleviated by Edaravone or 004 administration ( Fig. 5I and J).…”

Section: Alleviated Abnormal Hemorheological Indices Changes Causmentioning

confidence: 86%