Erythrocyte survival following extracorporeal circulation

Tabak, Carol; Eugene, John; Stemmer, Edward A.

doi:10.1016/s0022-5223(19)37656-1

Cited by 15 publications

(4 citation statements)

References 8 publications

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“…Hemolysis during cardiopulmonary bypass is known to be mainly associated with roller or centrifugal pumps and suctioning into the cardiotomy reservoir. Red cell injury has been shown to be a function of perfusion time rather than oxygenator employed (8,9). However, shear stresses induced by flow through the oxygenator will impart some damage to red cells (10).…”

Section: Discussionmentioning

confidence: 99%

Impact of Hollow-Fiber Membrane Surface Area on Oxygenator Performance: Dideco D903 Avant Versus a Prototype with Larger Surface Area

Mueller

Tevaearai

Jochheim

et al. 2000

J Extra Corpor Technol

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This study compares the gas transfer capacity, the blood trauma, and the blood path resistance of the hollow-fiber membrane oxygenator Dideco D 903 with a surface area of 1.7 m2 (oxygenator 1.7) versus a prototype built on the same principles but with a surface area of 2 m2 (oxygenator 2). Six calves (mean body weight: 68.2 ± 3.2 kg) were connected to cardiopulmonary bypass (CPB) by jugular venous and carotid arterial cannulation, with a mean flow rate of 4l/min for 6 h. They were randomly assigned to oxygenator 1.7 (N = 3) or 2 (N = 3). After 7 days, the animals were sacrificed. A standard battery of blood samples was taken before the bypass, throughout the bypass, and 24 h, 48 h, and 7 days after the bypass. The oxygenator 2 group showed significantly better total oxygen and carbon dioxide transfer values throughout the perfusion (p < .001 for both comparison). Hemolytic parameters (lactate dehydrogenase and free plasma hemoglobin) exhibited a slight but significant increase after 5 h of bypass in the oxygenator 1.7 group. The pressure drop through the oxygenator was low in both groups (range, 43–74 mmHg). With this type of hollow-fiber membrane oxygenator, an increased surface of gas exchange from 1.7m2 to 2 m2 improves gas transfer, with a limited impact on blood trauma and no increase of blood path resistance.

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Section: Discussionmentioning

confidence: 99%

Impact of Hollow-Fiber Membrane Surface Area on Oxygenator Performance: Dideco D903 Avant Versus a Prototype with Larger Surface Area

Mueller

Tevaearai

Jochheim

et al. 2000

J Extra Corpor Technol

View full text Add to dashboard Cite

show abstract

“…Studies by Hessel, 13 and others 15 • 17 • 18 observed no differences in the degree of hemolysis, as indicated by plasma free hemoglobin levels, between membrane and bubble oxygenators. A recent study by Tabak et a!., 12 using sodium chromate tagged erythrocytes, reported no differences between membrane and bubble oxygenators as a cause of red cell injury. Although Sade 9 reported statistically higher plasma hemoglobin in the bubble oxygenator group in their study, it was only at three of the six time intervals sampled.…”

mentioning

confidence: 94%

“…For years membrane proponents have told us that membrane oxygenators reduce destruction and dysfunction of platelets, reduce hemolysis, and reduce post-operative bleeding when compared to bubble oxygenators. Recent studies by Sade, 9 Edmunds, 10 Trumbell, 11 and Tabak, 12 do not substantiate or refute the significant differences claimed by membrane proponents.…”

mentioning

confidence: 96%

“…Heimbecker 11 states "Because of greatly reduced blood usage, the total cost of a procedure with membrane oxygenation is much less." Morris 12 in his comparisons found the average savings (total hospital cost) of $450 with the membrane system, justifies the additional cost. And finally, Peters 10 concluded ''The decrease in total blood products used per patient in the membrane group far covers the patient cost increase over bubble oxygenator.…”

mentioning

confidence: 98%

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