Erythrocyte Sedimentation Rate and C-Reactive Protein: How Best to Use Them in Clinical Practice

Litao, Melissa Kaori Silva; Kamat, Deepak

doi:10.3928/00904481-20140924-10

Cited by 99 publications

(84 citation statements)

References 24 publications

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“…This demonstrated that a CRP concentration of ≥30.5 mg/L presented a good predictive value for identifying bacteraemia in febrile infants aged <28 days. On the other hand, we all know that CRP is an acute‐phase reactant produced by the liver and it is synthesised within four to six hours after the onset of inflammation or injury, doubling every eight hours and peaking at 36–50 hours . However, in the present study, there were 18 (54.5%) neonates with bacteraemia, who arrived at the paediatric emergency department of our hospital within 24 hours of developing a fever.…”

Section: Discussioncontrasting

confidence: 57%

C‐reactive protein concentrations can help to determine which febrile infants under three months should receive blood cultures during influenza seasons

Luo

Zhu

et al. 2017

Acta Paediatrica

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Section: Discussioncontrasting

confidence: 57%

C‐reactive protein concentrations can help to determine which febrile infants under three months should receive blood cultures during influenza seasons

Luo

Zhu

et al. 2017

Acta Paediatrica

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“…ESR and CRP are routine tests prescribed for the evaluation of patients in case of infection diseases. These tests indicate the systemic inflammations in human bodies; however, it is suggested that these two testes be analyzed together for more sensitivity and specificity (21). During the inflammatory process, platelet count increases as part of the acute phase reaction (1).…”

Section: Discussionmentioning

confidence: 99%

Platelet Indices as Useful Indicators of Urinary Tract Infection

Akya

Rostami-Far

Lorestani

et al. 2019

IJPHO

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Background: The changes of platelet parameters can be a useful index for rapid diagnosis of urinary tract infection (UTI), since platelet changes are routinely determined through complete blood count (CBC) test. The correlation between platelet indices, included number (PLTs), mean platelet volume (MPV) and platelet distribution width (PDW), which are the indicators of production and function of platelets, with UTI was evaluated in this study. Materials and Methods: In this descriptive-analytical study, 97 patients with UTI (patient group) and 117 healthy people (control group). The average age for the patient and the control group was 10.84±6.68 and 11.34±7.1 years old, respectively. This study was done during 2016-2018 in Imam Reza Hospital, Kermanshah, west of Iran. The PLT, MPV, PDW, and other inflammatory indices, including white blood cell, neutrophils, lymphocytes, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were evaluated. The diagnosis of bacteria was done using routine microbiological and biochemical methods. The platelet indices were statistically compared between the patients and the control groups (T test and Chi square test). Results: The most common isolated gram negative and gram positive bacteria were E. coli, Citrobacter, and Staphylococcus aureus, respectively. In the patient group, PLT number was significantly higher than that in the control group (p=0.0007), while difference of other indices such as MPV, PDW, neutrophils, lymphocytes, CRP, and ESR were not statistically significant between the two groups. In case of UTI with gram positive bacteria, PLT number (p=0.05) was lower but MPV (p=0.02) and PDW (p=0.045) was higher compared to the UTI with gram negative bacteria. Conclusion: The results of this study showed that the platelet number could be a useful diagnostic index for urinary tract infection. However, more studies need to be done with higher number of patients to evaluate the more details of platelet changes during UTIs.

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“…CRP levels tend to increase rapidly after the onset of inflammation and drop quickly with the administration of antibiotics (17). The ESR changes more slowly than the CRP level during antibiotic therapy (17) (18), which may explain why ESR was more useful for predicting surgical intervention than CRP in this study.…”

Section: Discussionmentioning

confidence: 76%

The prediction of surgical intervention in patients with tubo-ovarian abscess

Hwang

Kim

2020

Preprint

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Background: The prediction of antibiotic treatment failure is helpful to identify patients with a high likelihood of needing surgical treatment early in patients diagnosed with tubo-ovarian abscess (TOA). The aim of this study was to compare the clinical characteristics of patients with TOA) who responded to medical treatment and those who underwent surgical intervention due to medical treatment failure. Material and Methods: Electronic medical records were evaluated retrospectively to identify patients who were diagnosed with TOA and hospitalized in our obstetrics and gynecology department between March 2014 and June 2019. Demographic, clinical, and laboratory data including white blood cell (WBC) count, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were compared between the medical treatment group and the surgical intervention group. Logistic regression was used to determine the independent predictors of treatment failure. Results: Patient age, TOA diameter, WBC count, CRP, and ESR were significantly different between the groups. On multiple regression analysis, significant correlations were identified between age ( p = 0.001), ESR ( p = 0.045), and failure of medical treatment. TOA diameter ( p = 0.065) showed a borderline association with surgical intervention. The risk group was defined as the combination of factors producing a risk score > 2. The area under the curve (AUC) for the risk group (age >34.3 years, ESR > 45 mm/h, and TOA size > 5.9 cm) was 0.844. The sensitivity, specificity, accuracy, PPV, and NPV were 93.8%, 75%, 83.3%, 75%, and 93.8%, respectively. Conclusions: The risk of needing surgical intervention in TOA patients can be predicted using ESR in addition to age and TOA size as risk factors.

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Erythrocyte Sedimentation Rate and C-Reactive Protein: How Best to Use Them in Clinical Practice

Cited by 99 publications

References 24 publications

C‐reactive protein concentrations can help to determine which febrile infants under three months should receive blood cultures during influenza seasons

C‐reactive protein concentrations can help to determine which febrile infants under three months should receive blood cultures during influenza seasons

Platelet Indices as Useful Indicators of Urinary Tract Infection

The prediction of surgical intervention in patients with tubo-ovarian abscess

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