Erythrocyte Sedimentation Rate and C-Reactive Protein for the Prediction of Severity of Acute Pancreatitis

Abstract

Erythrocyte sedimentation rate can predict severe AP with a slightly inferior performance to CRP. Combined ESR and CRP at 24 hours can predict severe AP accurately.

Early prediction of organ failure under the revised Atlanta classification

“…Massive vascular leakage is one of the main pathophysiological events that occurs before OF (22). C-reactive protein is a well-known marker for predicting severity, complication, and mortality of AP (10,23). Moreover, its testing is inexpensive and easily available, and it has a relatively high sensitivity and specificity within 48 h of symptom onset (10).…”

Does presence of common bile duct stones in patients with acute biliary pancreatitis affect the severity of illness or laboratory findings?

“…However, CRP and WBC counts were higher at 72 hours in the patients who progressed to severe pancreatitis than in the mild pancreatitis patients. CRP was reported to be a practical predictor of severe pancreatitis in some studies and not in others (13,(25)(26)(27)(28)(29). CRP and WBC count are nonspecific markers of infection, and were higher in patients who progressed to severe pancreatitis.…”

Evaluation of serum L-FABP levels in patients with acute pancreatitis

“…Most authors have put forward that CRP is a valuable marker in the early assessment of the severity of acute pancreatitis. [14] Other mutiple serum markers have been studied so as to predict the severity of pancreatitis including urinary trypsinogen activation peptide, procalcitonin, polymorphonuclear elastase, pancreatic-associated protein, amylase and lipase, serum glucose, serum creatinine and calcium, procarboxypeptidase-B, carboxypeptidase B activation peptide, serum trypsinogen-2, phospholipase A-2, serum amyloid protein-A, substance P, antithrombin III, platelet activating factor, interleukins 1, 6, and 8, tumor necrosis factor-alpha or soluble tumor necrosis factor receptor, and various genetic polymorphisms. [15,16] L-FABP is predominantly found in the liver and thought to be involved in the regulation of lipid transport and metabolism.…”