Erythrocyte shape transformation in physiological regulation of blood viscosity

Abstract

The study was carried out to evaluate deformable and aggregative erythrocyte properties in humans under normal and pathological states and in rats exposed to various stressors. A strong correlation between the erythrocyte rheological determinants, i.e. deformability index and aggregation rate, was found under pathological and stress-induced states. The physiological significance of this phenomenon is to maintain the native structure of blood flow.

Rheological Properties of Erythrocytes and Lipid Profiles of Blood Plasma

“…Experiments were undertaken with the understanding and verbal consent of each subject according to the conditions set forth by a Human Subjects and Ethics Review Board. The reversible tendency to form an aggregates (REA) was determined by Tukhvatulin et al (1986) in our modification (Katiukhin, 2013) from analyzing the light transmission data through the whole heparinized blood samples at hematocrit 40% in a glass micro-chamber of 25 mcm height and of 16 mm diameter. The full erythrocyte disaggregation shear stress is achieved by voltage increase on piezo-crystal connected with the surface of the micro-chamber.…”